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Full name:: Breast Cancer 2, Early Onset Proteins (BRCA2)

On www.antibodies-online.com are 6 Breast Cancer 2, Early Onset (BRCA2) Proteins from 3 different suppliers available. Additionally we are shipping BRCA2 Antibodies (88) and BRCA2 Kits (32) and many more products for this protein. A total of 130 BRCA2 products are currently listed.

Synonyms:: 30169, AI256696, AW045498, BcDNA:SD25109, BRCA2, brcc2, brovca2, CG13583, CG13584, CG30169, dmbrca2, Dmel\\CG30169, facd, fad, fad1, fancb, FANCD, Fancd1, GLM3, PNCA2, RAB163

list all proteins	Gene Name	GeneID	UniProt
	BRCA2	675	P51587
	BRCA2	360254
	BRCA2	12190	P97929
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Human Breast Cancer 2, Early Onset (BRCA2) interaction partners

Among BRCA mutation( BRCA1 or BRCA2) carriers, the mortality benefit of preventive mastectomy at age 25 is substantial, but the expected benefit declines rapidly with increasing age at surgery.
The present study demonstrates a clear protective effect of early first pregnancy on breast cancer risk in both BRCA1 and BRCA2 mutation carriers.
Overall, 5152 oncogenetic tests were reviewed in the present study, of which 4452 had no a priori known familial mutation. The majority of participants (68.6%) were genotyped because of personal history of cancer; 20.6% were tested because of family history of cancer, and details for the remaining 10.7% were missing. Overall, 256/4452 (5.8%) carriers were detected, 141 BRCA1 and 115 BRCA2 mutation carriers.
The present study aimed to clarify the clinicopathological features, including the level of p53 (show TP53 Proteins) protein expression and BRCA mutations, of primary fallopian tube cancer (PFTC) in Japanese women.
Germline mutations involving the Fanconi anemia (show PALB2 Proteins) pathway, such as BRCA2 are often implicated in Invasive Pancreatic Ductal Adenocarcinoma.
Authors found that BRCA1/2 germline mutations in China exhibit distinct characteristics compared to those in Western populations.
We show a strong association between Triple Negative Breast Cancer and mutations in BRCA1/2 genes and the poor outcome of these patients. The survival curve analysis showed that the presence of AKT1 (show AKT1 Proteins), TP53 (show TP53 Proteins), KDR (show KDR Proteins), KIT, BRCA1 and BRCA2 mutations is correlated with a poor prognosis.
Letter: BRCA2- and ATM (show ATM Proteins)-mutated prostate cancer sensitive to high dose testosterone.
The authors propose that BRCA2 antagonizes 53BP1 (show TP53BP1 Proteins), RIF1 (show INSL6 Proteins), and Artemis (show DCLRE1C Proteins)-dependent c-nonhomologous end-joining and alt-nonhomologous end-joining to prevent gross genomic instability in a RAD51 (show RAD51 Proteins)-independent manner.
region in the N terminus exhibits DNA binding activity and promotes RAD51 (show RAD51 Proteins)-mediated homologous recombination

Fruit Fly (Drosophila melanogaster) Breast Cancer 2, Early Onset (BRCA2) interaction partners

persistent meiotic DNA double-strand breaks might correspond to crossovers, which are mobilized to the nuclear envelope for their repair; Brca2-Pds5 complexes may be key mediators of this process.
A mutation in Cyp6d2, a cytochrome P450 gene, when combined with a brca2 mutation, resulted in synergistic hypersensitivity to camptothecin.
DNA repair by homologous recombination is dramatically decreased in CG30169 (brca2 homolog) mutants.

Zebrafish Breast Cancer 2, Early Onset (BRCA2) interaction partners

the data suggest for the first time that brca2/fancd1 is essential for vertebrate kidney ontogeny.
Carcinogenesis in zebrafish with combined mutations in tp53 (show TP53 Proteins) and brca2 typically requires biallelic mutation or loss of at least one of these genes.
The novel role of Brca2 in organizing the vertebrate egg nucleus may provide new insights into the origin of ovarian cancer
critical roles for brca2 in ovarian development and tumorigenesis in reproductive tissues

Mouse (Murine) Breast Cancer 2, Early Onset (BRCA2) interaction partners

Results suggest that the greater reliance on homology-directed repair (HDR (show GATA3 Proteins)) in the proliferating mammary gland, rather than a specific dependence on breast cancer 2 protein (BRCA2), may increase its susceptibility to tumorigenesis incurred by BRCA2 mutation.
The functional consequence of Parp1 (show PARP1 Proteins) heterozygosity on BRCA2 loss is demonstrated by a significant increase in tumorigenesis in Brca2 knockout mice.
Data indicate the importance of breast cancer 1 (show BRCA1 Proteins) protein (BRCA1 (show BRCA1 Proteins))/breast cancer 2 protein (BRCA2) function in cranial neural crest cells (CNCCs) during craniofacial skeletal formation.
we generated a Brca2 knock-in mouse model lacking exons 4-7 and demonstrated that these exons are dispensable for viability as well as tumor-free survival. This study provides the first in vivo evidence of the functional significance of a minor transcript of BRCA2 that can play a major role in the survival of humans who are homozygous for a clearly pathogenic mutation.
we describe a genetic approach to examine the functional significance of the interaction between BRCA2 and PALB2 (show PALB2 Proteins) by generating a knock-in mouse model of Brca2 carrying a single amino acid change (Gly25Arg, Brca2G25R) that disrupts this interaction. In addition, we have combined Brca2G25R homozygosity as well as hemizygosity with Palb2 (show PALB2 Proteins) and Trp53 (show TP53 Proteins) heterozygosity .
Merit40 mutation exacerbated ICL-induced chromosome instability in the context of concomitant Brca2 deficiency but not in conjunction with Fancd2 mutation.
Heterozygous and homozygous Brca2 mutation may lead to dysfunction in T cell populations.
BRCA2 exon 27 domain maintains chromosomal integrity at both stalled and collapsed replication forks consistent with involvement in both replication fork maintenance and double strand break repair.
we use a genetically engineered mouse model of BRCA2-associated hereditary breast cancer to study drug resistance to several types of chemotherapy and PARP (show PARP1 Proteins) inhibition.
BRCA2-mediated sequestration of nuclear RAD51 (show RAD51 Proteins) serves to prevent inappropriate DNA interactions.

BRCA2 Protein Profile

Protein Summary

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

Alternative names and synonyms associated with BRCA2

BRCA2, DNA repair associated (BRCA2)
Breast cancer 2, early onset homolog (Brca2)
BRCA2, DNA repair associated (Brca2)
breast cancer 2, early onset (brca2)
breast cancer 2, early onset (LOC584780)
BRCA2, DNA repair associated (brca2)
breast cancer 2, early onset (Brca2)

30169 protein
AI256696 protein
AW045498 protein
BcDNA:SD25109 protein
BRCA2 protein
brcc2 protein
brovca2 protein
CG13583 protein
CG13584 protein
CG30169 protein
dmbrca2 protein
Dmel\\CG30169 protein
facd protein
fad protein
fad1 protein
fancb protein
FANCD protein
Fancd1 protein
GLM3 protein
PNCA2 protein
RAB163 protein

Protein level used designations for BRCA2

BRCA1/BRCA2-containing complex, subunit 2 , breast and ovarian cancer susceptibility gene, early onset , breast cancer 2 tumor suppressor , breast cancer type 2 susceptibility protein , fanconi anemia group D1 protein , truncated breast and ovarian cancer susceptibility protein 2 , breast cancer 2, early onset homolog , CG30169-PA , Brca2-PA , breast cancer 2, mutation 1, University of Wisconsin-Madison , breast cancer susceptibility protein 2 , breast cancer type 2 susceptibility protein homolog , fanconi anemia group D1 protein homolog , breast and ovarian cancer susceptibility protein 2 , breast cancer 2, early onset , breast cancer type 2 susceptibility protein-like

GENE ID	SPECIES
675	Homo sapiens
37916	Drosophila melanogaster
360254	Rattus norvegicus
374139	Gallus gallus
493878	Felis catus
566758	Danio rerio
584780	Strongylocentrotus purpuratus
721981	Macaca mulatta
100397509	Callithrix jacchus
452526	Pan troglodytes
474180	Canis lupus familiaris
100038818	Xenopus (Silurana) tropicalis
100601625	Nomascus leucogenys
12190	Mus musculus
100064578	Equus caballus
507069	Bos taurus

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