Browse our anti-CETN2 (CETN2) Antibodies

Zebrafish Centrin, EF-Hand Protein, 2 (CETN2) interaction partners

1. Centrin2 depletion causes cilia-related disorders in zebrafish.

Mouse (Murine) Centrin, EF-Hand Protein, 2 (CETN2) interaction partners

1. Removal of CETN2 and CETN3 activity from the lumen of the connecting cilium (CC) destabilized the photoreceptor axoneme and reduced the CC length as early as postnatal day 22 (P22).

2. This study demonistrated that CETN2 regulates protein trafficking of olfactory cilia and participates in specifying planar polarity of ependymal cilia.

3. Binding of Cen2 and Cen4 to Gbetagamma of non-visual G-proteins regulates G-proteins involved in centrosome and basal body functions

Human Centrin, EF-Hand Protein, 2 (CETN2) interaction partners

1. Multidisciplinary approach showed that HsPrp40Ap interacts with centrin in vitro, supporting a coupled functional role for these proteins in pre-mRNA splicing.

2. Cetn3 inhibits Mps1 autophosphorylation at Thr-676, a known site of T-loop autoactivation, and interferes with Mps1-dependent phosphorylation of Cetn2. The cellular overexpression of Cetn3 attenuates the incorporation of Cetn2 into centrioles and centrosome reduplication, whereas depletion of Cetn3 generates extra centrioles.

3. Centrin2 regulates primary ciliogenesis through controlling CP110 levels.

4. co-depletion of centrin 2 and PCID2 leads to blocking rather than delaying nuclear protein export, indicating the dominance of the centrin 2 phenotype.

5. Data indicate that overexpression of the centrin interactor POC5 leads to the assembly of linear, centrin-dependent structures.

6. CDC25B, through activation of a centrosomal pool of CDK2, stabilises the local pool of Mps1 which in turn regulates the level of centrin 2 at the centrosome.

7. Cen2 influences the binding of RPA and XPA with damaged DNA.

8. xeroderma pigmentosum complementation group C expression correlates with a decreased amount of CENTRIN 2 transcript and protein

9. The stability of centrin is regulated in part by Aurora A.

10. Mps1-dependent phosphorylation of Cetn2 stimulates the canonical centriole assembly pathway.

11. CDC25B forms a close association with Ctn-2 proteins at the centrosome.

12. oxidative radicals induce high proportions of irreversible damages (polymerisation) centrin 2 is highly sensitive to ionising radiation.

13. required for centriole duplication in mammalian cells

14. The solution structure of the long C-terminal fragment of centrin 2 exhibits an open two EF-hand structure, similar to the conformation of related Ca(2+)-saturated regulatory domains.

15. structural characterization of the complex formed by the C-terminal domain of Cen2 with a peptide of xeroderma pigmentosum group C protein

16. Results describe the self-assembly properties of purified human centrin-2 in vitro.

17. Centrin 2 stimulates nucleotide excision repair by interacting with XPC.

18. an 18-residue peptide, from the N-terminal unstructured fragment, has a significant affinity for the isolated C-terminal domain, suggesting an active role in the self-assembly of centrin molecules.

19. the crystal structure of calcium-loaded full-length centrin-2 complexed with a xeroderma pigmentosum group C peptide; a novel binding motif for centrin

20. A complex formed by a Ca2+-bound human centrin 2 with a 17-mer peptide derived from the XPC sequence was crystallized.