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GLUD1 Products

(Glutamate Dehydrogenase 1 (GLUD1))
This gene encodes glutamate dehydrogenase protein\; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.[provided by RefSeq, Sep 2009].

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Featured GLUD1 Categories

GLUD1 Antibodies

High quality antibodies with extensive validation data.

GLUD1 ELISA Kits

Reliable ELISA kits for a wide range of species.

GLUD1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended GLUD1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet

Application IHC, WB
Validations
  • (2)
  • (13)
Cat. No. ABIN2782330
Quantity 100 μL
Datasheet Datasheet

Application IHC, WB
Validations
  • (6)
Cat. No. ABIN2782329
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application ICC, IF, IHC (p), ELISA, WB
Validations
  • (1)
  • (3)
Cat. No. ABIN2856181
Quantity 100 μL
Datasheet Datasheet

Recommended GLUD1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6962890
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6962766
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6956140
Quantity 96 tests
Datasheet Datasheet

Recommended GLUD1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3078929
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3133474
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5853669
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our GLUD1 products

Geiszler, Ugun-Klusek, Lawler, Pardon, Yuchun, Bai, Daykin, Auer, Bedford: "Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons." in: Scientific reports, Vol. 8, Issue 1, pp. 4833, (2019) (PubMed).

Karri, Singh, Paripati, Marada, Krishnamoorthy, Guruprasad, Balasubramanian, Sepuri: "Adaptation of Mge1 to oxidative stress by local unfolding and altered Interaction with mitochondrial Hsp70 and Mxr2." in: Mitochondrion, (2018) (PubMed).

Rueda, Johnson, Giddabasappa, Swaroop, Brooks, Sigel, Chaney, Fox: "The cellular and compartmental profile of mouse retinal glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and ~P transferring kinases." in: Molecular vision, Vol. 22, pp. 847-85, (2016) (PubMed).

Knudsen, Balaji, Freinkman, McCue, Witkiewicz: "Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential." in: Oncotarget, Vol. 7, Issue 48, pp. 78396-78411, (2016) (PubMed).

Li, Li, Li, Zhong, Ji, Yu, Zhang, Wen, Zhang, Goscinski, Nesland, Suo: "PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence." in: Oncotarget, Vol. 7, Issue 33, pp. 53837-53852, (2016) (PubMed).

Spanaki, Kotzamani, Plaitakis: "Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions." in: Neurochemical research, Vol. 42, Issue 1, pp. 92-107, (2016) (PubMed).

Spanaki, Kotzamani, Petraki, Drakos, Plaitakis: "Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues." in: Molecular and cellular endocrinology, Vol. 415, pp. 1-11, (2015) (PubMed).

Pougovkina, te Brinke, Ofman, van Cruchten, Kulik, Wanders, Houten, de Boer: "Mitochondrial protein acetylation is driven by acetyl-CoA from fatty acid oxidation." in: Human molecular genetics, Vol. 23, Issue 13, pp. 3513-22, (2015) (PubMed).

Jeong, Lee, Lee, Haigis: "SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma." in: The Journal of biological chemistry, Vol. 289, Issue 7, pp. 4135-44, (2014) (PubMed).

Yang, Ko, Hensley, Jiang, Wasti, Kim, Sudderth, Calvaruso, Lumata, Mitsche, Rutter, Merritt, DeBerardinis: "Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport." in: Molecular cell, Vol. 56, Issue 3, pp. 414-24, (2014) (PubMed).

Synonyms and alternative names related to GLUD1

glutamate dehydrogenase 1 (GLUD1), glutamate dehydrogenase 1 (GDH1), glutamate dehydrogenase 1 (glud1), glutamate dehydrogenase 1 S homeolog (glud1.S), glutamate dehydrogenase 1, mitochondrial (LOC693461), glutamate dehydrogenase 1b (glud1b), glutamate dehydrogenase 1 (Glud1), glutamate dehydrogenase (HACJB3_RS00320), glutamate dehydrogenase 1, mitochondrial (LOC100587725), non-compact myelin associated protein (NCMAP), glutamate dehydrogenase (gdh1), Ac2-281, AI118167, C2H1orf130, cb719, GDH, Gdh-X, gdh1, GDH 1, GDH1, Gdh1, GLUD, Glud, glud1, GLUD1, Gludeha, Gludl, GLUTAMATE DECARBOXYLASE 1, GLUTAMATE DEHYDROGENASE 1, glutamate dehydrogenase 1, legdh1, MRG-2, MRG7.13, MRG7_13, wu:fb16e02, wu:fb58f12, wu:fe37f03, wu:fj43f02, zgc:55630, zgc:192851

Protein level used designations for GLUD1

  • GDH 1
  • glutamate dehydrogenase 1, mitochondrial
  • glutamate dehydrogenase 1
  • mitochondrial glutamate dehydrogenase 1
  • glutamate dehydrogenase (NAD(P)+)
  • memory-related gene 2 protein
  • glutamate dehydrogenase 1, mitochondrial-like
  • Legdh1
  • NADH-glutamate dehydrogenase
  • glutamate dehydrogenase
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