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anti-Human EP400 Antibodies:
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Human Polyclonal EP400 Primary Antibody for IP, PLA - ABIN152345
Young, Schlisio, Minamishima, Zhang, Li, Grisanzio, Signoretti, Kaelin: VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400. in Nature cell biology 2008
Show all 6 Pubmed References
Human Monoclonal EP400 Primary Antibody for ELISA, WB - ABIN528254
Iwai, Takegami, Shiozaki, Miyazaki: Hepatitis C virus NS3 protein can activate the Notch-signaling pathway through binding to a transcription factor, SRCAP. in PLoS ONE 2011
Human Polyclonal EP400 Primary Antibody for ICC, IF - ABIN4342732
Obri, Ouararhni, Papin, Diebold, Padmanabhan, Marek, Stoll, Roy, Reilly, Mak, Dimitrov, Romier, Hamiche: ANP32E is a histone chaperone that removes H2A.Z from chromatin. in Nature 2014
Taken together, the findings suggest that a protein-protein interaction between ATM and p400 ATPase occurs independently of DNA damage and contributes to efficient DNA damage response and repair.
All together these results show that p400 acts as a brake to prevent alternative End Joining-dependent genetic instability and underline its potential value as a clinical marker.
EP400 deposits H3.3 into chromatin alongside H2AZ and contributes to gene regulation after Pol II pre-initiation complex assembly.
Data indicate that three genes, namely Chemokine (C-X-C motif) receptor 2 (CXCR2), C-C chemokine receptor type 2 (CCR2) and E1A-Binding Protein P400 (EP400), were able to identify HCC individually with accuracies of 82.4%, 78.4% and 65%, respectively.
Our data suggest that the highly proliferative, decreased-p400 subgroup of renal cell carcinomas represents tumors that are characterized by a loss of the tumor-suppressive mechanism of senescence.
age-dependent p400 downregulation and loss of H2A.Z localisation may contribute to the onset of replicative senescence through a sustained high rate of p21 transcription
The p400 ATPase is required for DNA repair by homologous recombination.
incorporation of the histone variant H2A.Z at the promoter regions of PPARgamma target genes by p400/Brd8 is essential to allow fat cell differentiation
p400 is a novel DNA damage response protein and p400-mediated alterations in nucleosome and chromatin structure promote both chromatin ubiquitination and the accumulation of brca1 and 53BP1 at sites of DNA damage.
Depletion of p400 indeed increases intracellular reactive oxygen species levels and causes the appearance of DNA damage
Results suggest that p400 represses basal p21 gene expression through dual mechanisms that include direct inhibition of TIP60 and ATP-dependent positioning of H2A.Z at the promoter.
p400 is a component of the p53-p21(WAF1/CIP1/sid1) pathway, regulating the p21 transcription and cell senescence induction program.
p400 is a regulator of the ARF-p53 pathway and a component of the cellular machinery that couples proliferation to cell death
Tip60 and p400 play distinct roles in DNA damage-induced apoptosis and underline the importance of the Tip60 complex and its regulation in the proper control of cell fate.
These findings establish that Myc, via p400, is an essential downstream target of adenovirus E1A.
Myc recruits the Tip60/p400 complex to achieve a coordinated histone acetylation/exchange reaction at activated promoters.
p400/Tip60 ratio is critical for colon cancer cells proliferation and response to therapeutic drugs through the control of stress-response pathways.
Ep400 absence causes peripheral neuropathy in mice, characterized by terminal differentiation defects in myelinating and non-myelinating Schwann cells and immune cell activation.
p400/mDomino plays a key role in cellular proliferation by controlling the expression of cell-cycle-regulatory genes.
p400/mDomino plays a critical role in embryonic hematopoiesis by regulating the expression of developmentally essential genes such as those in the Hox gene cluster.
senescence induced by VHL inactivation is a tumour-suppressive mechanism mediated by Rb and p400 (and HIF independent) that must be overcome to develop VHL-associated neoplasias
These data indicate that Tip60-p400 integrates signals from Nanog and H3K4me3 to regulate gene expression in embryonic stem cells.
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400 (By similarity). Regulates transcriptional activity of ZNF42.
CAG repeat protein 32
, E1A-binding protein p400
, domino homolog
, p400 SWI2/SNF2-related protein
, p400 kDa SWI2/SNF2-related protein
, trinucleotide repeat containing 12
, trinucleotide repeat-containing gene 12 protein
, E1A binding protein p400
, E1a binding protein P400
, e1A-binding protein p400-like