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Human Monoclonal LCN2 Primary Antibody for ELISA, WB - ABIN1045904
Devarajan: Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of kidney disease. in Scandinavian journal of clinical and laboratory investigation. Supplementum 2008
Show all 18 Pubmed References
Human Monoclonal LCN2 Primary Antibody for ELISA, WB - ABIN1045905
Makris, Markou, Evodia, Dimopoulou, Drakopoulos, Ntetsika, Rizos, Baltopoulos, Haliassos: Urinary neutrophil gelatinase-associated lipocalin (NGAL) as an early marker of acute kidney injury in critically ill multiple trauma patients. in Clinical chemistry and laboratory medicine : CCLM / FESCC 2009
Show all 18 Pubmed References
Rat (Rattus) Polyclonal LCN2 Primary Antibody for IHC (p), WB - ABIN966671
Begley, Robb, Rockman, Visvader, Bockamp, Chan, Green: Structure of the gene encoding the murine SCL protein. in Gene 1994
Show all 6 Pubmed References
Human Polyclonal LCN2 Primary Antibody for IHC, IHC (p) - ABIN4331126
Rathore, Berard, Redensek, Chierzi, Lopez-Vales, Santos, Akira, David: Lipocalin 2 plays an immunomodulatory role and has detrimental effects after spinal cord injury. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Show all 3 Pubmed References
Human Polyclonal LCN2 Primary Antibody for IF (p), IHC (p) - ABIN685627
Xing, Wang, Cheng, Montaner, Mandeville, Leung, van Leyen, Lok, Wang, Lo: Neuronal production of lipocalin-2 as a help-me signal for glial activation. in Stroke; a journal of cerebral circulation 2014
Show all 2 Pubmed References
Human Polyclonal LCN2 Primary Antibody for IHC (p), IHC - ABIN250360
Yu, Wu, Ping, Huang, Shen: NGAL can alternately mediate sunitinib resistance in renal cell carcinoma. in The Journal of urology 2014
Show all 2 Pubmed References
Human Polyclonal LCN2 Primary Antibody for IF (p) - ABIN908242
Xu, Zhang, Cheng, Liu, Zou, Zhan, Xiao, Xia: Transcription factor 7-like 1 dysregulates keratinocyte differentiation through upregulating lipocalin 2. in Cell death discovery 2016
Rat (Rattus) Monoclonal LCN2 Primary Antibody for ELISA, ICC - ABIN451573
Sultan, Ahmad, Rave-Fränk, Malik, Hess, Christiansen, Cameron: Induction of Lipocalin2 in a Rat Model of Lung Irradiation. in International journal of molecular sciences 2016
Study results suggest that stratum corneum neutrophil gelatinase-associated lipocalin may be useful as an objective biomarker of changes in acne vulgaris symptoms.
Increased serum levels of NGAL were associated with loss of graft function in kidney transplant recipients.
In Colombian systemic lupus erythematosus patients, urinary NGAL and MCP-1 (show CCL2 Antibodies) in addition to anti-C1q antibodies were useful biomarkers for the identification of renal involvement and discrimination of active lupus nephritis.
a mutant form (K3Cys) of endogenous lipocalin 2 (LCN2) is filtered by the kidney but can bypass sites of megalin (show LRP2 Antibodies)-dependent recapture, resulting in urinary excretion
predictive value of plasma neutrophil gelatinase-associated lipocalin (pNGAL) in patients with severe sepsis
Results showed the expression levels of NGAL and NGALR (show SLC22A17 Antibodies) significantly downregulated in clear cell renal cell carcinoma (show MOK Antibodies) samples.
The main finding of the present study was that serum NGAL levels paralleled increasing clinical activity of ulcerative colitis evaluated by Mayo score, and it also discriminated different stages of endoscopic severity of this disease. By contrast, only insignificant association of NGAL with endoscopic activity of Crohn's disease was found with no relationships with clinical activity scores.
Upon screening of blood mediators in palmoplantar pustular psoriasis patients, LCN2 emerged as being significantly upregulated compared to healthy participants.
Neutrophil gelatinase-associated lipocalin concentrations in the urine and serum on the second day of intensive care unit admission could be used to predict the development of acute kidney injury in the following three to seven days in the intensive care unit; however, the cystatin C (show CST3 Antibodies) concentration did not have predictive value
In non-chronic kidney disease group, plasma NGAL was not associated with any baseline variables including iron indices
High LCN2 expression is associated with stress-induced mitochondrial dysfunction and heart failure.
tibias of botulin A toxin-treated and tail-suspended mice, which featured unloading and decreased bone mass, showed higher expression of IL-1beta, Lcn2 and Nos2, suggesting their pathophysiologic involvement in endothelial cell-osteoblast crosstalk.
Findings of the study revealed that Lcn2 prevents the development of spontaneous colitis in IL-10 (show IL10 Antibodies) deficient mice by enhancing phagocytic bacterial clearance in macrophages. The results clearly demonstrated a crucial role for Lcn2/NGAL in the development of intestinal inflammation by its regulation of mucosal innate immune responses toward enteric commensal bacteria.
Results suggest that hippocampal LCN2 upregulation might be a potential pathogenic mechanism leading to further disruption of the hippocampus through neurotoxicity and neuroinflammation in vascular dementia (VaD (show KCTD1 Antibodies)). Astrocytes seem to be the major source of LCN2 in the hippocampus of rodent models and patients of VaD (show KCTD1 Antibodies). Control of hippocampal astrocytic LCN2 expression or activity may be important for neuroprotection in VaD (show KCTD1 Antibodies).
Direct effects of LCN2 on cardiomyocyte size and number and the consistent associations in experimental and human analyses reveal a central role for LCN2 in the ontogeny of cardiac hypertrophy and heart failure
the present study used an animal model to identify NGAL as a potential novel biomarker for mechanical-induced lung injury.
Lipocalin-2 from both myeloid cells and the epithelium combats Klebsiella pneumoniae lung infection in mice.
IL-1beta (show IL1B Antibodies) has a direct effect on NGAL production by tubular epithelial cells.
Knockout of Lcn2 attenuated tumor-associated lymphangiogenesis and breast tumor metastasis
Overexpression of exogenous kidney-specific Ngal reduced cystic progression and prolonged the lifespan in polycystic kidney disease mice, and was associated with reductions in interstitial fibrosis and proliferation, and augmented apoptosis.
we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9 (show MMP9 Antibodies), TIMP1 (show TIMP1 Antibodies), and NGAL (also MMP2 (show MMP2 Antibodies) in 220 kDa complex) without proteolytic activity.
porcine p25alpha (show Tppp Antibodies) is heavily modified with a variety of modifications: phosphorylation, di- and trimethylation, citrullination and a HexNAc group.
mouse homolog plays a role in IL3 withdrawal-induced apoptosis
, lipocalin 2 (oncogene 24p3)
, 25 kDa alpha-2-microglobulin-related subunit of MMP-9
, migration-stimulating factor inhibitor
, neutrophil gelatinase-associated lipocalin
, oncogene 24p3
, siderocalin LCN2
, SV-40-induced 24P3 protein
, secreted inducible protein 24
, alpha-2-microglobulin-related protein
, alpha-2U globulin-related protein