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Human Monoclonal FOXP1 Primary Antibody for IHC (f), IHC (fro) - ABIN2689508
Brown, Ashe, Leich, Burek, Barrans, Fenton, Jack, Pulford, Rosenwald, Banham: Potentially oncogenic B-cell activation-induced smaller isoforms of FOXP1 are highly expressed in the activated B cell-like subtype of DLBCL. in Blood 2008
Show all 10 Pubmed References
Human Monoclonal FOXP1 Primary Antibody for CyTOF, FACS - ABIN256072
Fox, Brown, Han, Ashe, Leek, Harris, Banham: Expression of the forkhead transcription factor FOXP1 is associated with estrogen receptor alpha and improved survival in primary human breast carcinomas. in Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Show all 7 Pubmed References
Cow (Bovine) Polyclonal FOXP1 Primary Antibody for IHC, WB - ABIN2779725
Shi, Zhang, Chen, Sulaiman, Feinberg, Ballantyne, Jain, Simon: Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1. in The Journal of clinical investigation 2004
Show all 4 Pubmed References
Human Monoclonal FOXP1 Primary Antibody for FACS, IHC - ABIN1098120
Chen, Xiao, Zhang, Li, Liu, Zhao, Ma, Luo, Qiu, Huang, Korteweg, Gu: Transcription factors E2A, FOXO1 and FOXP1 regulate recombination activating gene expression in cancer cells. in PLoS ONE 2011
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Mouse (Murine) Monoclonal FOXP1 Primary Antibody for ChIP, EMSA - ABIN2668950
Wang, Lin, Li, Tucker: Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors. in The Journal of biological chemistry 2003
Show all 2 Pubmed References
Human Monoclonal FOXP1 Primary Antibody for ELISA, WB - ABIN565325
Brown, Kagaya, Banham: Characterization of human FOXP1 isoform 2, using monoclonal antibody 4E3-G11, and intron retention as a tissue-specific mechanism generating a novel FOXP1 isoform. in Histopathology 2008
Human Monoclonal FOXP1 Primary Antibody for IHC (fro), IHC (p) - ABIN2473693
Pink, Seidel, Ziegelitz, Correns, Knappe: [TSH base values in thyroid gland functional diagnosis with an improved radioimmunoassay technic]. in Radiobiologia, radiotherapia 1980
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Prominent foxp1 expression is detected in many regions of the developing central nervous system, especially in midbrain-hindbrain boundary, hindbrain, and spinal cord.
we have identified a novel de novo missense variant in FOXP1 that is identical to the most well-studied etiological variant in FOXP2 (show FOXP2 Antibodies). Functional characterization revealed clear similarities between these equivalent mutations in terms of their impact on protein function.
FOXP1-related intellectual disability syndrome (ID) is a recognisable entity with wide clinical spectrum and frequent systemic involvement; more ID and neuromotor delay, sensorineural hearing loss and feeding difficulties are more common in patients with interstitial 3p deletions versus patients with monogenic FOXP1 defects; Mutations result in impaired transcriptional repression and/or reduced protein stability
Prognostic value of decreased FOXP1 protein expression in various tumors, is reported.
Blimp1 (show PRDM1 Antibodies), Foxp1 and pStat3 are expressed in extranodal diffuse large B-cell lymphomas
Two rare novel FOXP1 variants associated with a phenotype similar to Mental Retardation with Language Impairment and with or without Autistic Features (MIM (show MTSS1 Antibodies) 613670).
High FOXP1 expression is associated with acute lymphoblastic leukemia.
The majority of pathogenic missense and in-frame mutations lie in the DNA-binding domain. The mutations perturb amino acids necessary for binding to the DNA or interfere with the domain swapping that mediates FOXP1 dimerization.
Increased frequency of FOXP2 (show FOXP2 Antibodies) expression significantly correlated with FOXP1-positivity, and FOXP1 co-immunoprecipitated FOXP2 (show FOXP2 Antibodies) from activated B-cell-diffuse large B-cell lymphoma (ABC (show ABCB6 Antibodies)-DLBCL) cells.
EBV-miR (show MLXIP Antibodies)-BART11 plays a crucial role in the promotion of inflammation-induced nasopharyngeal carcinoma (NPC (show NPC1 Antibodies)) and gastric cancer (GC) carcinogenesis by directly targeting and inhibiting FOXP1 tumor-suppressive effects.
results reveal a novel regulatory pathway, underscoring a previously unknown and interconnected key role of PUM1 (show PUM1 Antibodies)/2 and FOXP1 in regulating normal hematopoietic stem/progenitor cell and leukemic cell growth.
Foxp1 has a putative HuR (show ELAVL1 Antibodies) binding sites in the 3' UTR (show UTS2R Antibodies). HuR (show ELAVL1 Antibodies) suppresses Foxp1 translation during early neocortical neurogenesis (E13). In HuR (show ELAVL1 Antibodies) knockout mice, decreased Foxp1 mRNA was paralleled by increased Foxp1 protein at E13. Phosphorylation sites on HuR (show ELAVL1 Antibodies) act in post-transcriptional regulation of Foxp1.
Study identified the roles of Foxo1 as a positive regulator and Foxp1 as a negative regulator of TH9 cell differentiation and antitumor activity.
deletion of Foxp1 in the developing forebrain leads to impairments in neonatal vocalizations as well as neocortical cytoarchitectonic alterations via neuronal positioning and migration
Foxp1 conditional knock-out (Foxp1(cKO)) mice with loss of Foxp1 in the neocortex and hippocampus display autism and intellectual-disability-relevant behaviors
These results indicate that FOXP1 attenuates MSC (show MSC Antibodies) senescence by orchestrating their cell-fate switch while maintaining their replicative capacity in a dose- and age-dependent manner.
Although the mutant huntingtin (show HTT Antibodies) gene is expressed widely, neurons of the striatum and cortex are selectively affected in Huntington's disease (HD). Our results suggest that this selectivity is attributable to the reduced expression of Foxp1, a protein expressed selectively in striatal and cortical neurons that plays a neuroprotective role in these cells.
studies suggest that Foxp1 enforces naive CD8 (show CD8A Antibodies)(+) T cell quiescence by simultaneously repressing key pathways in both cellular metabolism and cell cycle progression
Loss of Foxp1 results in loss of suture and fiber cell alignment, which eventually causes lens opacity (show MIP Antibodies), suggesting that Foxp1 has a key role in establishing cortical lens architecture.
we demonstrated for the first time that Foxp1 and Foxp2 (show FOXP2 Antibodies) are expressed during craniofacial development. Our data suggest that the Foxp (show FOXP2 Antibodies) genes may regulate development of the aboral and posterior regions of the jaw.
Combined loss of all three Foxp1/2/4 family members in the developing anterior foregut endoderm leads to a loss of lung endoderm lineage commitment and subsequent development. Foxp1/2/4 deficient lungs express high levels of transcriptional regulators not normally expressed in developing lung. Foxp1 binds to conserved forkhead DNA binding sites within the Hoxa9 (show HOXA9 Antibodies)-13 cluster, indicating a direct repression mechanism.
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.
forkhead box P1
, forkhead box protein P1-B
, forkhead box protein P1-like
, forkhead box protein P1
, fork head-related protein like B
, glutamine-rich factor 1
, forkhead-related transcription factor 1