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We report a case of a nine-year-old male who presented with facial nerve stimulation four years after cochlear implantation. A dilated internal auditory meatus was revealed. Genetic analysis demonstrated X-linked deafness type 2 (DFNX2 (show POU3F4 Proteins)) caused by a novel c.769C T nucleotide change in the POU domain, class 3, transcription factor 4 (show TCF4 Proteins) gene
Brn3a cooperates with activated RAS/RAF (show RAF1 Proteins) signalling by reducing oncogene (show RAB1A Proteins)-induced senescence in melanocytic tumourigenesis.
Data indicate that median methylation levels of BCAN (show BCAN Proteins), HOXD1 (show HOXD1 Proteins), KCTD8 (show KCTD8 Proteins), KLF11 (show KLF11 Proteins), NXPH1 (show NXPH1 Proteins), POU4F1, SIM1 (show SIM1 Proteins), and TCF7L1 (show TCF3 Proteins) were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.
PoU4F1 is highly expressed in t(8;21) samples, with AML (show RUNX1 Proteins)/ETO (show RUNX1T1 Proteins) appearning to promote some BRN3A expression
BRN3A possesses anti-apoptotic property, and considering the above results, it may be regarded as the key component in promoting tumorigenic growth in the uterine cervical cells.
Ewing sarcoma induce expression of neuronal markers such as BRN3A showing that the function of those same markers may be restricted or controlled in an sarcoma-dependent manner.
Dysregulation of POU4F1 is associated with t(8;21) acute myeloid leukemia (show BCL11A Proteins).
genomic organization of the Brn-3a locus and the mechanisms that control the expression of two different proteins from one genomic locus
Measurement of Brn-3a levels in smears can be used to detect a significant proportion of cervical lesions that were missed by Pap (show REG3A Proteins) smear.
These results indicate that Brn-3a could play an important role in the near future in improving cervical cancer screening.
Double morphant embryos targeted with morpholino oligonucleotides to both TFs develop significant cardiac defects (looping abnormalities and valve defects) suggesting essential roles for Brn-3a and Brn-3b (show POU4F2 Proteins) in developing hearts.
Study demonstrates a sequential expression order of NEUROD1 (show NEUROD1 Proteins)>ISL1 (show ISL1 Proteins)>POU4F1>POU4F2 (show POU4F2 Proteins) during the inner ear neurogenesis.
Pou4f1 and pou4f2 (show POU4F2 Proteins) are dispensable for the long-term survival of adult retinal ganglion cells in mice.
The deficiency of Pou4f1 who perform poorly in motivation-based locomotor behaviors, such as voluntary wheel running and the accelerating rotarod, but show only minor abnormalities in gait and balance and exhibit normal levels of basal locomotion.
Data indicate that Brn3 transcription factors Brn3b (show POU4F2 Proteins) affects Brn3a and Brn3c (show POU4F3 Proteins) positive Retinal Ganglion Cells (RGCs) in cell autonomous and non-cell autonomous fashion.
The results demonstrated a critical role for Brn3a in generating dorsal root ganglia sensory neuron diversity and regulating sensory afferent projections to the central targets.
neither Brn3a nor Brn3c (show POU4F3 Proteins) are expressed in intrinsically photosensitive retinal ganglion cells
Brn3 gene expression patterns in the retina and inner ear, these experiments suggest a deep functional similarity among primary somatosensory neurons, spiral and vestibular ganglion neurons, and retinal ganglion cells
Progressive increase in IOP and loss of Brn3a signals in D2 animals were consistent with glaucoma progression starting after 6 months of age.
An epistatic interaction between Brn3a and Isl1 (show ISL1 Proteins) is key to sensory neuron specification, in their absence almost all known markers of sensory neurons are lost. Data support the hypothesis that Brn3a and Isl1 (show ISL1 Proteins) bind to shared enhancers in target genes.
This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias.
POU domain, class 4, transcription factor 1
, brain-specific homeobox/POU domain protein 3A
, homeobox/POU domain protein RDC-1
, POU class 4 homeobox 1
, brain-specific homeobox/POU domain protein 3a
, class IV POU-homeodomain protein
, LOW QUALITY PROTEIN: POU domain, class 4, transcription factor 1