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Based on segregation analysis of a patient (case 296491) with an intragenic deletion of the MBD5 gene, we classified deletions of exons 3 to 4 of the 5' untranslated region (UTR (show UTS2R Antibodies)) of this gene as probably benign. The deletion of exon 3 was shared with the father and paternal uncle, both unaffected
A novel frameshift mutation c.254_255delGA (p.Arg85Asnfs*6) in the MBD5 gene was identified in a family with intellectual disability and epilepsy.
Circadian rhythm gene expression altered by haploinsufficiency of MBD5.
Results show that when MBD5 and RAI1 (show DOM3Z Antibodies) are haploinsufficient, they perturb several common pathways that are linked to neuronal and behavioral development.
Reduced MBD5 dosage leads to mRNA and microRNA expression patterns and DNA methylation (show HELLS Antibodies) patterns more characteristic of differentiating than proliferating neural stem cells. This balance change may underlie neurodevelopmental disorders.
We studied and showed that both MBD5 and MBD6 (show MBD6 Antibodies) interact with the mammalian PR-DUB Polycomb (show CBX2 Antibodies) protein complex in a mutually exclusive manner, and that the MBD (show DPEP1 Antibodies) of MBD5 and MBD6 (show MBD6 Antibodies) is both necessary and sufficient to mediate this interaction.
The features associated with a deletion, mutation or duplication of MBD5 and the gene expression changes observed support MBD5 as a dosage-sensitive gene critical for normal development.
study demonstrates that haploinsufficiency of MBD5 causes diverse phenotypes, yields insight into the spectrum of resulting neurodevelopmental and behavioral psychopathology and provides clinical context for interpretation of MBD5 structural variations.
A genomic copy number variant analysis implicates the MBD5 and HNRNPU (show HNRNPU Antibodies) genes in Chinese children with infantile spasms and expands the clinical spectrum of 2q23.1 deletion.
Identified de novo intragenic deletions of MBD5 in three patients.
This study indicates that the Mbd5(+/) (GT) mouse model recapitulates most of the hallmark phenotypes observed in 2q23.1 deletion carriers including abnormal social behavior, cognitive impairment, and motor and craniofacial abnormalities.
MBD5 regulates iron metabolism via methylation-independent genomic targeting of Fth1 (show FTH1 Antibodies).
These results indicate Mbd5 as an essential factor for mouse postnatal growth and maintenance of glucose homeostasis
This gene encodes a member of the methyl-CpG-binding domain (MBD) family. The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain, this protein contains a PWWP domain (Pro-Trp-Trp-Pro motif), which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division, growth and differentiation. Mutations in this gene cause mental retardation autosomal dominant type 1. Haploinsufficiency of this gene is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures. Alternatively spliced transcript variants have been found, but their full-length nature is not determined.
methyl-CpG binding domain protein 5
, methyl-CpG-binding domain protein 5
, methyl-CpG-binding domain protein 5-like
, methyl-CpG-binding protein MBD5