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The protein levels of integrin alpha6 in lung adenocarcinoma tissues were significantly higher than those in adjacent tissues (p < 0.01), and were positively correlated with the grade and T stage of lung adenocarcinoma (p < 0.05). Patients with low integrin alpha6 protein levels had higher survival rates (p < 0.05).
Our findings suggest the significance of activating NFAT1/ITGA6 signaling in aggressive NPC, defining a novel critical signaling mechanism that drives NPC invasion and metastasis and providing a novel target for future personalized therapy.
Small interference ITGA6 gene targeting in the human thymic epithelium differentially regulates the expression of immunological synapse-related genes
MiR-127-3p inhibits cell growth and invasiveness by targeting ITGA6 in human osteosarcoma.
MiR-143-3p acts as an anti-oncogene by downregulating ITGA6/ASAP3 protein expression and could offer new insight into potential therapeutic targets for CRC.
RUNX1 regulates ITGA6 through a consensus RUNX1 binding motif in its promoter
This study found a significant association between Hepatitis B virus (HBV)and integrin A6, which may be responsible for early migration and invasion of hepatocellular carcinoma (HCC). Thus, integrin A6 is a predictive marker for tumor recurrence and invasiveness of HBV-driven HCC
alpha6-integrin is a matrix stiffness-regulated mechanosensitive molecule which confers an invasive fibroblast phenotype and mediates experimental lung fibrosis.
N-glycosylation controlled the EGFR complex formation with integrin alpha5beta1 or alpha6beta4
ITGA6 might be involved in a mechanism that underlies radiation resistance and that ITGA6 could be a potential target for therapies aimed at overcoming radiation resistance in breast cancer.
ITGA6 mRNA can be detected in stools of patients with colorectal cancers using droplet digital PCR.
In particular, methylation levels of ITGA4, RERG, and ZNF671 could distinguish Nasopharyngeal carcinoma (NPC) patients from non-cancer nasopharyngeal epithelium (NNE) subjects. We identified the DNA methylation rates of previously unidentified NPC candidate genes.
miR-92b/integrin alpha6/Akt axis controls the motility of esophageal squamous carcinoma cells.
High ITGA6 expression is associated with colorectal cancer.
During the past decades, many studies have provided evidence for a role of laminin-binding integrins in tumorigenesis, and both tumor-promoting and suppressive activities have been identified. (Review)
alpha6 beta4 integrin promotes resistance of cancer cells to ferroptosis.
Human pluripotent stem cells promote the expression of integrin alpha6beta1, and nuclear localization and inactivation of FAK to supports stem cell self-renewal.
Results provide evidence that alpha3 and alpha6 integrins have significantly different internalization kinetics and that coordination exists between them for internalization in prostate cancer cells.
IGF2 also requires integrin binding for signaling functions, and the IGF2 mutants that cannot bind to integrins act as antagonists of IGF1R.
By directly binding to the 3'UTRs of ITGA6 and ITGB1, we found miR-30e-5p to suppress mainly the adhesion of ITGA6 in CRC cells to laminin.Taken together, miR-30e-5p is a novel effector of P53-induced suppression of migration, invasion and metastasis
The study shows that ITGA3 and ITGA6 promote distinct functions and signaling by collecting duct cells on laminin substrata.
These data indicate that integrin alpha6beta4 and PMP22 cooperate to organize the internode and to allow proper propagation of the axonal signal along the axons.
miR-542-5p attenuates fibroblast activation by targeting ITGA6 in silica-induced pulmonary fibrosis.
alpha6 and beta1 integrins are induced in Schwann cells in the sciatic nerve after a crush injury, and the blocking of integrin activity by siRNA expression and by treatment with anti-integrin antibodies attenuates Schwann cell contact with cultured neurons and decreases neurite outgrowth. After nerve transection, the levels of alpha6 and beta1 integrins in the distal nerve stump are lower than corresponding nerve area...
CD24 and CD49f expressions of E14.5 mouse mammary anlagen cells define putative distribution of earlier embryonic mammary stem cell activities.
our data suggest that alpha6beta4 integrin upregulation is an inducible protective mechanism that stabilizes the blood-brain barrier during neuroinflammatory conditions.
he potential effect of Ntn-1 on angiogenesis is further verified by the mouse hindlimb ischemia model, where the pre-activation of hUCB-MSCs with Ntn-1 significantly improved vascular regeneration. These results demonstrate that Ntn-1 plays an important role in the tissue regeneration process of hUCB-MSC via the lipid raft-mediated Inalpha6beta4 signaling pathway.
RFX1 transcriptionally targets Itga6 in Sertoli cells, thereby, helping maintain the integrity of the basal lamina during testis cord development.
pericyte alpha6beta1-integrin regulates tumour blood vessels by both controlling PDGFRbeta and basement membrane architecture.
ITGA6 maintains structural integrity of the kidney collecting system.
Integrin alpha 6 Expression on Microglia Surface and Motility on Laminin Is Up-regulated upon Adenosine Diphosphate Stimulation.
Ahr ligand aminoflavone targets breast cancer cells with stem cell-like properties, at least in part by abolishing alpha6-integrin expression.
interaction of alpha6beta1 in embryonic stem cells (ECCs) with laminin-1 activates alpha6beta1/CD151 signaling which programs ESCs toward the endothelial cells lineage fate
Exome sequencing analysis between SM/J and A/J mice identified 4 genes (Itga6, Zak, Gpr155, and Mtx2) with nonsynonymous coding SNPs. These four genes might be candidate genes for type 2 diabetes caused by gene-gene interactions.
Immunohistological analysis of the tumors showed that Tie2-dependent a6 gene deletion was associated with reduced tumor vascularization and with reduced infiltration of proangiogenic Tie2-expressing macrophages
CD29 and CD49f have a critical role of in mediating cancer metastasis.
NLGN1 and alpha6 integrin preferentially colocalize in the mature retinal vessels, whereas NLGN1 deletion causes an aberrant VE-cadherin, laminin and alpha6 integrin distribution in vessels
alpha6 integrin is an essential upstream regulator of the IGF-1R survival pathway that regulates the activity level of caspase-3 for it to signal differentiation initiation of lens epithelial cells.
The expression of integrin-alpha6beta4 and laminin-5 (alpha3, beta3, gamma2) mRNAs was significantly higher on SA-treated c.p.Ti than on c.p.Ti and AO c.p.Ti disks after 3 days (P<0.05).
the secreted ligand Dkk3a binds to the membrane receptor Itgalpha6b, which increases the protein level of phosphorylated p38a and activates myf5 promoter activity of zebrafish embryos during myogenesis.
integrin alpha6beta4 was indeed involved in dairy cow mammary development.
This study showed a reduced expression of alpha-6 integrin in bovine spermatogonia separated by Percoll density gradient centrifugation.
formation of CD151-integrin complex was likely to be a prerequisite for CD151-induced angiogenesis and signaling pathways
The presence of these integrin subunits on the bovine oocyte vitelline membrane supports the hypothesis that sperm-oocyte interactions in the bovine are mediated by integrins.
Equine herpesvirus type 1 infection significantly decreased the expression of integrin alpha 6 in nasal mucosa epithelial cells.
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
CD49 antigen-like family member F
, integrin alpha-6
, integrin alpha6B
, integrin, alpha 6
, integrin alpha 6
, integrin alpha 6 subunit
, integrin alpha chain, alpha 6
, integrin alpha-6-like
, integrin, alpha 6b