Browse our PC4 and SFRS1 Interacting Protein 1 Proteins (PSIP1)

Full name:: PC4 and SFRS1 Interacting Protein 1 Proteins (PSIP1)

On www.antibodies-online.com are 10 PC4 and SFRS1 Interacting Protein 1 (PSIP1) Proteins from 0 different suppliers available. A total of 76 PC4 and SFRS1 Interacting Protein 1 products are currently listed.

Synonyms:: AA408851, AU015605, Dfs70, im:7149861, Ledgf, LEDGF/p75, Ledgfa, Ledgfb, p52, p75, PAIP, PSIP1, Psip2, SBP75, zgc:109898

list all proteins	Gene Name	GeneID	UniProt
Human PSIP1	PSIP1	11168	O75475
Mouse PSIP1	PSIP1	101739	Q99JF8
Rat PSIP1	PSIP1	313323	Q812D1
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Human PC4 and SFRS1 Interacting Protein 1 (PSIP1) interaction partners

findings suggest a novel role of LEDGF/p75 in protecting the unintegrated 3' processed linear HIV-1 cDNA from exonucleolytic degradation.
mono-specific anti-DFS70 antibodies are a strong discriminator between ANA (show BTG3 Proteins) positive healthy controls and patients with systemic autoimmune rheumatic diseases.
Authors report here that the endogenous levels of LEDGF/p75 are upregulated in metastatic castration resistant prostate cancer (mCRPC) cells selected for resistance to the taxane drug docetaxel (DTX (show DTX1 Proteins)).
An important role of PSIP1 in triple negative breast cancer tumorigenicity by promoting the expression of genes that control the cell cycle and tumor metastasis
We identify the Myc (show MYC Proteins)-interacting protein JPO2 (show CDCA7L Proteins) and its partner binding protein LEDGF/p75 as critical modulators of PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling and metastasis in medulloblastoma
The association of LEDGF proteins with the FACT complex and give further support to a role of SSRP1 (show SSRP1 Proteins) in HIV-1 infection.
short isoform (p52 (show FKBP4 Proteins)) of a transcriptional co-activator-PC4 (show IFRD1 Proteins) and SF2 (show SRSF1 Proteins) interacting protein (Psip1), which is known to be involved in linking transcription to RNA processing, specifically regulates the expression of the lncRNA Hottip-located at the 5' end of the Hoxa locus
Germline polymorphisms in an enhancer of PSIP1 are associated with epithelial ovarian cancer.
PSIP1 likely plays an important role in Hereditary Hearing Loss.
LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced (show SQSTM1 Proteins) Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 (show PDIA3 Proteins) in Prostate Cancer

Mouse (Murine) PC4 and SFRS1 Interacting Protein 1 (PSIP1) interaction partners

PSIP1 likely plays an important role in Hereditary Hearing Loss.
The role of Psip1 in cardiac development
conclude that small peptides disrupting the LEDGF/p75-MLL (show MLL Proteins) interface have selective anti-leukemic activity providing a direct rationale for the design of small molecule inhibitors targeting this interaction
Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.
Alcohol (ADH (show AVP Proteins)) and ALDH (show ALDH3A1 Proteins) dehydrogenases are implicated in cellular detoxification and conversion of vitamin A to RA. Lens epithelium-derived growth factor provides cellular protection against stress by transactivating stress-associated genes.
Results suggest that TNF-alpha (show TNF Proteins) elevates the expression of lens epithelium-derived growth factor (LEDGF) and that LEDGF is one of the transactivators of gamma-glutamylcysteine synthetase heavy subunit (show GCLC Proteins) gene.
These suggest a role for Psip1 in the control of Homeobox (show PRRX1 Proteins) expression and may also explain why PSIP1 (LEDGF) is found as a fusion partner with NUP98 (show NUP98 Proteins) in myeloid leukemias.
some DFS70-positive sera have antibodies that recognize antigens of the lens

PC4 and SFRS1 Interacting Protein 1 (PSIP1) Protein Profile

Protein Summary

Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity).

Alternative names and synonyms associated with PC4 and SFRS1 Interacting Protein 1 (PSIP1)

PC4 and SFRS1 interacting protein 1 S homeolog (psip1.S)
PC4 and SFRS1 interacting protein 1 (PSIP1)
PC4 and SFRS1 interacting protein 1a (psip1a)
PC4 and SFRS1 interacting protein 1 (psip1)
LEDGF/p75 transcription factor-like (psip1)
PC4 and SFRS1 interacting protein 1 (Psip1)

AA408851 protein
AU015605 protein
Dfs70 protein
im:7149861 protein
Ledgf protein
LEDGF/p75 protein
Ledgfa protein
Ledgfb protein
p52 protein
p75 protein
PAIP protein
PSIP1 protein
Psip2 protein
SBP75 protein
zgc:109898 protein

Protein level used designations for PSIP1

, , , , , , , , , , , , , , , , , , PC4 and SFRS1 interacting protein 1 LEDGF/p75 PC4 and SFRS1-interacting protein PC4 and SFRS1-interacting protein-like protein Lens epithelium-derived growth factor PC4 and SFRS1-interacting protein-like putative LEDGF/p75 transcription factor lens epithelium-derived growth factor CLL-associated antigen KW-7 DFS 70 dense fine speckles 70 kDa protein transcriptional coactivator p52/p75 transcriptional coactivator p75/p52 PC4 and SFRS1 interacting protein 2 dense fine speckles 70 mLEDGF supercoiled DNA binding protein 75 lens epithelium derived growth factor p75 transcription coactivator p75

GENE ID	SPECIES
398545	Xenopus laevis
465001	Pan troglodytes
553760	Danio rerio
100016299	Monodelphis domestica
100034217	Equus caballus
100145476	Xenopus (Silurana) tropicalis
100195391	Salmo salar
100230181	Taeniopygia guttata
100233239	Ovis aries
100339871	Oryctolagus cuniculus
100401055	Callithrix jacchus
100584230	Nomascus leucogenys
734236	Xenopus laevis
431605	Gallus gallus
11168	Homo sapiens
474712	Canis lupus familiaris
282011	Bos taurus
101739	Mus musculus
313323	Rattus norvegicus
493969	Felis catus

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