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anti-Rat (Rattus) Antibodies:
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Data suggest that up-regulation of NPY (show NPY Antibodies) inhibits proliferation of adipose-derived stem cells while promoting adipogenesis and up-regulating expression of white adipocyte biomarkers PPARG (show PPARG Antibodies), CEBPA (show CEBPA Antibodies), CIDEC (show CIDEC Antibodies), and RIP140 (show NRIP1 Antibodies). (PPARG (show PPARG Antibodies) = peroxisome proliferator activated receptor gamma (show PPARG Antibodies); CEBPA (show CEBPA Antibodies) = CCAAT/enhancer-binding protein alpha (show CEBPA Antibodies); CIDEC (show CIDEC Antibodies) = cell death-inducing DFFA-like effector C (show CIDEC Antibodies); RIP140 (show NRIP1 Antibodies) = nuclear receptor interacting protein 1 (show NRIP1 Antibodies))
results are the first to demonstrate that functional NPY (show NPY Antibodies) variation alters chronic stress-related vagal control, suggesting a potential parasympathetic role for NPY (show NPY Antibodies) gene in stress regulation
Medium chain triglyceride nutritional supplementation increased the amount of activated ghrelin (show GHRL Antibodies) and NPY (show NPY Antibodies) in anorexia nervosa patients.
Analysis indicates that low levels of NPY (show NPY Antibodies) in psychogenic non-epileptic seizure patients may confer greater vulnerability to exhibit seizure-like symptoms and lower quality of life.
The rs16147 genotype affected the reduction in insulin (show INS Antibodies) resistance and insulin (show INS Antibodies) levels in response to two different hypocaloric diets in obese subjects, with a lack of response in subjects with the major allele.
We found that the NPY (show NPY Antibodies) gene rs16147 SNP was related to the change in insulin (show INS Antibodies) levels, homeostasis model assessment-insulin (show INS Antibodies) resistance, CRP (show CRP Antibodies), IL-6 (show IL6 Antibodies) and waist circumference at 3 months after a hypocaloric low-fat diet.
genetic variation in NPY (show NPY Antibodies) and NPY2R (show NPY2R Antibodies) is at low frequency and thus does not make a major contribution to the obese phenotype in the general population
Genetic risk score (GRSNPY) analysis found twelve significant (P<0.05) serum NPY (show NPY Antibodies) concentration related SNPs among alpha7 nicotinic acetylcholine receptor gene CHRNA7 (show CHRNA7 Antibodies), insulin receptor (show INSR Antibodies) gene INSR (show INSR Antibodies), leptin receptor (show LEPR Antibodies) gene LEPR (show LEPR Antibodies), glucocorticoid receptor (GR (show NR3C1 Antibodies)) gene NR3C1 (show NR3C1 Antibodies), and NPY (show NPY Antibodies) gene. However, after permutation test of gene score the predictive value of GRSNPY remained non-significant (P=0.078). CONCLUSIONS: Serum NPY (show NPY Antibodies) level ...
In obese males, the rs164147 polymorphism of the NPY (show NPY Antibodies) gene is associated with leptin (show LEP Antibodies), insulin (show INS Antibodies) level, HOMA-IR, and an increased risk of MetS (show ETV3 Antibodies) and its related phenotypes, such as central obesity and hyperglycemia.
Both structural (+1128T/C) and promoter polymorphisms (-399 T/C) of Neuropeptide Y (show NPY Antibodies) are strongly associated with type-II diabetes susceptibility in Gujarat population which at least in part, may result in higher levels of Neuropeptide Y (show NPY Antibodies) thereby suggesting its crucial role in type-II diabetes susceptibility.
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases.
, pro-neuropeptide Y