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anti-Human CNR1 Antibodies:
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Human Polyclonal CNR1 Primary Antibody for WB - ABIN1881140
Van Laere, Casteels, Dhollander, Goffin, Grachev, Bormans, Vandenberghe: Widespread decrease of type 1 cannabinoid receptor availability in Huntington disease in vivo. in Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010
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Human Polyclonal CNR1 Primary Antibody for ELISA, WB - ABIN250833
Porcella, Maxia, Gessa, Pani: The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein. in The European journal of neuroscience 2000
Show all 3 Pubmed References
Human Polyclonal CNR1 Primary Antibody for ICC, IHC (fro) - ABIN152711
Mulhern, Madson, Danford, Ikesugi, Kador, Shinohara: The unfolded protein response in lens epithelial cells from galactosemic rat lenses. in Investigative ophthalmology & visual science 2006
Dog (Canine) Polyclonal CNR1 Primary Antibody for ELISA, WB - ABIN547528
Ledent, Valverde, Cossu, Petitet, Aubert, Beslot, Böhme, Imperato, Pedrazzini, Roques, Vassart, Fratta, Parmentier: Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. in Science (New York, N.Y.) 1999
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cannabis consumption regulates the formation of CB1R-5HT2AR heteromers, and may have a key role in cognitive processing.
findings may open a new conceptual framework to understand the role of coordinated adenosine-endocannabinoid signaling in the indirect striatal pathway, which may be relevant in motor function and neurodegenerative diseases.
Study showed that relative to females, the cannabinoid CB1 receptor availability was on average 41% higher in males with a regionally specific effect larger in the posterior cingulate and retrosplenial cortices.
We focused on rs2180619 (A > G) polymorphism. We found, genotype-related differences in the impact of affective information in working memory(WM). carriers of at least one major allele focused on positive information in WM representations to a greater extent than negative and neutral information. carriers of two minor allele (GG) did not show a stronger preference for positive items, but a more general enhancement effect.
This study uncovers a PAX7-CB1 cross talk potentially exacerbating Duchenne muscular dystrophy.
The cannabinoid receptor 1 (CNR1) was identified as a direct target gene of miR1273g3pand knockdown of CNR1 restored the phenotypes of LoVo cells transfected with miR1273g3p inhibitor.
The Arg82 and Cys126 of CRIP1b are involved in the majority of hydrogen bond interactions with the CB1 receptor and are possible key residues required for interactions between the CB1 receptor and CRIP1b
The CB1 pathway is involved in the pathogenesis of shoulder stiffness. It may be a promising target for the treatment of rotator cuff lesions with shoulder stiffness.
CB1 receptors are among the most abundant G protein-coupled receptors in the brain that impact on several processes, including fear coping, anxiety, stress, learning, and memory. (Review)
CB1 receptor (CB1b) is highly expressed in pancreatic beta-cells and hepatocytes but not in the brain.
All of the epithelial layers in 94, 78, 96, 73 and 80% of pterygia cases, exhibited CB1, CB2, TRPV1, TRPV2 and TRPV3 cytoplasmic immunoreactivity, respectively.
observed selective alterations of DNA methylation at the promoter of CNR1, the gene coding for the type-1 cannabinoid receptor, in schizophrenic patients with no changes in bipolar or major depressive disorder. In an animal model prefrontal cortex found a significant increase in CNR1 expression and a consistent reduction in DNA methylation at specific CpG sites of gene promoter.
This study of single-nucleotide polymorphisms in the cannabinoid receptor gene CNR1 showed that C carriers at rs806374 may be at specific risk for increased odds of cannabis use during the transition out of high school (around age 18).
results suggest that palmitoylation of the CB1 receptor finely tunes its interaction with G proteins and serves as a targeting signal for its functional regulation
we have associated cannabinoid 1 (CB1) receptor genetic variation rs2180619 (AA, AG, GG), which is located in a potential CNR1 regulatory sequence, with performance in working memory. no differences were found among genotypes while performing each working memory (WM) task. However, the cost of the level of complexity in N-back paradigm was double for GG subjects than for AA subjects.
phenotypes associated with rare CNR1 variants are reminiscent of those implicated in the theory of clinical endocannabinoid deficiency syndrome. The severe phenotypes associated with rare DAGLA variants underscore the critical role of rapid 2-AG synthesis and the endocannabinoid system in regulating neurological function and development
two agonist-bound crystal structures of human CB1 in complex with a tetrahydrocannabinol (AM11542) and a hexahydrocannabinol (AM841) at 2.80 A and 2.95 A resolution, respectively
that a genetically modulated balancing of signaling within the CB1-COX-2 pathway may reflect on more or less efficient patterns of prefrontal activity during working memory
In cotransfected HEK-293 cells, SSTR5 and CB1R existed in a constitutive heteromeric complex under basal condition, which was disrupted upon agonist treatments. Furthermore, concurrent receptor activation led to preferential formation of SSTR5 homodimer and dissociation of CB1R homodimer.
CB1R availability was inversely associated with BMI in homeostatic brain regions such as the hypothalamus and brainstem areas in both patients with food intake disorders(FID) and healthy subjects. However, in FID patients, CB1R availability was also negatively correlated with BMI throughout the mesolimbic reward system.
astrocytic TNFalpha levels were higher in GABA-Cnr1-/- mice, indicating that these morphological changes were accompanied by a more pro-inflammatory function. These findings demonstrate that the disruption of endocannabinoid signaling on GABAergic neurons is accompanied by functional changes in astrocyte activity, which are relevant to brain ageing
These findings suggest that CB1R expressed in KCs plays a critical role in obesity-related hepatic insulin resistance via a pro-inflammatory mechanism.
CB1R is a negative regulator of beta cell function and a mediator of islet inflammation under conditions of metabolic stress
Taste bud cells from CBR(-/-) mice also exhibited decreased Proglucagon and Glp-1r mRNA and a low GLP-1 basal level. We report that CBR is involved in fat taste perception via calcium signaling and GLP-1 secretion.
CNR1 deficiency attenuates insulin resistance and endoplasmic reticulum stress in heart of mice fed with high fat diet.
Results show that the subcellular CB1 receptor distribution in astrocytes in mice expressing CB1 receptors only in astrocytes completely matches the endogenous CB1 receptor expression and localization in astrocytes of the wild-type mouse hippocampus. Moreover, findings illustrate localization of CB1 receptors in astroglial mitochondria.
Results suggest that CB1R located on corticostriatal projections, by inhibiting glutamatergic transmission, protects dopamine D1 recpetor-medium spiny neurons not only from cortical mutant tHtt-evoked damage, as shown above, but also from astroglial mutant tHtt-evoked damage.
Results showed sensitivity of activated microglial cells to cannabinoids, increased CB1-CB2Het expression in activated microglia and in microglia from the hippocampus of an Alzheimer's model, and a correlation between levodopa-induced dyskinesia and striatal microglial activation in a Parkinson's disease model.
Study shows that independent of the neurochemical content, cholecystokinin/type 1 cannabinoid receptor-expressing interneurons have similar physiological and morphological properties, providing an endocannabinoid-sensitive synaptic inhibition onto the amygdalar principal neurons.
Study revealed distinct degrees of modulation for different emotional behaviors by the GABAergic population of cannabinoid CB1 receptors.
Combined deficiency of the Cnr1 and Cnr2 receptors protects against age-related bone loss by osteoclast inhibition.
Results show increased locomotor activity only in hypothyroid CB1R+/+ mice which is absent in those animals lacking this receptor, suggesting that the CB1R gene is essential for the establishment of the hyperlocomotor phenotype in hypothyroid animals. In parallel, a decreased response to haloperidol was observed only in hypothyroid CB1R+/+ mice, which may reflect an alteration in the dopamine D2 receptor (D2R) pathway.
The purpose of the studies in this report was to begin to explore the role of endocannabinoid signaling in Operant sensation seeking utilizing cannabinoid receptor 1 (CB1R) and fatty acid amide hydrolase (FAAH) knock out mice.
Data show that systemic, hippocampal, and peripheral blockade of cannabinoid type-1 (CB1) receptors abolished the stress-induced memory impairment.
this study shows that genetic or pharmacological depletion of cannabinoid CB1 receptor protects against dopaminergic neurotoxicity induced by methamphetamine in mice
CB1R knockout mice demonstrated increased injury following stroke, indicating that activation of the CB1R was neuroprotective, later studies of selective antagonists of the CB1R also demonstrated a protective effect
Findings demonstrate a critical distinction of the altered balance of glutamate-type 1 cannabinoid receptor and GABA-type 1 cannabinoid receptor activity that could participate in the vulnerability to cocaine abuse and addiction.
renal proximal tubule cell CB1R contributes to the pathogenesis of obesity-induced renal lipotoxicity and nephropathy by regulating the liver kinase B1/AMP-activated protein kinase signaling pathway
a protein involved in macroautophagy/autophagy (a conserved lysosomal degradation pathway), BECN2 (beclin 2), mediates cannabinoid tolerance by preventing CNR1 recycling and resensitization after prolonged agonist exposure, and deletion of Becn2 rescues CNR1 activity in mouse brain and conveys resistance to analgesic tolerance to chronic cannabinoids
genetic or chemical inhibition of cannabinoid receptor (Cnr) activity disrupts liver development and metabolic function in zebrafish.
The type 1 cannabinoid receptor lies upstream of CART and signals the appetite through the down-regulation of CART expression.
CB1 function is required in the early embryo for axonal growth and fasciculation.
This study provides unique evidence that the CB1R is dynamically and progressively involved from the start of mesial temporal lobe epileptogenesis
The result of this study provided a potential substrate for discrete, age-dependent effects of cannabinoid 1 receptor expression on the maturation of primate DLPFC circuitry.
The endocannabinoid system in renal cells: regulation of sodium transport by CB1 receptors through distinct cell signaling pathways
This study showed that FAAH gene expression was similar among high, medium and low fertile bulls and that CB1 expression was positively and significantly related to bull fertility.
Anandamide, through CB1 and TRPV1 activation, is involved in sperm release from the oviductal reservoir.
A novel mechanism has been identified underlying a CB1R-mediated increase in retinal ganglion cell intrinsic excitability acting through AMPK-dependent inhibition of NKCC1 activity.
CB1 functionality increased with development at both central and peripheral level.
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.
cannabinoid receptor 1
, central cannabinoid receptor
, brain-type cannabinoid receptor
, striatal cannabinoid receptor type 1 protein
, CB1 cannabinoid receptor
, cannabinoid receptor CB-1
, cannabinoid receptor 1 (brain)
, cannabinoid receptor 1-like
, cannabinoid 1 receptor
, cannabinoid receptor 1/CB1