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Human CD59 Protein expressed in Human Cells - ABIN2005233
Fletcher, Harrison, Lachmann, Neuhaus: Structure of a soluble, glycosylated form of the human complement regulatory protein CD59. in Structure (London, England : 1993) 1994
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we demonstrated that CD59 regulation by SOX2 (show SOX2 Proteins) is required for stem cell evasion of complement surveillance. This finding highlights the importance of complement surveillance in eliminating CSCs and may suggest CD59 as a potential target for cancer therapy.
The results indicate that shear stress is an important mediator in endothelial progenitor cells expression of CD59 regulated by the extacellular matrix-integrin alphaVbeta3-F-actin pathway, which is a key factor in preventing membrane attack complex-mediated cell autolysis.
Data show that following 4 patients with CD59 Cys89Tyr mutations who are treated with eculizumab, no strokes occurred and non-permanent neurological insults underwent resolution without any new neurological exacerbations.
our results indicate that the Lys (show LYZ Proteins)(41) /His(44) glycation motif in human CD59 may confer humans a higher risk of developing vascular disease in response to hyperglycemia.
Structural basis for receptor recognition by the human CD59-responsive cholesterol-dependent cytolysins has been presented.
developed a model of conditional and targeted cell ablation by generating floxed STOP-CD59 knockin mice (ihCD59), in which expression of human CD59 only occurs after Cre-mediated recombination
Our results revealed that SNPs CD59-rs831626 and CFH (show CFH Proteins)-rs1065489 were associated with the susceptibility of acute anterior uveitis.
Novel disorder caused by CD59 deficiency or nonfunctional CD59 at the cell membrane presenting with symptoms characteristic of classical GBS (show GNB5 Proteins) or CIDP.
Single-fluorescent-molecule imaging in the live-cell plasma membrane revealed the clear but transient colocalization and codiffusion of fluorescent ganglioside analogs with a fluorescently labeled glycosylphosphatidylinisotol (GPI (show GNPDA1 Proteins))-anchored protein, human CD59, with lifetimes of 12 ms for CD59 monomers, 40 ms for CD59's transient homodimer rafts in quiescent cells.
There is an altered pattern of CD55 (show CD55 Proteins) and CD59 expression on RBCs (show SSU1 Proteins) of SCD (show SCD Proteins) Patients; however, it does not seem to play a causal role in the pathophysiology of anemia, and is unlikely to be influenced by the level of erythropoietin (show EPO Proteins) or other inflammatory mediators.
Varicella-zoster virus infection upregulates host CD59 expression in a tissue-specific manner.
This study support a role of Cd59a in controlling the innate immune status of the RPE (show RPE Proteins)-choroidal complex and emphasizes the particular vulnerability of this ocular compartment to the dysregulation of alternative complement pathway during aging
results implicate CD59 as an important modulator of the immune response in NMO, and provide a novel animal model of NMO that closely recapitulates human NMO pathology.
Soluble forms of CD59 (sCD59) have been investigated in mouse laser-induced choroidal neovascularization, a model for "wet" age related macular degeneration.
both CD59 and C-PC could inhibit the progress of atherosclerosis, and the anti-atherosclerotic effects of C-PC might be fulfilled by promoting CD59 expression, preventing smooth muscle cell proliferation and the apoptosis of endothelial cells
CD59a inhibits systemic autoimmunity in MRL/lpr (show FAS Proteins) mice through a complement-independent mechanism.
While the connection between CFH (show CFH Proteins) deficiency and failure to upregulate CD59a remains unknown, these results suggest that expression of CD59 is tissue-specific and that neuroretinal regulation depends on CFH (show CFH Proteins).
Actively immunized experimental autoimmune myasthenia gravis mice deficient in either CD55 (show CD55 Proteins) or CD59 showed significant differences in adaptive immune responses and worsened disease outcome associated with increased levels of serum cytokines, modified production of acetylcholine receptor (show CHRNB1 Proteins) antibodies, and more complement deposition at the neuromuscular junction.
HBx can up-regulate CD59 and Crry (show CR1L Proteins) expression in podocytes through activating the P38 (show CRK Proteins) pathway.
CD59 has a role in growth of the choroidal neovascular complex in mice
Data demonstrate that the resistance of neonatal porcine Sertoli cells to human xenoantibody and complement-mediated lysis is associated with low expression of xenoantigen alpha-Gal and high production of the complement inhibitors clusterin (show CLU Proteins) and CD59.
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
, 20 kDa homologous restriction factor
, CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)
, CD59 glycoprotein
, Ly-6-like protein
, MEM43 antigen
, T cell-activating protein
, human leukocyte antigen MIC11
, lymphocytic antigen CD59/MEM43
, membrane attack complex (MAC) inhibition factor
, membrane attack complex inhibition factor
, membrane inhibitor of reactive lysis
, surface anitgen recognized by monoclonal antibody 16.3A5
, CD59 antigen
, CD59A glycoprotein
, MAC-inhibitory protein
, CD59b moleucle, complement regulatory protein
, Cb59b molecule
, CD59 homolog
, CD59 molecule, complement regulatory protein