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anti-Human FOXP1 Antibodies:
anti-Mouse (Murine) FOXP1 Antibodies:
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Human Monoclonal FOXP1 Primary Antibody for IHC (f), IHC (fro) - ABIN2689508
Brown, Ashe, Leich, Burek, Barrans, Fenton, Jack, Pulford, Rosenwald, Banham: Potentially oncogenic B-cell activation-induced smaller isoforms of FOXP1 are highly expressed in the activated B cell-like subtype of DLBCL. in Blood 2008
Show all 10 Pubmed References
Human Monoclonal FOXP1 Primary Antibody for CyTOF, FACS - ABIN256072
Fox, Brown, Han, Ashe, Leek, Harris, Banham: Expression of the forkhead transcription factor FOXP1 is associated with estrogen receptor alpha and improved survival in primary human breast carcinomas. in Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Show all 7 Pubmed References
Cow (Bovine) Polyclonal FOXP1 Primary Antibody for IHC, WB - ABIN2779725
Shi, Zhang, Chen, Sulaiman, Feinberg, Ballantyne, Jain, Simon: Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1. in The Journal of clinical investigation 2004
Show all 4 Pubmed References
Human Monoclonal FOXP1 Primary Antibody for FACS, IHC - ABIN1098120
Chen, Xiao, Zhang, Li, Liu, Zhao, Ma, Luo, Qiu, Huang, Korteweg, Gu: Transcription factors E2A, FOXO1 and FOXP1 regulate recombination activating gene expression in cancer cells. in PLoS ONE 2011
Show all 2 Pubmed References
Mouse (Murine) Monoclonal FOXP1 Primary Antibody for ChIP, EMSA - ABIN2668950
Wang, Lin, Li, Tucker: Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors. in The Journal of biological chemistry 2003
Show all 2 Pubmed References
Human Monoclonal FOXP1 Primary Antibody for ELISA, WB - ABIN565325
Brown, Kagaya, Banham: Characterization of human FOXP1 isoform 2, using monoclonal antibody 4E3-G11, and intron retention as a tissue-specific mechanism generating a novel FOXP1 isoform. in Histopathology 2008
Human Monoclonal FOXP1 Primary Antibody for FACS, IHC (p) - ABIN1689104
Rouhigharabaei, Finalet Ferreiro, Tousseyn, van der Krogt, Put, Haralambieva, Graux, Maes, Vicente, Vandenberghe, Cools, Wlodarska: Non-IG aberrations of FOXP1 in B-cell malignancies lead to an aberrant expression of N-truncated isoforms of FOXP1. in PLoS ONE 2014
Human Monoclonal FOXP1 Primary Antibody for IHC (fro), IHC (p) - ABIN2473693
Pink, Seidel, Ziegelitz, Correns, Knappe: [TSH base values in thyroid gland functional diagnosis with an improved radioimmunoassay technic]. in Radiobiologia, radiotherapia 1980
Show all 2 Pubmed References
Prominent foxp1 expression is detected in many regions of the developing central nervous system, especially in midbrain-hindbrain boundary, hindbrain, and spinal cord.
The majority of pathogenic missense and in-frame mutations lie in the DNA-binding domain. The mutations perturb amino acids necessary for binding to the DNA or interfere with the domain swapping that mediates FOXP1 dimerization.
Increased frequency of FOXP2 (show FOXP2 Antibodies) expression significantly correlated with FOXP1-positivity, and FOXP1 co-immunoprecipitated FOXP2 (show FOXP2 Antibodies) from activated B-cell-diffuse large B-cell lymphoma (ABC (show ABCB6 Antibodies)-DLBCL) cells.
EBV-miR (show MLXIP Antibodies)-BART11 plays a crucial role in the promotion of inflammation-induced nasopharyngeal carcinoma (NPC (show NPC1 Antibodies)) and gastric cancer (GC) carcinogenesis by directly targeting and inhibiting FOXP1 tumor-suppressive effects.
results reveal a novel regulatory pathway, underscoring a previously unknown and interconnected key role of PUM1 (show PUM1 Antibodies)/2 and FOXP1 in regulating normal hematopoietic stem/progenitor cell and leukemic cell growth.
Although the mutant huntingtin (show HTT Antibodies) gene is expressed widely, neurons of the striatum and cortex are selectively affected in Huntington's disease (HD). Our results suggest that this selectivity is attributable to the reduced expression of Foxp1, a protein expressed selectively in striatal and cortical neurons that plays a neuroprotective role in these cells.
the activity of multiple alternate FOXP1 promoters to produce multiple protein isoforms is likely to regulate B-cell maturation (show TNFRSF17 Antibodies).
these novel insights into the function of FOXP1 isoforms in controlling the transcriptional program, survival and differentiation of B cells advance our understanding of the role of FOXP1 in lymphomagenesis and further enhance the value of FOXP1 for diagnostics, prognostics, and treatment of DLBCL patients.
Data indicate that forkhead box P1 protein (FOXP1) as a target of microRNA miR (show MLXIP Antibodies)-92a in primary mediastinal large B-cell lymphoma (PMBL).
Results suggest that domain swapping in FoxP1 is at least partially linked to monomer folding stability and follows an unusual three-state folding mechanism, which might proceed via transient structural changes rather than requiring complete protein unfolding as do most domain-swapping proteins
these data identify FOXP1 as an essential transcriptional regulator for primary human CD4 (show CD4 Antibodies)(+) T cells and suggest its potential important role in the development of PTCL.
deletion of Foxp1 in the developing forebrain leads to impairments in neonatal vocalizations as well as neocortical cytoarchitectonic alterations via neuronal positioning and migration
Foxp1 conditional knock-out (Foxp1(cKO)) mice with loss of Foxp1 in the neocortex and hippocampus display autism and intellectual-disability-relevant behaviors
These results indicate that FOXP1 attenuates MSC (show MSC Antibodies) senescence by orchestrating their cell-fate switch while maintaining their replicative capacity in a dose- and age-dependent manner.
studies suggest that Foxp1 enforces naive CD8 (show CD8A Antibodies)(+) T cell quiescence by simultaneously repressing key pathways in both cellular metabolism and cell cycle progression
Loss of Foxp1 results in loss of suture and fiber cell alignment, which eventually causes lens opacity (show MIP Antibodies), suggesting that Foxp1 has a key role in establishing cortical lens architecture.
we demonstrated for the first time that Foxp1 and Foxp2 (show FOXP2 Antibodies) are expressed during craniofacial development. Our data suggest that the Foxp (show FOXP2 Antibodies) genes may regulate development of the aboral and posterior regions of the jaw.
Combined loss of all three Foxp1/2/4 family members in the developing anterior foregut endoderm leads to a loss of lung endoderm lineage commitment and subsequent development. Foxp1/2/4 deficient lungs express high levels of transcriptional regulators not normally expressed in developing lung. Foxp1 binds to conserved forkhead DNA binding sites within the Hoxa9 (show HOXA9 Antibodies)-13 cluster, indicating a direct repression mechanism.
We show that Foxp1 and the androgen receptor (show AR Antibodies) are co-expressed in striatal medium spiny neurons and that brain-specific (show CALY Antibodies) androgen receptor (show AR Antibodies) KO (ArNesCre) mice exhibit reduced Foxp1 expression in the striatum at E17.5 and P7.5 and an increased Foxp2 (show FOXP2 Antibodies) level in the cortex at P7.5. Thus, androgens may contribute to sex-specific differences in Foxp1 and Foxp2 (show FOXP2 Antibodies) expression and ultrasonic vocalizations
This study demonstrated the utility of FoxP1 to label MSNs in vitro and following neural transplantation, and show that FoxP1 is required for DARPP-32 (show PPP1R1B Antibodies) positive MSN (show MSN Antibodies) differentiation in vitro.
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.
forkhead box P1
, forkhead box protein P1-B
, forkhead box protein P1-like
, forkhead box protein P1
, fork head-related protein like B
, glutamine-rich factor 1
, forkhead-related transcription factor 1