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involvement of ZNF281 in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms
High ZNF281 expression is associated with colon and breast cancer.
By characterizing Zfp281 mutant phenotypes and identifying Zfp281 gene targets and protein partners in developing embryos and cultured pluripotent stem cells, the authors establish critical roles for Zfp281 in activating components of the Nodal signaling pathway and lineage-specific genes.
an important role of Zfp281 in restricting the expression of F type of young L1s in mouse embryonic stem cells.
AFF3 is associated with the Kruppel-like zinc finger protein ZFP281 in embryonic stem (ES) cells. ZFP281 recruits AFF3 to the Meg3 enhancer within the imprinted Dlk1-Dio3 locus, thus regulating the allele-specific expression of the Meg3 polycistron.
Zfp281 interacts with Tet1, but not Tet2, and its direct transcriptional target, miR-302/367, to negatively regulate Tet2 expression to establish and maintain primed pluripotency.
Zpf281 mediates Nanog autorepression through recruitment of the NuRD complex and hibits somatic cell reprogramming.
Data demonstrated that Zfp281 is required for Nanog (show NANOG Proteins) binding to its own promoter, suggesting that Nanog (show NANOG Proteins)-associated repressive complex(es) involving Zfp281 may fine-tune Nanog (show NANOG Proteins) expression for pluripotency of ESCs (show NR2E3 Proteins).
Zfp281 plays bifunctional roles in regulating gene expression within the network.
Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin and ornithine decarboxylase. Binds to the G-rich box in the enhancer region of these genes.
zinc finger protein 281
, GC-box-binding zinc finger protein 1
, ZNP-99 transcription factor
, transcription factor ZBP-99
, zinc finger DNA-binding protein 99