anti-PMS2 Antibodies

118 PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) Antibodies from 27 manufacturers are available on www.antibodies-online.com.

Data Quality
  • 1
  • 46
Type
  • 118
    Primary antibodies
Antigen
  • 118
Reactivity
  • 118
  • 25
  • 20
  • 2
  • 2
Application
  • 84
  • 55
  • 40
  • 23
  • 19
Host
  • 87
  • 30
  • 1
Clonality
  • 79
  • 39
Clone
  • 8
  • 3
  • 3
  • 2
  • 2
Binding Specificity
  • 11
  • 8
  • 5
  • 4
  • 4
Conjugate
  • 100
  • 4
  • 2
  • 2
  • 2
Isotype
  • 52
  • 13
  • 4
  • 4
  • 3
Format
  • 68
  • 3
Suggested next Filters
118 Products
ReactivityHuman
Application ELISA, FACS, ICC, IHC, WB
Order details Cat. No. ABIN5542596
$430.10
0.1 mg
Plus shipping costs $45.00
Delivery in 3 to 4 Business Days
ReactivityHuman
Order details Cat. No. ABIN5914774
$464.30
100 μg
Plus shipping costs $45.00
Delivery in 11 to 16 Business Days
ReactivityHuman
Application IP, ELISA, WB
Order details Cat. No. ABIN129513
$613.50
100 μg
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 5 to 7 Business Days
ReactivityHuman
Application IF, IP, WB
Order details Cat. No. ABIN6292715
$309.73
50 μL
Plus shipping costs $45.00
Delivery in 11 to 13 Business Days
ReactivityHuman
Application IF, IP, WB
Order details Cat. No. ABIN6568121
$438.90
Plus shipping costs $45.00
Delivery in 12 to 14 Business Days
ReactivityHuman
Application IF, WB
Order details Cat. No. ABIN518994
$440.00
50 μL
Plus shipping costs $45.00
Delivery in 11 to 12 Business Days
ReactivityHuman, Mouse (Murine), Rat (Rattus)
Application IHC, ELISA, WB
Order details Cat. No. ABIN2435222
$493.90
Plus shipping costs $45.00
Delivery in 12 to 14 Business Days
ReactivityHuman
Application ELISA, IF, IHC, WB
Order details Cat. No. ABIN3186513
$369.83
Plus shipping costs $45.00
Delivery in 11 to 13 Business Days
ReactivityHuman
Application IF, WB
Order details Cat. No. ABIN6145829
$393.25
Plus shipping costs $45.00
Delivery in 13 to 14 Business Days
ReactivityHuman
Application WB
Order details Cat. No. ABIN634259
$517.86
50 μg
Plus shipping costs $45.00
Delivery in 9 to 11 Business Days
ReactivityHuman
Application IHC (p)
Order details Cat. No. ABIN1027499
$1,047.86
7 mL
Plus shipping costs $45.00
Delivery in 15 to 18 Business Days
ReactivityHuman
Application IHC (p)
Order details Cat. No. ABIN1027500
$1,239.04
1 mL
Plus shipping costs $45.00
Delivery in 15 to 18 Business Days
ReactivityHuman
Application IF, IHC, WB
Order details Cat. No. ABIN2564595
$368.95
100 μL
Plus shipping costs $45.00
Delivery in 11 to 13 Business Days
ReactivityHuman
Application ELISA, ICC, IF, WB
Order details Cat. No. ABIN6258635
$390.77
Plus shipping costs $45.00
Delivery in 11 to 12 Business Days
ReactivityHuman, Mouse (Murine)
Application ELISA, ICC, IF, WB
Order details Cat. No. ABIN6258634
$390.77
Plus shipping costs $45.00
Delivery in 11 to 12 Business Days
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PMS2 Antigen Profile

Protein Summary

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2- MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753}.

Alternative names and synonyms associated with PMS2

  • PMS1 homolog 2, mismatch repair system component (PMS2) antibody
  • PMS1 homolog 2, mismatch repair system component (Pms2) antibody
  • PMS1 homolog2, mismatch repair system component (Pms2) antibody
  • mismatch repair endonuclease PMS2 (LOC463257) antibody
  • mismatch repair endonuclease PMS2 (LOC107984056) antibody
  • AW555130 antibody
  • HNPCC4 antibody
  • PMS2CL antibody
  • Pmsl2 antibody

Protein level used designations for PMS2

DNA mismatch repair protein PMS2 , H_DJ0042M02.9 , PMS1 protein homolog 2 , mismatch repair endonuclease PMS2 , PMS2 postmeiotic segregation increased 2

GENE ID SPECIES
5395 Homo sapiens
288479 Rattus norvegicus
18861 Mus musculus
463257 Pan troglodytes
479751 Canis lupus familiaris
100514342 Sus scrofa
527039 Bos taurus
101752182 Gallus gallus
100726203 Cavia porcellus
107984056 Homo sapiens
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