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Studied effect of recombinant human fibroblast growth factor 20 (rhFGF20) on cultured mouse vibrissal follicles; found rhFGF20 significantly induced growth of the follicles in vitro, stimulated proliferation of hair matrix cells, and activated Wnt signal pathway.
This study confirmed that the A allele of rs591323 in FGF20 reduces the risk of developing sporadic PD (P = 0.013). Additionally, subjects with the AA + AG genotype have a reduced risk compared to individuals with the GG genotype (P = 0.024).
the FGF20 gene might not play a dominating role in the genetic predisposition to essential tremor in Chinese Han population.
Meta-analysis indicated that the rs12720208 polymorphism may be associated with the Parkinson's disease susceptibility in Caucasians
This study suggested that there is no sufficient evidence to support the association between FGF20 rs12720208 polymorphism and Parkinson's disease risk.
The results of this study indicated that rs12720208 may contribute to the risk of PD in Iranian population.
Meta-analysis suggests that FGF20 rs1721100 C/G polymorphism is associated with sporadic sporadic Parkinson's diseases in Asians
The meta-analysis showed an association between FGF20 gene rs1721100 polymorphism and risk of Parkinson's disease under a recessive model.
The results showed no significant differences in the presence of rs1721100 or rs12720208 in the FGF20 gene between Parkinson's disease patients and controls.
The results have not shown any effect of rs12720208 in the FGF20 gene on the risk of Parkinson's disease in patients residing in Russia
This study revealed that the rs1721100(C/G) polymorphism is a risk factor for PD in Han Chinese population, while rs12720208(C/T) polymorphism is not significantly associated with Parkinson's disease.
The data suggested that Fgf9/20 and Bmp7 organize the nephron progenitor niche and highlight the essential role of FGF20 in human kidney development. FGF signaling likely regulates multiple important steps in the stem cell niche.
The common FGF20 rs12720208 SNP was not associated with the risk for Parkinson's disease (PD) in our population. In addition, we did not find nucleotide changes in miR-433 (that binds to the 3' UTR FGF20 mRNA) among our PD patients.
The associations described, from mRNA expression to brain morphology to cognition and an interaction with aging, confirm a role of FGF20 in human brain structure and function during development and aging.
Fibroblast growth factor 20 polymorphisms and haplotypes is associated with the risk of Parkinson disease
Data show that FGF20 and DKK1 appear to be direct targets for beta-catenin/TCF transcriptional regulation via LEF/TCF-binding sites, and are expressed early in Xenopus embryogenesis under the control of the Wnt signaling pathway
results suggest that the FGF20 gene is a susceptibility gene for Parkinson's disease in the Japanese population
Variants in FGF20 and MAOB show evidence of statistical interactions and potential patterns of biological interaction contributing to Parkinson disease risk.
Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein.
FGF20 is associated with Parkinson's disease synergistically with SNCA.
Data show that Fibroblast Growth Factors (FGF) 9 and 20 regulate the number of cochlear progenitors.
fibroblast growth factor 20 (Fgf20) is expressed in hair placodes and is induced by and functions downstream from epithelial ectodysplasin (Eda)/Edar and Wnt/beta-Catenin signaling to initiate formation of the underlying dermal condensation
We hypothesized that Fgf20 plays a role in specification, amplification, or maintenance of Sox2 expression in prosensory progenitors of the developing mammalian cochlea.
Fgf20 is a major downstream effector of ectodysplasin and affects ectodysplasin-regulated characteristics of tooth morphogenesis, including the number, size and shape of teeth.
The data suggested that, at a minimum, Fgf9/20 and Bmp7 organize the nephron progenitor niche. FGF signaling likely regulates multiple important steps in the niche, including survival, proliferation, and competence.
Data indicate that the viability and hearing loss in Fgf20 knockout mice suggest that FGF20 may also be a deafness-associated gene in humans.
expression of FGF20 in calvarial and limb development
Fgf20 is expressed at the right time and place to mediate sensory cell specification and is the likely activator/ligand of fibroblast growth factor (FGF) receptor 1 during cochlear development.
The evidence presented here indicates that fgf20a is important for normal mid-facial and calvarial growth and homeostasis in zebrafish, and that a key aspect of its influence on skull morphogenesis is the regulation of osteoblast and osteoclast activity during craniofacial remodeling.
Data indicate that fgf20a, fgf24, FGF receptor fgfr1 are expressed in normal and regenerating barbel tissue.
Hdac1 is required for expression of erm and fgf20a in rhombomeres; Hdac1-dependent expression of these two genes is attenuated in rhombomere boundary regions by Notch signalling activity
fgf20a has a regeneration-specific requirement, initiating fin regeneration, and controlling blastema formation
fgf20a is expressed in the intact fin and is required for homeostasis.
The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility.
fibroblast growth factor 20
, LOW QUALITY PROTEIN: fibroblast growth factor 20
, fibroblast growth factor 20 L homeolog
, fibroblast growth factor 20 S homeolog
, devoid of blastema