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There was no significant association of KLK13 (show KLK13 Proteins) and KLK14 mRNA expression with the clinical factors ascitic fluid volume or residual tumor mass. High KLK14 mRNA levels were significantly associated with prolonged PFS (HR = 0.44, P = 0.017) and showed a trend towards significance for OS (HR = 0.55, P = 0.070).
In this work, KLK14 binding to either hepatocyte growth factor activator inhibitor type-1 (HAI-1 (show SPINT1 Proteins)) or type-2 (HAI-2 (show SPINT2 Proteins)) was essayed using homology modeling, molecular dynamic simulations and free-energy calculations through MM/PBSA and MM/GBSA. KLK14 was successfully modeled.
increased KLK14 activity could contribute at multiple levels to HGF (show HGF Proteins)/Met-mediated processes in prostate and other cancers
KLK7 (show KLK7 Proteins) and KLK14 gene expression can be regarded as markers of poor prognosis for colorectal cancer patients with discriminating power between CC and adenoma patients.
genetic variants in the KLK14 locus are associated with risk and/or aggressiveness of prostate cancer
KLK14, acting via PAR-2 (show F2RL1 Proteins), represents an autocrine/paracrine regulator of colon tumorigenesis
KLK8 (show KLK8 Proteins) and KLK14 can signal differentially via the PARs (show EPRS Proteins) to affect tissue function
KLK14 gene expression could be evaluated as a putative independent diagnostic biomarker in breast tumour biopsies.
The differences in the levels of KLK14 suggest that KLKs may aid in the differential diagnosis of salivary gland tumors. The coexpression of KLKs suggests their possible involvement in an enzymatic pathway activated in salivary gland.
KLK14 overexpression was found to be a significant predictor of decreased disease-free survival and overall survival in breast cancer patients
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. An additional transcript variant has been described but its full length nature has not been determined.
glandular kallikrein KLK14
, kallikrein 14
, kallikrein-like protein 6