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Data show that three SNPs (rs9933638, rs12443621, and rs3104746) at the TOX3/LOC643714 locus contributed to lung cancer risk, suggesting that lung cancer and breast cancer are linked at the molecular and genetic level to a certain extent.
Data support a plausible molecular mechanism integrating epigenetic modifications of the TOX3 promoter and allele specific expression of SNPs in aggressive behavior of luminal breast tumors with high TOX3 expression.
Significant associations were observed between Breast Cancer risk and two Single nucleotide polymorphisms of FGFR2 (show FGFR2 Proteins) [rs2981582 (P=0.005), rs1219648 (P=9.08e006)] and one Single nucleotide polymorphisms of TNRC9 [rs3803662) (P=0.012)] in Pakistani women.
The genotype of rs3803662 from TOX3 is associated with breast cancer.
The TNRC9 rs3803662 C>T polymorphism is greatly related to increased risk of breast cancer, in both Asian and Caucasian populations.
TNRC9 GG genotype of rs3803662 is associated with increased breast cancer risk.
The TOX3 SNPs rs3803662 C > T, rs12443621 A > G and rs8051542 C > T were all correlated with increased risk of breast cancer in the European and Asian populations, but not in the African one.
TOX3 and FGFR2 are breast cancer susceptibility genes in BRCA1/2-wild-type breast cancer patients from Sardinian population.
TOX3 is expressed in mammary ER(+) epithelial cells and regulates ER target genes in luminal breast cancer
Single nucleotide polymorphism in TOX3 gene is associated with breast cancer risk.
A role of Tox3 in the development of the nervous system.
data suggest that central inhibition of IL-1alpha or Tox3 overexpression during the acute phase of a CNS insult may be an effective means for preventing the loss of neurological function
TNRC9 gene is amplified and associated with poor prognosis in advanced breast cancer. TNRC9 promotes cancer cell proliferation, migration, and survival both in vitro and in vivo. TNRC9 and BRCA1 expression are inversely correlated.
The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.
TOX high mobility group box family member 3
, trinucleotide repeat containing 9
, TOX high mobility group box family member 3-like
, CAG trinucleotide repeat-containing gene F9 protein
, trinucleotide repeat-containing gene 9 protein