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Human CD59 Protein expressed in Human Cells - ABIN2005233
Fletcher, Harrison, Lachmann, Neuhaus: Structure of a soluble, glycosylated form of the human complement regulatory protein CD59. in Structure (London, England : 1993) 1994
Show all 4 Pubmed References
Identification of c.238 A>G (p.Arg80Gly) of CD59 blood group gene.
Authors found that the CD59 glycoprotein precursor was aberrantly upregulated in the ERalpha-negative breast cancer MCF-10A cells but not the MCF-7 cells. Furthermore, the CD59 glycoprotein precursor expression was elevated in the TAM-resistant breast cancer cells.
Parainfluenza Virus 5 (PIV5) containing CD59 antigens (PIV5-CD59) shows increased resistance to complement-mediated neutralization in vitro comparing to PIV5 lacking regulators. Infection of A549 cells with PIV5 upregulates CD59 expression. TGF-beta treatment of PIV5-infected cells also increases cell surface CD59 expression and progeny virions are more resistant to complement-mediated neutralization.
Nonfunctioning CD59 is a major risk factor for stroke and hypercoagulability.
Therapeutic strategies that seek to modulate the functions of CD59 in the tumor microenvironment could be a promising direction for tumor immunotherapy.
This study demonstrated that Diffuse microvascular C5b-9 deposition is a common feature in muscle and nerve biopsies from diabetic patients.
Movement of Domain 2 with respect to Domain 3 of ILY is essential for forming a late prepore intermediate that releases CD59, while the role of cholesterol may be limited to insertion of the transmembrane segments. Together these data define a structural timeline for ILY pore formation and suggest a mechanism that is relevant to understanding other pore-forming toxins that also require CD59.
CD59 polymorphisms are associated with gene expression and different sexual susceptibility to pemphigus foliaceus in the Brazilian patients.
we demonstrated that CD59 regulation by SOX2 is required for stem cell evasion of complement surveillance. This finding highlights the importance of complement surveillance in eliminating CSCs and may suggest CD59 as a potential target for cancer therapy.
The results indicate that shear stress is an important mediator in endothelial progenitor cells expression of CD59 regulated by the extacellular matrix-integrin alphaVbeta3-F-actin pathway, which is a key factor in preventing membrane attack complex-mediated cell autolysis.
Data show that following 4 patients with CD59 Cys89Tyr mutations who are treated with eculizumab, no strokes occurred and non-permanent neurological insults underwent resolution without any new neurological exacerbations.
our results indicate that the Lys(41) /His(44) glycation motif in human CD59 may confer humans a higher risk of developing vascular disease in response to hyperglycemia.
Structural basis for receptor recognition by the human CD59-responsive cholesterol-dependent cytolysins has been presented.
developed a model of conditional and targeted cell ablation by generating floxed STOP-CD59 knockin mice (ihCD59), in which expression of human CD59 only occurs after Cre-mediated recombination
Our results revealed that SNPs CD59-rs831626 and CFH-rs1065489 were associated with the susceptibility of acute anterior uveitis.
Novel disorder caused by CD59 deficiency or nonfunctional CD59 at the cell membrane presenting with symptoms characteristic of classical GBS or CIDP.
Single-fluorescent-molecule imaging in the live-cell plasma membrane revealed the clear but transient colocalization and codiffusion of fluorescent ganglioside analogs with a fluorescently labeled glycosylphosphatidylinisotol (GPI)-anchored protein, human CD59, with lifetimes of 12 ms for CD59 monomers, 40 ms for CD59's transient homodimer rafts in quiescent cells.
There is an altered pattern of CD55 and CD59 expression on RBCs of SCD Patients; however, it does not seem to play a causal role in the pathophysiology of anemia, and is unlikely to be influenced by the level of erythropoietin or other inflammatory mediators.
Study revealed that CD59 is overexpressed in breast cancer tumors and correlates with poor survival.
A Promoter Polymorphism in the CD59 Gene in Donor Lungs Correlates With a Higher Risk for Chronic Rejection After Lung Transplantation.
Data demonstrate that the resistance of neonatal porcine Sertoli cells to human xenoantibody and complement-mediated lysis is associated with low expression of xenoantigen alpha-Gal and high production of the complement inhibitors clusterin and CD59.
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
, 20 kDa homologous restriction factor
, CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)
, CD59 glycoprotein
, Ly-6-like protein
, MEM43 antigen
, T cell-activating protein
, human leukocyte antigen MIC11
, lymphocytic antigen CD59/MEM43
, membrane attack complex (MAC) inhibition factor
, membrane attack complex inhibition factor
, membrane inhibitor of reactive lysis
, surface anitgen recognized by monoclonal antibody 16.3A5
, CD59 antigen
, CD59b moleucle, complement regulatory protein
, Cb59b molecule
, MAC-inhibitory protein
, CD59 homolog
, CD59 molecule, complement regulatory protein