BRCA2 Proteins

Protein Summary

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

Alternative names and synonyms associated with BRCA2

• BRCA2, DNA repair associated (BRCA2) antibody
• Breast cancer 2, early onset homolog (Brca2) antibody
• BRCA2, DNA repair associated (Brca2) antibody
• breast cancer 2, early onset (brca2) antibody
• breast cancer 2, early onset (LOC584780) antibody
• Show all gene names
• BRCA2, DNA repair associated (brca2) antibody
• breast cancer 2, early onset (Brca2) antibody

• 30169 antibody
• AI256696 antibody
• AW045498 antibody
• BcDNA:SD25109 antibody
• BRCA2 antibody
• Show all synonym aliases
• brcc2 antibody
• brovca2 antibody
• CG13583 antibody
• CG13584 antibody
• CG30169 antibody
• dmbrca2 antibody
• Dmel\\CG30169 antibody
• facd antibody
• fad antibody
• fad1 antibody
• fancb antibody
• FANCD antibody
• Fancd1 antibody
• GLM3 antibody
• PNCA2 antibody
• RAB163 antibody

Protein level used designations for BRCA2

BRCA1/BRCA2-containing complex, subunit 2 , breast and ovarian cancer susceptibility gene, early onset , breast cancer 2 tumor suppressor , breast cancer type 2 susceptibility protein , fanconi anemia group D1 protein , truncated breast and ovarian cancer susceptibility protein 2 , breast cancer 2, early onset homolog , CG30169-PA , Brca2-PA , breast cancer 2, mutation 1, University of Wisconsin-Madison , breast cancer susceptibility protein 2 , breast cancer type 2 susceptibility protein homolog , fanconi anemia group D1 protein homolog , breast and ovarian cancer susceptibility protein 2 , breast cancer 2, early onset , breast cancer type 2 susceptibility protein-like