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Neuropeptide Y (NPY) is a pleiotropic gene implicated in stress resilience and is associated with higher levels of conscientiousness. Along with environmental factors such as stressful life events, this gene may be a factor in the neurobiology of human personality.
We found the suicide-associated gene coexpression network. The reconstructed network consisted of 104 genes. Topological analysis showed that in total, CCK, INPP1, DDC, and NPY genes are the most fundamental hubs in the network.
Data indicated that NPY plays a protective role in ER stress-induced neuronal cell death through activation of the PI3K-XBP1 pathway.
This study provided proof that SNPs within NPY is significantly associated with the susceptibility to and the prognosis of cervical vertigo.
Data suggest that up-regulation of NPY inhibits proliferation of adipose-derived stem cells while promoting adipogenesis and up-regulating expression of white adipocyte biomarkers PPARG, CEBPA, CIDEC, and RIP140. (PPARG = peroxisome proliferator activated receptor gamma; CEBPA = CCAAT/enhancer-binding protein alpha; CIDEC = cell death-inducing DFFA-like effector C; RIP140 = nuclear receptor interacting protein 1)
results are the first to demonstrate that functional NPY variation alters chronic stress-related vagal control, suggesting a potential parasympathetic role for NPY gene in stress regulation
Medium chain triglyceride nutritional supplementation increased the amount of activated ghrelin and NPY in anorexia nervosa patients.
Analysis indicates that low levels of NPY in psychogenic non-epileptic seizure patients may confer greater vulnerability to exhibit seizure-like symptoms and lower quality of life.
The rs16147 genotype affected the reduction in insulin resistance and insulin levels in response to two different hypocaloric diets in obese subjects, with a lack of response in subjects with the major allele.
We found that the NPY gene rs16147 SNP was related to the change in insulin levels, homeostasis model assessment-insulin resistance, CRP, IL-6 and waist circumference at 3 months after a hypocaloric low-fat diet.
genetic variation in NPY and NPY2R is at low frequency and thus does not make a major contribution to the obese phenotype in the general population
Genetic risk score (GRSNPY) analysis found twelve significant (P<0.05) serum NPY concentration related SNPs among alpha7 nicotinic acetylcholine receptor gene CHRNA7, insulin receptor gene INSR, leptin receptor gene LEPR, glucocorticoid receptor (GR) gene NR3C1, and NPY gene. However, after permutation test of gene score the predictive value of GRSNPY remained non-significant (P=0.078). CONCLUSIONS: Serum NPY level ...
In obese males, the rs164147 polymorphism of the NPY gene is associated with leptin, insulin level, HOMA-IR, and an increased risk of MetS and its related phenotypes, such as central obesity and hyperglycemia.
Both structural (+1128T/C) and promoter polymorphisms (-399 T/C) of Neuropeptide Y are strongly associated with type-II diabetes susceptibility in Gujarat population which at least in part, may result in higher levels of Neuropeptide Y thereby suggesting its crucial role in type-II diabetes susceptibility.
Hypermethylation of WIF1 (WNT inhibitory factor 1) and NPY (neuropeptide Y) genes was significantly higher in tumor tissue compared to normal tissue, independently of tumor stage.
Our results provided clinical evidences for NPY participating in the bone healing process in a nonhypothalamic manner, most probably by directly promoting osteogenesis of mesenchymal stem cells.
In conclusion, the obtained results demonstrate the probable role of NPY SNPs in susceptibility to multiple sclerosis within the Iranian population.
Neuropeptide Y is the best dipeptidyl peptidase 4 (DPP4)-substrate in blood, being truncated by soluble and membrane DPP4, respectively. The decline of soluble DPP4 in acute depression could be reversed upon anti-depressive treatment.
The CT genotype of rs5574 and the GT genotype of rs17149106 are significantly associated with prevalent asthma.
study implicates NPY as a potential target in antihypertensive therapies for preeclampsia patients
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases.
, pro-neuropeptide Y