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Full name:: Complement Component 4B Proteins (C4B)

On www.antibodies-online.com are 22 Complement Component 4B (C4B) Proteins from 4 different suppliers available. Additionally we are shipping C4B Antibodies (131) and C4B Kits (58) and many more products for this protein. A total of 214 C4B products are currently listed.

Synonyms:: C4, C4-2, C4B, C4B1, C4B2, C4B3, C4B5, C4B12, C4BD, C4B_2, C4F, C4l, CH, CO4, CPAMD3, DKFZP469I0332, Ss, wu:fi14a03

list all proteins	Gene Name	GeneID	UniProt
	C4B	721	P0C0L4 , P0C0L5
	C4B	12268	P01029
Rat C4B	C4B	406161
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C4B Proteins (C4B) by Origin

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Relevant Pathways for C4B Proteins

Complement System

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Human Complement Component 4B (C4B) interaction partners

results suggest that the C4B gene number associates positively with inflammation in patients with PIBD. Multiple copies of the C4B gene may thus aggravate the IBD-associated dysbiosis through escalated complement reactivity towards the microbiota.
An elevated number of C4 genes was observed in Alzheimer's disease (AD) patients as compared with healthy controls. The presence of high C4A and C4B copy numbers in AD patients could explain the increased C4 protein expression observed in AD patients, thus highlighting a possible role for C4A and C4B copy number variations in the risk of developing AD.
The structural basis for inhibition of the classical and lectin complement pathways by S. aureus extracellular adherence protein binding to C4b has been presented.
The aims of this study were to elucidate the copy number variations of C4A and C4B in relation to disease risk in systemic lupus erythematosus, and to compare the basis of race-specific C4A deficiency between East Asians and individuals of European descent
C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus
Data indicate Ig-like transcript 4 (ILT4 (show LILRB2 Proteins)) as a cellular receptor for complement split products (CSPs) complement component 4d (C4d).
Suggest a prominent prognostic value of C4d staining as a rejection marker in ABO compatible kidney transplantation.
The interaction between C4BP (show C4BPA Proteins) and Leptospira interrogans LcpA, LigA and LigB is sensitive to ionic strength and inhibited by heparin.
There was a significant association between C4d deposition on allograft endothelial cells and presence of class II DSA I chronic liver allograft failure.
Carrying no copies of C4B significantly increases the risk of cCSC, whereas carrying three C4B copies is protective.

Mouse (Murine) Complement Component 4B (C4B) interaction partners

These data show that Borrelia burgdorferi OspC inhibits the classical and lectin complement pathways and competes with complement protein C2 for C4b binding.
Data indicate complement C3 (show C3 Proteins) deposition on peanut extract (PE) was abolished in immunoglobulin- and C4-deficient sera.
a deficiency in C4b does not alter radiation-induced lung disease in the C57BL/6 mouse model
C3 and C4 bind to collagen and elastin (show ELN Proteins) in the vascular wall and have a potential role in vascular stiffness and atherosclerosis
Complement C4 provides an important protective role against the development of systemic lupus erythematosus.
identified the murine follicular dendritic cell marker, FDC-M2, as complement c4. FDC-M2 was detectable at sites of immune complex-mediated inflammatory disease
The increased mortality of C4(-/-) or Factor B (show CFB Proteins)(-/-) mice indicates that these two pathways of complement activation are required for survival in mousepox.
Increased transcription of the complement C4 gene in the Rag1 (show RAG1 Proteins)(-/-) intestine.

C4B Protein Profile

Protein Summary

This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.

Alternative names and synonyms associated with C4B

complement C4B (Chido blood group) (C4B)
complement component 4 (c4)
complement C4-B (LOC462577)
complement component 4B (Chido blood group) (C4B)
complement component 4B (Chido blood group) (C4b)
complement C4B (Chido blood group) (C4b)

C4 protein
C4-2 protein
C4B protein
C4B1 protein
C4B2 protein
C4B3 protein
C4B5 protein
C4B12 protein
C4BD protein
C4B_2 protein
C4F protein
C4l protein
CH protein
CO4 protein
CPAMD3 protein
DKFZP469I0332 protein
Ss protein
wu:fi14a03 protein

Protein level used designations for Complement Component 4B Proteins (C4B)

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3 , Chido form of C4 , basic complement C4 , complement C4-B , complement C4B1a , complement component 4A , complement component 4B , complement component 4B (Chido blood group) , complement component 4 (within H-2S) , complement component 4B (Childo blood group) , complement C4-like protein , complement component 4, gene 2

GENE ID	SPECIES
721	Homo sapiens
566261	Danio rerio
462577	Pan troglodytes
100171517	Pongo abelii
12268	Mus musculus
406161	Rattus norvegicus

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