Browse our C1S Proteins (C1S)

Full name:: Complement Component 1, S Subcomponent Proteins (C1S)

On www.antibodies-online.com are 11 Complement Component 1, S Subcomponent (C1S) Proteins from 6 different suppliers available. Additionally we are shipping C1S Antibodies (138) and C1S Kits (18) and many more products for this protein. A total of 171 C1S products are currently listed.

Synonyms:: AA959438, AI255193, AI327365, C1S, C1sa, r-gsp

list all proteins	Gene Name	GeneID	UniProt
	C1S	716	P09871
	C1S	50908	Q8CG14
	C1S	192262	Q6P6T1
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Relevant Pathways for C1S Proteins

Complement System

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Human Complement Component 1, S Subcomponent (C1S) interaction partners

The serine protease (show F2 Proteins) domains of C1r (show C1R Proteins) and C1s are at the periphery of the C1r2s2 tetramer both when alone or within the nonactivated C1 complex. The C1 complex adopts a conformation incompatible with intramolecular activation of C1. Instead, intermolecular proteolytic activation between neighboring C1 complexes bound to a complement-activating surface occurs. Many structurally unrelated molecular patterns can activate C1.
Periodontal Ehlers-Danlos Syndrome in at least the great majority of cases results from specific classes of heterozygous mutations in C1R (show C1R Proteins) and C1S.
C1q exists as the C1 complex (C1qC1r2C1s2), and C1q binding to ligands activates the C1r (show C1R Proteins)/C1s proteases. Incubation of nucleoli with C1 caused degradation of the nucleolar proteins nucleolin (show NCL Proteins) and nucleophosmin 1 (show NPM1 Proteins). T
Data indicate that complement C1s mRNA level was low in ICR-derived glomerulonephritis (ICGN) mice liver as compared with age-matched ICR mice.
Analysis of its interaction properties by surface plasmon resonance shows that rC1q retains the ability of serum C1q to associate with the C1s-C1r-C1r (show C1R Proteins)-C1s tetramer, to recognize physiological C1q ligands such as IgG and pentraxin 3 (show PTX3 Proteins)
A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4.
Four positively charged amino acids on the serine protease (show F2 Proteins) domain appear to form a catalytic exosite that is required for efficient cleavage of C4 in the classical pathway of complement.
These results provide further structural insights into the architecture of the C1 complex, and the interactions between C1r (show C1R Proteins) and C1s.
Detailed mapping of post-translational modifications and insights into the C1r (show C1R Proteins)/C1s binding sites.
Interaction with the prime side residues at the cleavage point in C1s enhances the affinity of the enzyme for complement 2 and complement 4 substrates; these prime subsite residues mediate positive cooperativity in the cleavage of the substrate.

Mouse (Murine) Complement Component 1, S Subcomponent (C1S) interaction partners

C1r (show C1RA Proteins) and this gene are duplicated in mice; differential expression generates alternative isomorphs in the liver and in the male reproductive system.

C1S Protein Profile

Protein Summary

This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency.

Alternative names and synonyms associated with C1S

complement C1s (C1S)
complement component 1, s subcomponent 1 (C1s1)
complement C1s (C1s)
complement component 1, s subcomponent (c1s)
complement component 1, s subcomponent L homeolog (c1s.L)
complement C1s subcomponent (LOC100558615)

AA959438 protein
AI255193 protein
AI327365 protein
C1S protein
C1sa protein
r-gsp protein

Protein level used designations for C1S

C1 esterase , basic proline-rich peptide IB-1 , complement C1s subcomponent , complement component 1 subcomponent s , complement C1s-A subcomponent , complement component 1 subcomponent s-A , complement component C1SA , serine protease , complement component C1s , complement component 1, s subcomponent , complement C1s subcomponent-like

GENE ID	SPECIES
716	Homo sapiens
50908	Mus musculus
192262	Rattus norvegicus
397274	Sus scrofa
418294	Gallus gallus
451808	Pan troglodytes
486714	Canis lupus familiaris
613055	Xenopus (Silurana) tropicalis
714589	Macaca mulatta
733422	Xenopus laevis
767827	Bos taurus
100222051	Taeniopygia guttata
100412274	Callithrix jacchus
100455685	Pongo abelii
100549400	Meleagris gallopavo
100558615	Anolis carolinensis
100599399	Nomascus leucogenys

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