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anti-Human CNR1 Antibodies:
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Human Polyclonal CNR1 Primary Antibody for WB - ABIN1881140
Van Laere, Casteels, Dhollander, Goffin, Grachev, Bormans, Vandenberghe: Widespread decrease of type 1 cannabinoid receptor availability in Huntington disease in vivo. in Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010
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Human Polyclonal CNR1 Primary Antibody for ELISA, WB - ABIN250833
Porcella, Maxia, Gessa, Pani: The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein. in The European journal of neuroscience 2000
Show all 3 Pubmed References
Human Polyclonal CNR1 Primary Antibody for ICC, IHC (fro) - ABIN152711
Mulhern, Madson, Danford, Ikesugi, Kador, Shinohara: The unfolded protein response in lens epithelial cells from galactosemic rat lenses. in Investigative ophthalmology & visual science 2006
This study of single-nucleotide polymorphisms in the cannabinoid receptor gene CNR1 showed that C carriers at rs806374 may be at specific risk for increased odds of cannabis use during the transition out of high school (around age 18).
results suggest that palmitoylation of the CB1 receptor finely tunes its interaction with G proteins and serves as a targeting signal for its functional regulation
we have associated cannabinoid 1 (CB1) receptor genetic variation rs2180619 (AA, AG, GG), which is located in a potential CNR1 regulatory sequence, with performance in working memory. no differences were found among genotypes while performing each working memory (WM) task. However, the cost of the level of complexity in N-back paradigm was double for GG subjects than for AA subjects.
phenotypes associated with rare CNR1 variants are reminiscent of those implicated in the theory of clinical endocannabinoid deficiency syndrome. The severe phenotypes associated with rare DAGLA (show DAGLA Antibodies) variants underscore the critical role of rapid 2-AG synthesis and the endocannabinoid system in regulating neurological function and development
two agonist-bound crystal structures of human CB1 in complex with a tetrahydrocannabinol (AM11542) and a hexahydrocannabinol (AM841) at 2.80 A and 2.95 A resolution, respectively
that a genetically modulated balancing of signaling within the CB1-COX-2 (show COX2 Antibodies) pathway may reflect on more or less efficient patterns of prefrontal activity during working memory
In cotransfected HEK (show EPHA3 Antibodies)-293 cells, SSTR5 (show SSTR5 Antibodies) and CB1R existed in a constitutive heteromeric complex under basal condition, which was disrupted upon agonist treatments. Furthermore, concurrent receptor activation led to preferential formation of SSTR5 (show SSTR5 Antibodies) homodimer and dissociation of CB1R homodimer.
CB1R availability was inversely associated with BMI in homeostatic brain regions such as the hypothalamus and brainstem areas in both patients with food intake disorders(FID) and healthy subjects. However, in FID patients, CB1R availability was also negatively correlated with BMI throughout the mesolimbic reward system.
hepatic expression of CB1 and CB2 (show CNR2 Antibodies) plays an important role during the progression of fibrosis induced by chronic hepatitis B
propose here a possible unifying theory of CB1 receptor functions.
Data show that systemic, hippocampal, and peripheral blockade of cannabinoid type-1 (CB1) receptors abolished the stress-induced memory impairment.
this study shows that genetic or pharmacological depletion of cannabinoid CB1 receptor protects against dopaminergic neurotoxicity induced by methamphetamine in mice
CB1R knockout mice demonstrated increased injury following stroke, indicating that activation of the CB1R was neuroprotective, later studies of selective antagonists of the CB1R also demonstrated a protective effect
Findings demonstrate a critical distinction of the altered balance of glutamate (show GRIN1 Antibodies)-type 1 cannabinoid receptor and GABA-type 1 cannabinoid receptor activity that could participate in the vulnerability to cocaine abuse and addiction.
renal proximal tubule cell CB1R contributes to the pathogenesis of obesity-induced renal lipotoxicity and nephropathy by regulating the liver kinase B1 (show STK11 Antibodies)/AMP-activated protein kinase (show PRKAA2 Antibodies) signaling pathway
a protein involved in macroautophagy/autophagy (a conserved lysosomal degradation pathway), BECN2 (beclin 2), mediates cannabinoid tolerance by preventing CNR1 recycling and resensitization after prolonged agonist exposure, and deletion of Becn2 rescues CNR1 activity in mouse brain and conveys resistance to analgesic tolerance to chronic cannabinoids
N-arachidonoyl ethanolamine and 2-arachidonoyl glycerol hydrolyzing enzymes, FAAH (show FAAH Antibodies) and MAGL (show MGLL Antibodies), and the CB1 receptor link the endocannabinoid system to broader lipid signaling networks in contrasting ways, potentially altering neurotransmission and behavior independently of cannabinoid receptor signaling.
Given overlapping and complementary functions of CB1 and CB2 (show CNR2 Antibodies) receptors, we queried whether double-knockout mice would show an exacerbated neurological phenotype
this study shows that the expression of CB1 receptor in B-lymphocytes is differentially regulated during pregnancy
Loss of adipocyte CB1 affects energy balance by promoting a profound remodeling in depot-specific adipocyte functions.
genetic or chemical inhibition of cannabinoid receptor (Cnr (show PCDHA1 Antibodies)) activity disrupts liver development and metabolic function in zebrafish.
CB1 function is required in the early embryo for axonal growth and fasciculation.
The endocannabinoid system in renal cells: regulation of sodium transport by CB1 receptors through distinct cell signaling pathways
Anandamide, through CB1 and TRPV1 (show TRPV1 Antibodies) activation, is involved in sperm release from the oviductal reservoir.
A novel mechanism has been identified underlying a CB1R-mediated increase in retinal ganglion cell intrinsic excitability acting through AMPK (show PRKAA2 Antibodies)-dependent inhibition of NKCC1 (show SLC12A2 Antibodies) activity.
CB1 functionality increased with development at both central and peripheral level.
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.
cannabinoid receptor 1
, central cannabinoid receptor
, brain-type cannabinoid receptor
, striatal cannabinoid receptor type 1 protein
, CB1 cannabinoid receptor
, cannabinoid receptor CB-1
, cannabinoid receptor 1 (brain)
, cannabinoid receptor 1-like
, cannabinoid 1 receptor
, cannabinoid receptor 1/CB1