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Human Monoclonal LCN2 Primary Antibody for ELISA, WB - ABIN1045905
Devarajan: Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of kidney disease. in Scandinavian journal of clinical and laboratory investigation. Supplementum 2008
Show all 18 Pubmed References
Human Monoclonal LCN2 Primary Antibody for ELISA, WB - ABIN1045904
Makris, Markou, Evodia, Dimopoulou, Drakopoulos, Ntetsika, Rizos, Baltopoulos, Haliassos: Urinary neutrophil gelatinase-associated lipocalin (NGAL) as an early marker of acute kidney injury in critically ill multiple trauma patients. in Clinical chemistry and laboratory medicine : CCLM / FESCC 2009
Show all 18 Pubmed References
Rat (Rattus) Polyclonal LCN2 Primary Antibody for IHC (p), WB - ABIN966671
Begley, Robb, Rockman, Visvader, Bockamp, Chan, Green: Structure of the gene encoding the murine SCL protein. in Gene 1994
Show all 6 Pubmed References
Human Polyclonal LCN2 Primary Antibody for IHC, IHC (p) - ABIN4331126
Rathore, Berard, Redensek, Chierzi, Lopez-Vales, Santos, Akira, David: Lipocalin 2 plays an immunomodulatory role and has detrimental effects after spinal cord injury. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Show all 3 Pubmed References
Human Polyclonal LCN2 Primary Antibody for IF (p), IHC (p) - ABIN685627
Xing, Wang, Cheng, Montaner, Mandeville, Leung, van Leyen, Lok, Wang, Lo: Neuronal production of lipocalin-2 as a help-me signal for glial activation. in Stroke; a journal of cerebral circulation 2014
Show all 2 Pubmed References
Human Polyclonal LCN2 Primary Antibody for IHC (p), IHC - ABIN250360
Yu, Wu, Ping, Huang, Shen: NGAL can alternately mediate sunitinib resistance in renal cell carcinoma. in The Journal of urology 2014
Show all 2 Pubmed References
Human Polyclonal LCN2 Primary Antibody for IF (p) - ABIN908242
Xu, Zhang, Cheng, Liu, Zou, Zhan, Xiao, Xia: Transcription factor 7-like 1 dysregulates keratinocyte differentiation through upregulating lipocalin 2. in Cell death discovery 2016
Mouse (Murine) Polyclonal LCN2 Primary Antibody for ELISA, WB - ABIN408671
Venkatesha, Hanai, Seth, Karumanchi, Sukhatme: Lipocalin 2 antagonizes the proangiogenic action of ras in transformed cells. in Molecular cancer research : MCR 2006
Rat (Rattus) Monoclonal LCN2 Primary Antibody for ELISA, ICC - ABIN451573
Sultan, Ahmad, Rave-Fränk, Malik, Hess, Christiansen, Cameron: Induction of Lipocalin2 in a Rat Model of Lung Irradiation. in International journal of molecular sciences 2016
Urinary NGAL is a good predictor of mortality in established pediatric acute kidney injury (AKI) of heterogeneous etiology and outperforms calprotectin (show S100A8 Antibodies) and KIM-1 (show HAVCR1 Antibodies). Urinary calprotectin (show S100A8 Antibodies) and KIM-1 (show HAVCR1 Antibodies) predict renal replacement therapy requirement in pediatric AKI.
asma (show ACTA1 Antibodies) NGAL can be more useful than serum procalcitonin, C-reactive protein (show CRP Antibodies) , and white blood cell levels for identifying acute pyelonephritis in children with febrile urinary tract infections
These findings indicate that circulating levels of lipocalin-2 (LCN-2)in patients after acute pancreatitis may play a role in chronic low grade inflammation associated with abdominal adiposity.
Neutrophil gelatinase-associated lipocalin may play a dual role during tumorigenetic and developmental processes of endometrial carcinoma.
This study shows the find NGAL levels are significantly higher in regions throughout the brain which are commonly affected by AD pathology.
Through transcriptome profiling and combined gain- and loss-of-function studies, the authors identified LCN2 as a major downstream effector of TCF7L1 (show TCF3 Antibodies) that drives tumor growth.
Lipocalin 2 could facilitate proliferation of castration-resistant prostate cancer cells by activating androgen receptor (show AR Antibodies) transcriptional activity.
Urinary NGAL measured at ICU admission was significantly associated with long-term renal outcomes after hospital discharge in MAKE-free ICU survivors. Urinary NGAL measurements at ICU might be useful to identify a high risk population of kidney disease progression after intensive care.
Recent evidence supports the existence of transferrin (show Tf Antibodies)-independent iron transport mechanisms in the tumor microenvironment, which points to local iron transport proteins such as lipocalin-2 and/or low molecular weight iron-trafficking substances such as siderophores. [review]
Urinary NGAL might play role in the pathway of renal tubular damage in patients with autosomal-dominant polycystic kidney disease
Lipocalin-2 from both myeloid cells and the epithelium combats Klebsiella pneumoniae lung infection in mice.
IL-1beta (show IL1B Antibodies) has a direct effect on NGAL production by tubular epithelial cells.
Knockout of Lcn2 attenuated tumor-associated lymphangiogenesis and breast tumor metastasis
Overexpression of exogenous kidney-specific Ngal reduced cystic progression and prolonged the lifespan in polycystic kidney disease mice, and was associated with reductions in interstitial fibrosis and proliferation, and augmented apoptosis.
Either Lcn2 deficiency or anti-Lcn2 antibody blockade limits abdominal aortic aneurysm expansion in mice by decreasing neutrophil infiltration in the aorta.
Results suggest that blood brain barrier leakage occurs in white matter after subarachnoid hemorrhage (SAH (show ACSM3 Antibodies)) and that LCN2 contributes to SAH (show ACSM3 Antibodies)-induced blood brain barrier disruption.
LCN2 overexpression in bones modifies the bone marrow microenvironment via modulation of the expression of key secreted factors and cytokines, which in turn regulate the hematopoietic stem cell niche behavior enhancing both HSC (show FUT1 Antibodies) homing in young mice and erythrocytes production in older mice.
LCN2 modulated the secretion of proinflammatory cytokines in PSC of the PDAC tumor microenvironment, whereas downregulation of LCN2-specific receptor SLC22A17 (show SLC22A17 Antibodies) blocked these effects. Our results reveal how LCN2 acts in the tumor microenvironment links obesity, inflammation, and PDAC development.
results identify lipocalin 2 as a bone-derived hormone with metabolic regulatory effects, which suppresses appetite in a MC4R (show MC4R Antibodies)-dependent manner, and show that the control of appetite is an endocrine function of bone
Lcn2 can suppress the beneficial cardiac autophagic response to ischemia and that this contributes to enhanced ischemia-induced cell death and cardiac dysfunction.
we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9 (show MMP9 Antibodies), TIMP1 (show TIMP1 Antibodies), and NGAL (also MMP2 (show MMP2 Antibodies) in 220 kDa complex) without proteolytic activity.
porcine p25alpha (show Tppp Antibodies) is heavily modified with a variety of modifications: phosphorylation, di- and trimethylation, citrullination and a HexNAc group.
mouse homolog plays a role in IL3 withdrawal-induced apoptosis
, lipocalin 2 (oncogene 24p3)
, 25 kDa alpha-2-microglobulin-related subunit of MMP-9
, migration-stimulating factor inhibitor
, neutrophil gelatinase-associated lipocalin
, oncogene 24p3
, siderocalin LCN2
, SV-40-induced 24P3 protein
, secreted inducible protein 24
, alpha-2-microglobulin-related protein
, alpha-2U globulin-related protein