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anti-Human CNR1 Antibodies:
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Human Polyclonal CNR1 Primary Antibody for WB - ABIN1881140
Van Laere, Casteels, Dhollander, Goffin, Grachev, Bormans, Vandenberghe: Widespread decrease of type 1 cannabinoid receptor availability in Huntington disease in vivo. in Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010
Show all 4 Pubmed References
Human Polyclonal CNR1 Primary Antibody for ELISA, WB - ABIN250833
Porcella, Maxia, Gessa, Pani: The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein. in The European journal of neuroscience 2000
Show all 3 Pubmed References
Human Polyclonal CNR1 Primary Antibody for ICC, IHC (fro) - ABIN152711
Mulhern, Madson, Danford, Ikesugi, Kador, Shinohara: The unfolded protein response in lens epithelial cells from galactosemic rat lenses. in Investigative ophthalmology & visual science 2006
The cannabinoid receptor 1 (CNR1) was identified as a direct target gene of miR1273g3pand knockdown of CNR1 restored the phenotypes of LoVo cells transfected with miR1273g3p inhibitor.
The Arg82 and Cys126 of CRIP1b (show CRIP1 Antibodies) are involved in the majority of hydrogen bond interactions with the CB1 receptor and are possible key residues required for interactions between the CB1 receptor and CRIP1b (show CRIP1 Antibodies)
The CB1 pathway is involved in the pathogenesis of shoulder stiffness. It may be a promising target for the treatment of rotator cuff (show CUFF Antibodies) lesions with shoulder stiffness.
CB1 receptors are among the most abundant G protein-coupled receptors in the brain that impact on several processes, including fear coping, anxiety, stress, learning, and memory. (Review)
CB1 receptor (CB1b) is highly expressed in pancreatic beta-cells and hepatocytes but not in the brain.
All of the epithelial layers in 94, 78, 96, 73 and 80% of pterygia cases, exhibited CB1, CB2 (show CNR2 Antibodies), TRPV1 (show TRPV1 Antibodies), TRPV2 (show TRPV2 Antibodies) and TRPV3 (show TRPV3 Antibodies) cytoplasmic immunoreactivity, respectively.
observed selective alterations of DNA methylation (show HELLS Antibodies) at the promoter of CNR1, the gene coding for the type-1 cannabinoid receptor, in schizophrenic patients with no changes in bipolar or major depressive disorder. In an animal model prefrontal cortex found a significant increase in CNR1 expression and a consistent reduction in DNA methylation (show HELLS Antibodies) at specific CpG sites of gene promoter.
This study of single-nucleotide polymorphisms in the cannabinoid receptor gene CNR1 showed that C carriers at rs806374 may be at specific risk for increased odds of cannabis use during the transition out of high school (around age 18).
results suggest that palmitoylation of the CB1 receptor finely tunes its interaction with G proteins and serves as a targeting signal for its functional regulation
we have associated cannabinoid 1 (CB1) receptor genetic variation rs2180619 (AA, AG, GG), which is located in a potential CNR1 regulatory sequence, with performance in working memory. no differences were found among genotypes while performing each working memory (WM) task. However, the cost of the level of complexity in N-back paradigm was double for GG subjects than for AA subjects.
Results show that the subcellular CB1 receptor distribution in astrocytes in mice expressing CB1 receptors only in astrocytes completely matches the endogenous CB1 receptor expression and localization in astrocytes of the wild-type mouse hippocampus. Moreover, findings illustrate localization of CB1 receptors in astroglial mitochondria.
Results suggest that CB1R located on corticostriatal projections, by inhibiting glutamatergic transmission, protects dopamine D1 recpetor-medium spiny neurons not only from cortical mutant tHtt-evoked damage, as shown above, but also from astroglial mutant tHtt-evoked damage.
Results showed sensitivity of activated microglial cells to cannabinoids, increased CB1-CB2Het expression in activated microglia and in microglia from the hippocampus of an Alzheimer's model, and a correlation between levodopa-induced dyskinesia and striatal microglial activation in a Parkinson's disease model.
Study shows that independent of the neurochemical content, cholecystokinin (show CCK Antibodies)/type 1 cannabinoid receptor-expressing interneurons have similar physiological and morphological properties, providing an endocannabinoid-sensitive synaptic inhibition onto the amygdalar principal neurons.
Study revealed distinct degrees of modulation for different emotional behaviors by the GABAergic population of cannabinoid CB1 receptors.
Combined deficiency of the Cnr1 and Cnr2 receptors protects against age-related bone loss by osteoclast inhibition.
Results show increased locomotor activity only in hypothyroid CB1R+/+ mice which is absent in those animals lacking this receptor, suggesting that the CB1R gene is essential for the establishment of the hyperlocomotor phenotype in hypothyroid animals. In parallel, a decreased response to haloperidol was observed only in hypothyroid CB1R+/+ mice, which may reflect an alteration in the dopamine D2 receptor (D2R (show DRD2 Antibodies)) pathway.
The purpose of the studies in this report was to begin to explore the role of endocannabinoid signaling in Operant sensation seeking utilizing cannabinoid receptor 1 (CB1R) and fatty acid amide hydrolase (FAAH (show FAAH Antibodies)) knock out mice.
Data show that systemic, hippocampal, and peripheral blockade of cannabinoid type-1 (CB1) receptors abolished the stress-induced memory impairment.
this study shows that genetic or pharmacological depletion of cannabinoid CB1 receptor protects against dopaminergic neurotoxicity induced by methamphetamine in mice
genetic or chemical inhibition of cannabinoid receptor (Cnr (show PCDHA1 Antibodies)) activity disrupts liver development and metabolic function in zebrafish.
CB1 function is required in the early embryo for axonal growth and fasciculation.
The endocannabinoid system in renal cells: regulation of sodium transport by CB1 receptors through distinct cell signaling pathways
This study showed that FAAH (show FAAH Antibodies) gene expression was similar among high, medium and low fertile bulls and that CB1 expression was positively and significantly related to bull fertility.
Anandamide, through CB1 and TRPV1 (show TRPV1 Antibodies) activation, is involved in sperm release from the oviductal reservoir.
A novel mechanism has been identified underlying a CB1R-mediated increase in retinal ganglion cell intrinsic excitability acting through AMPK (show PRKAA2 Antibodies)-dependent inhibition of NKCC1 (show SLC12A2 Antibodies) activity.
CB1 functionality increased with development at both central and peripheral level.
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.
cannabinoid receptor 1
, central cannabinoid receptor
, brain-type cannabinoid receptor
, striatal cannabinoid receptor type 1 protein
, CB1 cannabinoid receptor
, cannabinoid receptor CB-1
, cannabinoid receptor 1 (brain)
, cannabinoid receptor 1-like
, cannabinoid 1 receptor
, cannabinoid receptor 1/CB1