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blockade of KLK10 attenuates epithelial-mesenchymal transition and activation of FAK (show PTK2 Proteins)-SRC (show SRC Proteins)-ERK (show EPHB2 Proteins) signaling, which explains the mechanism of KLK10 in promoting metastasis.
To the best of our knowledge, this is the first report on KLK10 exon 3 unmethylated PCR product concentration as potential early epigenetic diagnostic marker in primary ovarian tumors.
KLK10 was verified to be a potential therapeutic target for reversing trastuzumab resistance in breast cancer cells.
Pronounced correlations between KLK10/KLK11 (show KLK11 Proteins) (rs = 0.647) and between KLK9 (show KLK9 Proteins)/KLK15 (show KLK15 Proteins) (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases
identification and molecular cloning of eight novel transcripts of the human KLK10 gene using 3' rapid amplification of cDNA ends (3' RACE) and next-generation sequencing (NGS), as well as their expression analysis in a wide panel of cell lines, originating from several distinct cancerous and normal tissues
Data suggest that mature KLK9 (kallikrein 9 (show KLK9 Proteins)) is a glycosylated chymotrypsin-like enzyme with strong preference for tyrosine over phenylalanine at P1 cleavage position; substrate specificity of KLK9 (show KLK9 Proteins) appears to extend to KLK10 and midkine (show MDK Proteins); enzyme activity is enhanced by Mg2 (show MUC7 Proteins)+ and Ca2 (show CA2 Proteins)+, but is reversibly attenuated by Zn2+; KLK9 (show KLK9 Proteins) is inhibited in vitro by many naturally occurring or synthetic protease inhibitors.
KLK10 potentially plays a crucial role in esophageal cancer cell growth.
KLK10 may function as a tumour suppressor by repressing proliferation, enhancing apoptosis and decreasing glucose metabolism in PC3 (show PCSK1 Proteins) cells.
treated and untreated prolactin (show PRL Proteins)-producing pituitary adenomas and carcinomas as well as TSH-producing pituitary adenomas and carcinomas were conclusively immunopositive for KLK10
Immunoexpression of KLK10 in the ACTH (show POMC Proteins)-secreting tumors as well as in the Crooke cell tumors was significantly increased when compared with the nonfunctioning tumors and in the corticotrophs of non-tumorous pituitaries.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.
kallikrein-related peptidase 10
, kallikrein 10
, breast normal epithelial cell associated serine protease
, normal epithelial cell-specific 1
, protease serine-like 1
, protease, serine-like, 1