B4GALT1 Proteins
8 UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1) Proteins from 4 manufacturers are available on www.antibodies-online.com.
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UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1) (AA 1-399) protein (rho-1D4 tag) Protein
UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1) (AA 45-398) protein (His tag) Protein
UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1) (AA 45-399) protein (His tag) Protein
UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1) (AA 1-398) protein (rho-1D4 tag) Protein
UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1) (AA 44-398), (Extracellular Domain) protein (His tag) Protein
UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1) (AA 44-153) protein (GST tag) Protein
UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1) (Active) Protein Protein
UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 1 (B4GALT1) Protein Protein
B4GALT1 Protein Profile
Protein Summary
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose\; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase.
Alternative names and synonyms associated with B4GALT1
- beta-1,4-galactosyltransferase 1 (B4GALT1) antibody
- UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (B4galt1) antibody
- beta-1,4-galactosyltransferase 1 (B4galt1) antibody
- B-1,4-GalT antibody
- B-1,4-GalT1 antibody
- b4Gal-T1 antibody
- beta-1,4-GalT antibody
- beta-1,4-GalT1 antibody
- beta4Gal-T1 antibody
- CDG2D antibody
- GalT antibody
- Ggtb antibody
- Ggtb2 antibody
- GT1 antibody
- GTB antibody
Protein level used designations for B4GALT1
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1 , UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1 , beta-1,4-GalTase 1 , beta-1,4-galactosyltransferase 1 , glycoprotein-4-beta-galactosyltransferase 2 , lactose synthase , b1,4-Galactosyltransferase I , galactosyltransferase 2 beta 1, 4 , glycoprotein galactosyltransferase beta 1, 4 , Glycoprotein-4-beta-galactosyltransferase 2 , b4Gal-T1 , beta4Gal-T1 , beta-galactosyltransferase 2 (glycoprotein) , UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
GENE ID | SPECIES |
---|---|
2683 | Homo sapiens |
14595 | Mus musculus |
24390 | Rattus norvegicus |
281781 | Bos taurus |
100345726 | Oryctolagus cuniculus |
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