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Study provides evidence that mutations in B3GNT2 (show B3GNT2 Proteins), B4GALT2, and ST6GALNAC2 (show ST6GALNAC2 Proteins) underlie aberrant glycosylation, and contribute to the pathogenesis of molecular subsets of colon and other gastrointestinal malignancies.
Significance of core 2 GlcNAc-T (show GCNT1 Proteins) in the pathogenesis of capillary occlusion in diabetic retinopathy.
results suggested that beta1,4GalT II might serve as a target gene of p53 (show TP53 Proteins) transcription factor during adriamycin-induced HeLa cell apoptosis, which elucidated a new mechanism of p53 (show TP53 Proteins)-mediated cell apoptosis
Data show that Beta4-Gal (show GAL Proteins)-transferase (beta4GalT) extends core 2 and forms the backbone structure for biologically important epitopes.
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose\; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene.
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2
, UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 2
, UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 2
, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2
, beta-1,4-GalTase 2
, beta-1,4-galactosyltransferase 2
, beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 2
, beta-1,4-galactosyltransferase II
, UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
, Beta-1,4-GalTase 2