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Data suggest that ZIP, USP39, Prp24/p100/SART3, and Prp43 associate to form complex instrumental in spliceosome assembly; ZIP regulates pre-mRNA splicing of USP39 independent of RNA binding; stable 35S tri-snRNP particles are enriched in Cajal body. (USP39 = ubiquitin specific peptidase 39; SART3 = squamous cell carcinoma antigen recognised by T cells 3; Prp43 = RNA helicase Prp43)
sZIP, an alternative splice variant of ZIP, antagonizes transcription repression and growth inhibition by ZIP in liver neoplasms.
Transcription repressor that specifically binds the 5'- GGAGA-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration (By similarity).
zinc finger, CCCH-type with G patch domain
, zinc finger CCCH-type with G patch domain-containing protein
, zinc finger CCCH-type with G patch domain-containing protein-like
, g patch domain-containing protein 6
, zinc finger CCCH domain-containing protein 9
, zinc finger and G patch domain-containing protein