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Mouse (Murine) PLG Protein expressed in Mouse - ABIN491397
Bruno, Cuello: Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade. in Proceedings of the National Academy of Sciences of the United States of America 2006
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Human PLG Protein expressed in Human - ABIN491018
Komissarov, Florova, Idell: Effects of extracellular DNA on plasminogen activation and fibrinolysis. in The Journal of biological chemistry 2011
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Mouse (Murine) PLG Protein expressed in Mouse - ABIN491392
Van Den Broeck, Stevenaert, Taveirne, Debacker, Vangestel, Vandekerckhove, Taghon, Matthys, Plum, Held, Dewerchin, Yokoyama, Leclercq: Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator. in Blood 2008
Show all 2 Pubmed References
Horse (Equine) PLG Protein expressed in Horse - ABIN780187
Velineni, Timoney: Characterization and protective immunogenicity of the SzM protein of Streptococcus zooepidemicus NC78 from a clonal outbreak of equine respiratory disease. in Clinical and vaccine immunology : CVI 2013
Cow (Bovine) PLG Protein expressed in Cow - ABIN491395
Coy, Jiménez-Movilla, García-Vázquez, Mondéjar, Grullón, Romar: Oocytes use the plasminogen-plasmin system to remove supernumerary spermatozoa. in Human reproduction (Oxford, England) 2012
A rare non-conservative missense mutation was newly identified in exon 9 of the PLG gene.
Plasminogen binds to the cell surface-exposed proteins of Candida parapsilosis.
plasmin cleaves surface-bound CCL21 (show CCL21 Proteins) to release the C-terminal peptide responsible for CCL21 (show CCL21 Proteins) binding to glycosaminoglycans on the extracellular matrix and cell surfaces, thereby generating the soluble form.
Analysis of plasminogen genetic variants in multiple sclerosis patients has been reported.
Enolase of Mtb (show NCAPG2 Proteins) is present on its surface and binds human plasminogen with high affinity.
Data suggest that protein aggregates interact with tissue-type plasminogen activator (show PLAT Proteins) and plasminogen to efficiently generate plasmin; this aggregate-bound plasmin is shielded from inhibition by alpha-2-antiplasmin (show Alpha2 Antiplasmin Proteins) and degrades protein aggregates to release smaller, soluble but relatively hydrophobic peptide fragments; these fragments bind to and are cytotoxic to microglia (by not vascular endothelial cells).
The mechanism for plasminogen/M protein binding uncovered here may facilitate targeting of group A Streptococcus pyogenes virulence factors for disease management
t-PA (show PLAT Proteins) binds to Lys91 in the MBP (show MBL2 Proteins) NH2-terminal region and PLG binds to Lys122 in the MBP (show MBL2 Proteins) COOH-terminal region. This proximity promotes the activation of PLG by t-PA (show PLAT Proteins).
in the presence of platelet polyphosphate and the downstream substrate fibrin, alphaFXIIa is a highly efficient and favorable plasminogen activator.
Plasmin(ogen) serves as a favorable biomarker for prediction of survival in advanced high-grade serous ovarian cancer
The plasminogen/plasminogen activator/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte.
The current study suggests the existence of an active TNF-alpha (show TNF Proteins)-plasminogen-plasmin autocrine/paracrine loop on the massively infiltrated polymorphonuclear neutrophils inside udders of drying-off cows.
examination of interaction with streptococcal plasminogen activator PauA
Variation in blood plasminogen levels, within the range seen in normal individuals, had marked effects on experimental ischemic brain injury
plasmin protease activity prevents dystrophic calcification within injured skeletal muscle independent of its canonical fibrinolytic function.
Plasminogen-deficient mice have extensive fibrin and neutrophil depositions in the wounded area long after re-epithelialisation, indicating inefficient debridement and chronic inflammation. Delayed formation of granulation tissue suggests that fibroblast function is impaired in the absence of plasminogen.
confirmed the ability of Plg/Pla to both promote efferocytosis and override the prosurvival effect of LPS (show TLR4 Proteins) via annexin A1 (show ANXA1 Proteins).
findings identify plasmin as a decisive checkpoint in the inflammatory response during Macrophage activation syndrome (MAS (show MAS1 Proteins)) and a potential novel therapeutic target for MAS (show MAS1 Proteins).
Deficiency of plasminogen delays onset of autoimmune neuroinflammatory disease and protects from the development of paralysis.
Plasminogen may regulate DPP-4 (show DPP4 Proteins) activity and glucose metabolism.
Plasminogen-deficient mice frequently develop colon lesions and rectal prolapses.
manganese transport protein C (MntC) is an extracellular matrix- and plasminogen-binding protein
Plg from mouse plasma contains oxPtdPC adducts that are not affected by the action of Lp-PLA(2 (show Lp-PLA2 Proteins)), suggesting that linkage to Plg protects oxPtdPCs from metabolism during their transport in the plasma.
The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.
, lipoprotein, Lp(a)
, plasmin heavy chain A
, plasmin light chain B