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anti-Human MCM3 Antibodies:
anti-Rat (Rattus) MCM3 Antibodies:
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Human Polyclonal MCM3 Primary Antibody for IHC, IHC (p) - ABIN151755
Kim, Kee, Gurtan, DAndrea: Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24. in Blood 2008
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Human Polyclonal MCM3 Primary Antibody for ICC, IF - ABIN4333200
Nodin, Fridberg, Jonsson, Bergman, Uhlén, Jirström: High MCM3 expression is an independent biomarker of poor prognosis and correlates with reduced RBM3 expression in a prospective cohort of malignant melanoma. in Diagnostic pathology 2012
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Study characterize the interaction of Keap1, a central antioxidant response regulator in Metazoa, with the replicative helicase subunit protein MCM3. Analysis suggests that structural determinants of the interaction of Keap1 with its critical downstream target - Nrf2 master transactivator of oxidative stress response genes - may have evolved in evolution to mimic the conserved helix-2-insert motif of MCM3.
Data report that MCM3 is a novel target of Pin1 through directly interacting with Pin1 WW domain. Proline-directed phosphorylation of MCM3 at S112 and T722 are crucial for the interaction with Pin1. MCM3 as a subunit of the MCM2-7 heterocomplex is part of the pre-replication complex responsible for replication licensing and is implicated in the formation of the replicative helicase during the replication progression.
Ki-67, MCM-3, and MCM-7, but not MCM-5 are reliable proliferative and diagnostic markers in discerning benign and malignant adrenocortical tumors.
this study shows that MCM3 is a novel proliferation marker in oral squamous cell carcinoma
High MCM3 expression is associated with bone metastasis and advanced human prostate cancer.
the decreased growth of osteosarcoma cells by MCM2 or MCM3 knockdown was reversed by DHX9 overexpression, indicating that MCM2 and MCM3 activity was DHX9-dependent.
reveal the Minichromosome Maintenance Complex to be a critical and directly regulated node within the miR-183 signaling network in MYCN-amplified neuroblastoma cells. Randomly selected MCMs 3 and 5 were experimentally confirmed as direct targets of miR-183.
The results of our preliminary study emphasize the need for future research on MCM-3 as a sensitive proliferation marker, providing an alternative to Ki-67, in cases of various major salivary gland epithelial tumors in children and adolescents.
These data establish new functions for KEAP1 within the nucleus and identify MCM3 as a novel substrate of the KEAP1-CUL3-RBX1 E3 ligase.
The aim of this study is to analyze the immunoexpression of Ki67, p53, MCM3 and PCNA markers in epithelial remnants of dental follicles of impacted teeth and to identify a possible correlation between the immunoexpression of these markers in dentigerous cysts and keratocystic odontogenic tumors.
High MCM-3 expression correlated with Cutaneous T-cell Lymphomas.
normal DNA replication and replication checkpoint activation is regulated through the novel phosphorylation of MCM3 by Chk1
Results show that in Glioma patients, MCM 2, MCM3 and MCM7 mRNA are up-regulated and correlated with poor outcome.
Of the total, the deregulation of several genes (CDK1, CDK2, CDK4, MCM2, MCM3, MCM4, EIF3a and RPN2) were potentially associated with disease development and progression.
Relatively lower MCM3 protein expression in follicular variant of papillary thyroid carcinoma comparing to classical type could be due to a different tumorigenic pathway favored in this type of tissue.
Expression of KB cell MCM3 was not affected by doxorubicin.
present study aimed to investigate the relationship between expression of minichromosome maintenance proteins (MCM-3, MCM-7), metallothioneins (MT-I/II, MT-III), and Ki-67 in 103 ovarian cancer cases, mostly of the serous histological type
Mcm2-7 loads onto origins during initiation as a double hexamer, yet does not act as a double-stranded DNA pump during elongation.
High MCM3 expression is associated with mucoepidermoid carcinomas and adenoid cystic carcinomas in salivary gland tumors.
The MCM3-C could promote the dissociation of Cdc6 by just inhibiting the re-binding of Cdc6 or actually accelerate its dissociation.
Mcm3-deficient erythroblasts display aberrant DNA replication patterns and fail to complete maturation, causing lethal anemia.
interaction with GANP DNA-primase is associated with a novel phosphatase component G5PR
Depletion of Orc2 and Mcm3 by siRNA leads to an inhibition of cell proliferation, an altered cell cycle distribution as well as to multinucleated cells with insufficiently organised microtubules.
analysis of carboxyl-terminal MCM3 phosphorylation sites and their motifs
These data reveal that CDK-dependent MCM3 phosphorylation contributes to the regulated formation of the MCM2-7 complex.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.
, minichromosome maintenance 3
, minichromosome maintenance-PCR2
, MCM3 minichromosome maintenance deficient 3
, zygotic minichromosome maintenance protein 3
, DNA replication licensing factor MCM3
, DNA polymerase alpha holoenzyme-associated protein P1
, DNA replication factor MCM3
, RLF subunit beta
, cervical cancer proto-oncogene 5
, hRlf beta subunit
, minichromosome maintenance deficient 3
, replication licensing factor, beta subunit
, P1 homolog
, XRLF subunit beta
, maternal DNA replication licensing factor mcm3
, maternal minichromosome maintenance protein 3
, mini chromosome maintenance deficient