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anti-Human MEIS1 Antibodies:
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Human Polyclonal MEIS1 Primary Antibody for ELISA, WB - ABIN451639
Wong, Iwasaki, Somervaille, So, So, Cleary: Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. in Genes & development 2007
Human Polyclonal MEIS1 Primary Antibody for ELISA, WB - ABIN561793
Xiong, Catoire, Dion, Gaspar, Lafrenière, Girard, Levchenko, Rivière, Fiori, St-Onge, Bachand, Thibodeau, Allen, Earley, Turecki, Montplaisir, Rouleau: MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels. in Human molecular genetics 2009
By investigating the role of MEIS1 in ccRCC cells' survival, proliferation, anchorage-independent growth, cell cycle progress, apoptosis and metastasis, in the present work, we propose that MEIS1 may play an important role in clear cell renal cell carcinoma (show MOK Antibodies) (ccRCC) development.
Conclusions MEIS1 variants were associated with an increased risk of RLS in migraine patients. It is possible that an imbalance in iron homeostasis and the dopaminergic system may represent a link between RLS incidence and migraines.
We speculate that ACTR2 and MEIS1 might respectively play a role in the pathogenesis of the observed deafness and cardiomyopathy...the patient carrying a 2p14p15 deletion including OTX1 had normal kidneys and genitalia, thus confirming that OTX1 haploinsufficiency is not invariably associated with genitourinary defects.
results reveal that MEIS1, through induction of SYTL1 (show SYTL1 Antibodies), promotes leukemogenesis and supports leukemic cell homing and engraftment, facilitating interactions between leukemic cells and bone marrow stroma.
Meis1 regulates expression and activation of Syk (show SYK Antibodies) in Hoxa9 (show HOXA9 Antibodies)-driven leukemia.
Here we present the result of a 4-stage genome-wide association study composed of 5,953 adolescent idiopathic scoliosis patients and 8,137 controls. Overall, we identified three novel susceptible loci including rs7593846 at 2p14 near MEIS1 , rs7633294 at 3p14.1 near MAGI1 (show MAGI1 Antibodies) and rs9810566 at 3q26.2 near TNIK (show TNIK Antibodies)
Results show that Meis1 may have a positive feedback with Msi1 (show MSI1 Antibodies) during the esophageal squamous cell carcinoma progression.
Meis1 functions as an important regulator during the progression of acute myeloid leukemia (show BCL11A Antibodies).
MEIS1 drivesMalignant peripheral nerve sheath tumors cell growth via the transcription factor ID1 (show ID1 Antibodies), thereby suppressing expression of the cell cycle inhibitor p27 (show PAK2 Antibodies)(Kip (show CIB1 Antibodies)) and maintaining cell survival.
it was observed that ER stimulated gene expression by interacting with MEIS1 and FOXP3 (show FOXP3 Antibodies), and ER inhibited gene expression by interacting with THRB (show THRB Antibodies) and GRHL1 (show GRHL1 Antibodies).
The Ubx cofactor, Homothorax (Hth), was co-enriched with Ubx near enhancers that require Hth, even though Ubx and Hth did not co-localize throughout the nucleus. Thus, microenvironments of high local transcription factor and cofactor concentrations could help low-affinity sites overcome their kinetic inefficiency.
Hth+Tsh-induced tissue overgrowth requires the BMP2 (show BMP2 Antibodies) Dpp (show TGFb Antibodies) and the abnormal hyperactivation of its pathway. Rather than using autocrine Dpp (show TGFb Antibodies) expression, Hth+Tsh cells increase their avidity for Dpp (show TGFb Antibodies), produced locally, by upregulating extracellular matrix components.
the satellite repeats get transcribed in wild type embryos and that this transcription depends on the presence of Hth, which binds to them as well as to the ribosomal DNA region.
The retinal determination gene Dachshund restricts cell proliferation by limiting the activity of the Homothorax-Yorkie (show YAP1 Antibodies) complex
Hth functions together with its co-factor Extradenticle to repress the R8-specific factor Senseless in dorsal rim (show RBBP8 Antibodies) area R8 cells, allowing expression of an ultraviolet-sensitive R7 Rhodopsin (show RHO Antibodies).
Functional dissection of the splice variants of the Drosophila gene homothorax (hth
Data indicate that loss of Lethal giant larvae (Lgl) tumor suppressor in the wing primordium induced epithelial neoplasia in its Homothorax (Hth)-expressing proximal domain.
cooperative binding sites for En, with the homeodomain-containing Hox (show MSH2 Antibodies) cofactors Extradenticle (Exd) and Homothorax (Hth) was localized, within two CRMs that drive similar expression patterns
Hox (show MSH2 Antibodies) genes and homothorax are required for motoneuron survival.
In the flight muscles, exd and hth are genetically upstream of another muscle identity gene, salm, and are direct transcriptional regulators of the signature flight muscle structural gene, Actin88F.
Data indicate that MiR (show MYLIP Antibodies)-144 regulates primitive hematopoiesis through repression of meis1 during embryogenesis.
Loss of meis1 is associated with impaired hematopoiesis as well as vascular development.
This study demonistrated that Meis1 plays an important role in establishing the retinotectal map and organizing the visual system in zebrafish.
The Hox (show MSH2 Antibodies) cofactor Meis1 acts upstream of gata1 (show GATA1 Antibodies) to regulate primitive hematopoiesis.
Results implicate meis1 as a positive cell cycle regulator in early retinal cells, and provide evidence of an evolutionary conserved function for Hth/Meis genes in the maintenance of the proliferative, multipotent cell state during early eye development.
These results implicate that meis1 is a novel regulator involved in endothelial cell development, presumably affecting the vegf (show VEGFA Antibodies) signaling pathway.
Data show that Irx7 and Irx1b are required for the proper formation and specification of rhombomeres 1 to 4, and that Irx7 functionally interacts with Meis1.1 to activate the expression of anterior hindbrain markers, such as krox20 (show EGR2 Antibodies).
the role of Meis1 in sensorimotor gating and in the dopaminergic systems modulating it, is reported.
Results show Meis1 Is expressed in normal and aberrant ducts, pancreatic intraepithelial neoplasia, and pancreatic ductal adenocarcinoma and that its expression increases cell migration in pancreatic cancer through transcriptional activation of Mcam (show MCAM Antibodies).
the Hoxa9 (show HOXA9 Antibodies)- and Meis1-associated upregulation of Flt3 (show FLT3 Antibodies) is a passive event with regard to leukemia development in mice and with limited relevance to the AML (show RUNX1 Antibodies) pathology.
We found that expression of Emx2 (show EMX2 Antibodies) and Lhx2 (show LHX2 Antibodies) initiated between neuronal progenitor and neuronal precursor stages. As far as the sensory neurons of the vomeronasal organ are concerned, Meis1 and Meis2 (show MEIS2 Antibodies) were only expressed in the apical layer, together with Gnai2 (show GNAI2 Antibodies), but not in the basal layer.
we show that simultaneous deletion of Meis1 and Meis2 (show MEIS2 Antibodies) in presumptive lens ectoderm results in arrested lens development in the pre-placodal stage, and neither lens placode nor lens is formed. We found that in the presumptive lens ectoderm of Meis1/Meis2 (show MEIS2 Antibodies) deficient embryos Pax6 (show PAX6 Antibodies) expression is absent
Meis1 is a major regulator of sympathetic target-field innervation and Meis1 deficient sympathetic neurons die by apoptosis from early embryonic stages to perinatal stages.
PCBP2 (show PCBP2 Antibodies) overexpression rescues the Meis1 effects of Akt (show AKT1 Antibodies)-mTOR (show FRAP1 Antibodies) pathway and hypertrophy of cardiomyocytes.
Data indicate roles of myeloid ecotropic viral integration site 1 protein (Meis1) in both megakaryopoiesis and erythropoiesis.
Tumorigenesis by Meis1 overexpression is accompanied by a change of DNA target-sequence specificity which allows binding to the AP-1 (show JUN Antibodies) element.
Sequential binding of MEIS1 and NKX2-5 (show NKX2-5 Antibodies) on the Popdc2 (show POPDC2 Antibodies) gene demonstrate a mechanism for spatiotemporal regulation of enhancers during cardiogenesis.
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.
Meis1, myeloid ecotropic viral integration site 1 homolog
, homeobox protein Meis1
, leukemogenic homolog protein
, XMeis1-2 protein
, Meis homeobox 1
, gene II
, homeobox protein Meis1-like
, myeloid ecotropic viral integration site 1
, myeloid ecotropic viral insertion site-1a protein