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anti-Human Glucuronidase beta Antibodies:
anti-Mouse (Murine) Glucuronidase beta Antibodies:
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The aim of this study was to compare the levels of electrolytes, inorganic phosphatase, and alkaline phosphatease, acid phosphatase, and beta-glucuronidase.
the beta-d-galactosidase, beta-d-glucuronidase and alpha-l-fucosidase activities in serums from hemolyzed blood, were determined.
Results show that GUS mRNA changes in blood are significantly correlated with gait step length variability in premutation (PM) females patients with fragile X tremor ataxia syndrome .
We produced GUS from a CHO cell line grown in suspension in a 15 L perfused bioreactor and developed a three step purification procedure that yields approximately 99% pure enzyme with a recovery of more than 40%.
Selective and amplified bG expression together with the prodrug DOXGA3 had an increased antitumor effect, showing great potential for prostate cancer therapy.
the use of in silico approaches provided a useful understanding of the effect of single point mutations on the structure-function relationship of GUSBp
the efficacy of a helper-dependent (HD) canine adenovirus (CAV-2) vector harboring a human GUSB expression cassette (HD-RIGIE) in the MPS VII dog brain was tested
This assessment demonstrated that although butyrate dramatically increased beta-glucuronidase production in bioreactors, it adversely impacted the mannose-6-phosphorylation of this lysosomal storage diseasestherapeutic enzyme
expression of CES2, UGTA1A1, and GUSB varies in colorectal pathology tissues and that the expression of CES2 is somewhat related to tumor staging.
GUSB and ATP2B4 have been validated as a reliable gene combination for Cystic Fibrosis Transmembrane Conductance Regulator gene qPCR data normalization.
Liver disease affects the expression of common HKGs; beta-glucuronidase and splicing factor arginine/serine-rich 4 are the most stable HKGs for studies of gene expression in HCV-infected human liver.
beta-glucuronidase mutations are associated with mucopolysaccharidosis type VII
Recombinant adeno-associated virus encoding human GUSB injected into the vitreous humor of young adult MPS VII mice increased GUSB activity and reduced lysosomal distension in regions of the thalamus and tectum
beta glucuronidase present in the synovial fluid of rheumatoid arthritis patients, may contribute to the depletion of glycosaminoglycans from cartilage allowing invasion of synovial cells.
Over-expression of beta-glucuronidase was related to the degree of cancer differentiation, but not to lymph node metastasis.
These results indicate that beta-glucuronidase transport into brain parenchyma in early postnatal life is mediated by the mannose 6-phosphate/insulin-like growth factor II receptor.
The genes GUS and PMM1 are recommended for normalization purposes in gene expression studies of liver tissue from patients with chronic hepatitis.
Study summarized information on the 49 unique, disease-causing mutations determined so far in the GUS gene.
Administration of murine beta-glucuronidase to MPS VII mice at 4months of age, when bone disease was fully manifested, using lentiviral gene delivery resulted in a doubling of osteoclast numbers and a significant increase in attachment capacity (68% versus 29.4% in untreated MPS VII animals). Bone mineral volume rapidly decreased by 39% after gene therapy and fell within the normal range by 6months of age
beta-Glucuronidase, a Regulator of Lyme Arthritis Severity, Modulates Lysosomal Trafficking and MMP-9 Secretion in Response to Inflammatory Stimuli
GUSB modulates arthritis pathogenesis by preventing accumulation of proinflammatory glycosaminoglycans within inflamed joint tissue.
The Gus plays a role in liver retinoid metabolism.
Missense mutations and models of murine mucopolysaccharidosis type VII produced by targeted mutagenesis
data indicate the expression of beta-glucuronidase coordinated with testosterone level in male CBA mice but not C57BL/6 mice
Lysosome storage in the mucopoysaccharidosis type VII brain was corrected by injection of an HSV-1 genetic vector and expression of Gusb was assayed. genetic vector
AnxA6 is a novel receptor that mediates the endocytosis of bovine beta-glucuronidase.
This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. There are many pseudogenes of this locus in the human genome.
, Beta-glucuronidase (gusB)
, adipose storage deficiency