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Data suggest that ganglioside glycosyltransferases ST3GAL5 (show ST3GAL5 Proteins), ST8SIA1 (show ST8SIA1 Proteins), and B4GALNT1 (show B4GALNT1 Proteins) are S-acylated at conserved cysteine residues located close to cytoplasmic border of their transmembrane domains; ST3Gal-II is acylated at conserved cysteine residue in N-terminal cytoplasmic tail; for B4GALNT1 (show B4GALNT1 Proteins) and ST3Gal-II, dimer formation controls their S-acylation status.
This suggests that the C-terminal domain of ST3Gal-II depends on N-glycosylation to attain an optimum conformation for proper exit from the endoplasmic reticulum
Genomic structure, expression, and transcriptional regulation of ST3GALII.
ST3Gal II is a MSGb5 (stage-specific embryonic antigen-4) synthase and its increased expression level is closely related to renal carcinogenesis
t3gal2-null mice display a reduced respiratory exchange ratio compared to WT mice, indicating a preference for lipid oxidation as an energy source. Despite their altered metabolism, St3gal2-null mice were hyperactive. We conclude that altered ganglioside expression in adipose tissue results in diminished IR sensitivity and late-onset obesity.
St3gal2/3 double-null mice displayed dysmyelination marked by a reduction in major myelin proteins, fewer myelinated axons, a decrease in myelin thickness, possibly by dysregulation of ganglioside-mediated oligodendroglial precursor cell proliferation.
An adult onset cardiac dilatation in a transgenic mouse line with Galbeta1,3GalNAc alpha2,3-sialyltransferase (show ST3GAL5 Proteins) II (ST3Gal-II) transgenes, is reported.
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4A.
, alpha 2,3-sialyltransferase ST3Gal II
, st3Gal II.2
, alpha-2,3-sialyltransferase ST3Gal I-r1
, ST3Gal II
, alpha 2,3-ST 2
, beta-galactoside alpha-2,3-sialyltransferase 2
, beta-galactoside alpha-2,3-sialytransferase
, sialyltransferase 4B (beta-galactosidase alpha-2,3-sialytransferase)
, sialyltransferase ST3Gal-II
, sialyltransferase 4B
, sialyltransferase 5
, sialyltransferase 4B (beta-galactoside alpha-2,3-sialyltransferase)