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anti-Human B4GALT1 Antibodies:
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Human Polyclonal B4GALT1 Primary Antibody for ICC, IF - ABIN4284385
Stalder, Heusermann, Sokol, Trojer, Wirz, Hean, Fritzsche, Aeschimann, Pfanzagl, Basselet, Weiler, Hintersteiner, Morrissey, Meisner-Kober: The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing. in The EMBO journal 2013
Study solved the crystal structure of the wild-type human B4GalT1 homodimer and showed that B4GalT1 exists in a dynamic equilibrium between monomer and dimer. These two crystal forms revealed the unliganded B4GalT1 in both the open and the closed conformation of the Trp loop and the lid regions, responsible for donor and acceptor substrate binding, respectively.
Study indicated that B4GALT1 may be a possible prognosticator of muscle-invasive bladder cancer, and it may be a predictive marker for the choice of adjuvant chemotherapy in pT3/4 or N+ patients.
Human beta-1,4-GalT1 is a constitutively expressed mesangial cell IgA receptor with an important role in both mesangial IgA clearance and the initial response to IgA deposition.
Increased B4GALT1 expression is a potential independent adverse prognostic factor for overall survival in patients with non-metastatic clear cell renal cell carcinoma.
demonstrated that ZFX is aberrantly expressed in multiple human leukemic cells and it modulates the growth and drug response of leukemic cells partially via B4GALT1, which suggests that ZFX is a new regulator of leukemic cells and warrants intensive investigations on this 'stemness' regulator in these deadly diseases
High B4GALT1 expression is associated with aging.
We suggest that the unique expression patterns for the B4GALT1 in normal and malignant tissues are controlled by a differential usage of 5'-B4GALT1 regulatory units along with a post-transcriptional regulation by the antisense RNA
Human chorionic gonadotropin provides a mechanism to bridge embryo to endometrium through beta1,4-GalT.
HS5 cells had significantly enhanced levels of bisecting N-glycans (catalyzed by MGAT3 whereas HS27a cells had enhanced levels of Galbeta1,4GlcNAc.
plays a role in activation of T-lymphocytes and participates in intercellular contact formation
B4GALT1 and B4GALT5, two members of B4GALT gene family, are involved in the development of multidrug resistance of human leukemia cells.
the glycogene B4GALT1 represent a valuable candidate biomarker of invasive phenotype of colorectal cancer.
RNAi-mediated knockdown of beta1,4GT1 increased the levels of EGFR dimerization and phosphorylation. These data suggest that cell surface beta1,4GT1 interacts with EGFR and inhibits EGFR activatio
estrogen regulates the expression of B4GALT1 through the direct binding of ER-alpha to ERE; the expressed B4GALT1 plays a crucial role in the proliferation of MCF-7 cells through its activity as a membrane receptor.
Osteopontin increases the expression of beta1, 4-Galactosyltransferase-I and promotes adhesion in human RL95-2 cells, the activity critical for embryo implantation.
expression of beta1,4-GalT-I increased in the cartilage and synovial tissue of osteoarthritis (OA) patients compared with healthy controls; data suggest that beta1,4-GalT-I may play an important role in the inflammatory processes in cartilage and synovial tissue of patients with OA
beta4Gal-T1 molecule has two different oligosaccharide binding regions for the binding of the extended oligosaccharide moiety of the acceptor substrate.
TNF-alpha contributes to the up-regulation of beta1,4-GalT-I mRNA in human fibroblast-like synoviocytes.
These results suggested that beta1,4-Galactosyltransferase-I may play an important role in the inflammatory processes in synovial tissue of patients with rheumatoid arthritis.
B4GalTI might act as a key adhesion molecule participating in T cell-dendritic cell contacts.
The loss of the long GalT-I isoform also leads to a loss of actin stress fibers, focal adhesions and rac GTPase activation.
beta4GalT1 can regulate N-glycans of CXCR3 in RA. N-glycans of CXCR3 affects CXCL10/CXCR3 ligand-binding which enhancing fibroblast-like synoviocytes invasion.
Beta 1,4-galactosyltransferase I possibly regulate mutual uterus-embryo adhesion and embryo implantation by regulating cell surface Le(Y) glycan expression.
revealed increased expression of polylactosamines on B4galt1(+/-) B cells and macrophages, compared with B4galt1(+/+) cells
beta4GalT-I is a major galactosyltransferase responsible for selectin-ligand biosynthesis and that inflammatory responses of beta4GalT-I-deficient mice are impaired because of the defect in selectin-ligand biosynthesis.
the beta4-galactosyltransferase-1 coding sequence does not contain functional elements that affect the intrinsic stability of this mRNA
regulation of expression by focal adhesion kinase
REVIEW: Function in mammary gland morphogenesis: insights from transgenic and knockout mouse models
Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis.
Hypothesized that engineering B4GALT1 to block cleavage and secretion would enhance its retention and its function; to test this hypothesis, replaced CTS domains of bovine B4GALT1 with those from human FUT7, which is not cleaved and secreted.
the beta4galt1 gene is potentially associated with milk production traits in dairy cows and should be considered for further studies on genetics of the milk production traits.
Crystal structure of mutant Met344His beta4Gal-T1 defined at 2.3 angstrom resolution reveals that the N-acetylglucosamine residue at nonreducing end of chitobiose makes extensive hydrophobic interactions with highly conserved tyrosine-286 of beta4Gal-T1.
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose\; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase.
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1
, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1
, beta-1,4-GalTase 1
, beta-1,4-galactosyltransferase 1
, glycoprotein-4-beta-galactosyltransferase 2
, lactose synthase
, b1,4-Galactosyltransferase I
, galactosyltransferase 2 beta 1, 4
, glycoprotein galactosyltransferase beta 1, 4
, Glycoprotein-4-beta-galactosyltransferase 2
, beta-galactosyltransferase 2 (glycoprotein)
, UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1