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Structural Determinants for the Interactions of Chemically Modified Nucleic Acids with the Stabilin-2 Clearance Receptor.
Data show that the hyaluronan receptor for endocytosis (HARE) NPLY2519 motif is necessary for both extracellular signal-regulated kinases ERK1/2 and NF-kappa B (NF-kappaB)signaling and that Tyr2519 is critical for these functions.
Stabilin-2 can play a critical role in the first entrapping step of LN metastasis through homotypic interaction with the lymphatic endothelium and appears to be a tumor biomarker predicting for LN metastasis in patients with solid tumors
HARE/Stabilin-2 splice variants are expressed in bone marrow, lymph node, and spleen
a Link domain complex N-glycan is required specifically for HARE.hyaluronic acid-mediated activation of ERK1/2 and NF-kappaB-mediated gene expression
Loss of Stabilin-2 expression in peri-tumourous transdifferentiated liver endothelial cells correlates with increased survival by preventing endothelial-tumour cell adhesive interactions and microvascular invasion.
HARE may be part of a systemic tissue-stress sensor feedback system that responds to abnormal tissue turnover or damage as a danger signal
stabilin-2 acts as a receptor for necrotic cell clearance.
Hyaluronan binding to HARE mediates NF-kappaB-activated gene expression in a dose-dependent manner.
knockdown of endogenous alphavbeta5 expression or treatment with a function-blocking alphavbeta5 antibody significantly decreased stabilin-2-mediated phagocytosis in the absence of soluble factors
Ligament Flavum (LF) hypertrophy is accompanied by increased CD44 and CD44v5 expression. CD44v6 expression is not enhanced in LF hypertrophy.
The results indicate that Link domain N-glycans stabilize interactions that facilitate HA binding to HARE.
code for homologous transmembrane proteins featuring seven fasciclin-like adhesion domains, 18-20 epidermal-growth-factor domains, one X-link domain and three to six B-(X(7))-B hyaluronan-binding motifs
amino acid sequence of 190-kDa protein composed of 1416 amino acids and alignment with rat sequence
HARE has a role in endocytosis and species-specific glycosaminoglycan affinity
A majority of HARE isoform is intracellular, within the endocytic system, suggesting transient surface residency typical of an active endocytic recycling receptor.
study provides evidence that stabilin-2 is a novel phosphatidylserine receptor, which performs a key function in the rapid clearance of cell corpses
GULP is a likely downstream molecule in the stabilin-2-mediated signaling pathway and plays an important role in stabilin-2-mediated phagocytosis
when HARE binds HA, that leads to activation of ERK1/2, important mediators of intracellular signal transduction.
HARE in the sinusoidal endothelial cells of lymph nodes and liver likely mediates the efficient systemic clearance of Hep and many different Hep-binding protein complexes from the lymphatic and vascular c
HOXC9 regulates formation of parachordal lymphangioplasts and the thoracic duct in zebrafish via stabilin 2.
Stabilin-2 interacts with G protein-coupled receptor BAI3 (BAI3) and stimulates its fusion promoting activity. Stabilin-2 activates the GPCR activity BAI3. The resulting activated heterotrimeric G-proteins contribute to the initial recruitment of Elmo proteins to the membrane, which are then stabilized on BAI3 through a direct interaction.
Data show that stabilin-1 and stabilin-2 differentially expressed in isolated pancreatic Islets.
Stab2 recognizes phospatidylserine exposed on apoptotic cells for sensing as an "eat-me" signal.
Results show that Stab2 contributes to phosphatidylserine-dependent myoblast fusion and provide new insights into the molecular mechanism by which phosphatidylserine mediates myoblast fusion during muscle growth and regeneration.
A dramatic elevation in circulating hyaluronic acid levels in Stab2-deficient mice without any overt phenotype, is reported.
Adrenomedullin treatment from day 14 to day 20 promoted the differentiation of stabilin-2-positive endothelial cells.
we show that stabilin-1 and stabilin-2 in hepatic sinusoidal endothelial cells (HSECs) are critical in effectively clearing damaged RBCs in mouse liver
Data suggest that stabilin-1 and -2 together guarantee proper hepatic clearance of potentially noxious agents in the blood and maintain tissue homeostasis not only in the liver but also distant organs.
FEEL-1 and this protein are endocytic receptors for advanced glycation end products.
mStab-2 might be involved in the clearance of hyaluronan from the lymph or the blood circulation via the network of endothelial sinuses
analysis of mouse fasciclin-containing genes (betaigH3, periostin, stabilin-1, and stabilin-2) expression patterns during valvuloseptal morphogenesis
describe the development of hepatic sinusoids in mice based on the expression of hyaluronan receptors Stab2 and Lyve-1
Stabilin-2-mediated aggregation is mediated by homophilic interactions and enhanced in the presence of Ca(2+) and Mg(2+). Interestingly, exogenous addition of FAS1 domains but not EGF-like domains enhances stabilin-2-mediated cell aggregation
stabilin-2 contributes to adhesion and homing of circulating stem and progenitor cells to bone marrow.
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes.
CD44-like precursor FELL
, FAS1 EGF-like and X-link domain containing adhesion molecule-2
, fasciclin egf-like, laminin-type egf-like, and link domain-containing scavenger receptor-2
, hepatic hyaluronan clearance receptor
, hyaluronan receptor for endocytosis
, hyaluronic acid receptor for endocytosis
, stabilin 2
, novel EGF-like domain containing protein
, fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2
, scavenger receptor FEEL-2
, putative hyaluronan receptor for endocytosis