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Rs1800544 polymorphism is associated with bone turnover markers level in Chinese elderly individuals with osteoporotic fractures, indicating the involvement of genetic variation of a2A-AR gene in bone metabolism.
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ADRA2A genetic variation contributes independently to the risk of GDM in Caucasian women.
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Results describe association of ADRA2A rs553668 with type 2 diabetes in a Mexican population.
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Significant group*genotype interactions were found for 3 ADRA2A variants revealing steeper delay discounting (DD) in cocaine users (but not controls) carrying the G-allele of rs1800544, the T-allele of rs521674 and the C-allele of rs602618. High ADRA2A mRNA expression levels were significantly associated with a reduced tendency to choose smaller more immediate rewards in cocaine users.
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The summary of this study, none of the examined variants reached the threshold for statistical significance after correction for multiple testing. The SNP rs1800544 in ADRA2A, revealed nominally significant association, but the direction of effect was the opposite to that reported in previous studies conducted in children and adolescents.
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The results of this study suggested that ADRA2A rs3750625 contributes to poststress musculoskeletal pain severity by modulating miR-34a regulation
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This study reveled that ADA2A are up regulate in peripheral blood mononuclear cells in patient with multiple sclerosis.
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Results show that ADRA2A genetic variants are associated with blood glucose and stress-induced hyperglycemia after acute myocardial infarction in Caucasians.
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These findings suggest that Gi1 interacts only with active GPCRs and that the well known high speed of GPCR signal transduction does not require preassembly between G proteins and GPCRs.
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ADRA2A Germline Gene Polymorphism is Associated to the Severity, but not to the Risk, of Breast Cancer.
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Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2
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The ADRA2A C-1291G and COMT Val158Met genotypes and sex interact in predicting detection and perception of emotional valence in facial expressions
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ADRA2a is associated with heart rate recovery after exercise.
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Study is in line with previous reports of an association between ADRA2A gene variants and general reaction time variability during response selection tasks
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Genetic association of ADRA2A single nucleotide polymorphism with metabolic syndrome and high level insulin among the Tatars
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The rs10885122G>T polymorphism of the ADRA2A gene was not associated with type 2 diabetes mellitus in Euro-Brazilians, and carriers of the T allele had lower body weight in the presence of type 2 diabetes mellitus.
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Common polymorphisms in the ADRA2A gene are not associated with orthostatic hypotension risk in Chinese.
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The alpha2a AR expression in breast cancer was associated with Her-2 status (P = 0.048) and a marginal significance was observed between alpha2a AR expression and estrogen receptor (P = 0.061).
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Study found evidence that DNA variation in the ADRA2A gene may be causally related to ADHD-like behaviors, in part through its influence on intra-individual variability
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The accuracy of prediction for breast cancer relapse based solely on the expression of ADRA2A gene is high.
