Browse our Kallikrein 14 Proteins (KLK14)

Human Kallikrein 14 (KLK14) interaction partners

1. In this work, KLK14 binding to either hepatocyte growth factor activator inhibitor type-1 (HAI-1 (show SPINT1 Proteins)) or type-2 (HAI-2 (show SPINT2 Proteins)) was essayed using homology modeling, molecular dynamic simulations and free-energy calculations through MM/PBSA and MM/GBSA. KLK14 was successfully modeled.

2. increased KLK14 activity could contribute at multiple levels to HGF (show HGF Proteins)/Met-mediated processes in prostate and other cancers

3. KLK7 (show KLK7 Proteins) and KLK14 gene expression can be regarded as markers of poor prognosis for colorectal cancer patients with discriminating power between CC and adenoma patients.

4. genetic variants in the KLK14 locus are associated with risk and/or aggressiveness of prostate cancer

5. KLK14, acting via PAR-2 (show F2RL1 Proteins), represents an autocrine/paracrine regulator of colon tumorigenesis

6. KLK8 (show KLK8 Proteins) and KLK14 can signal differentially via the PARs (show EPRS Proteins) to affect tissue function

7. KLK14 gene expression could be evaluated as a putative independent diagnostic biomarker in breast tumour biopsies.

8. The differences in the levels of KLK14 suggest that KLKs may aid in the differential diagnosis of salivary gland tumors. The coexpression of KLKs suggests their possible involvement in an enzymatic pathway activated in salivary gland.

9. KLK14 overexpression was found to be a significant predictor of decreased disease-free survival and overall survival in breast cancer patients

10. KLK14 expression upregulated in advanced and more aggressive prostate tumors; may play role in tumor spread and may be new marker for prostate cancer diagnosis and prognosis