Browse our TGFBR1 Proteins (TGFBR1)

Human Transforming Growth Factor, beta Receptor 1 (TGFBR1) interaction partners

1. TGFBR1 mutations were more frequent among Loeys-Dietz syndrome patients with motor delays and feeding issues.

2. Results show that TGFBR1 is upregulated in nonsmall cell lung cancer (NSCLC) that its 3'UTR is a direct target for miR98.

3. Mutations in TGFBR1 exon 5 cause either Loeys-Dietz syndrome or multiple self-healing squamous epithelioma.

4. The majority of the identified P/LP variants were in the FBN1 gene ..we found 4.9% of patients carried a P/LP variant as the underlying cause of their Thoracic aortic aneurysm/aortic dissection (TAAD), predominantly within FBN1 but with substantial contributions from TGFBR and COL genes.

5. Long non-coding RNA SBF2-AS1 modulated TGFBR1 through sponging miR-140-5p in hepatocellular carcinoma development and progression.

6. GPR50 is a TbetaRI co-receptor with potential impact on cancer development

7. Systemic activation of Activin A signaling causes chronic kidney disease-mineral bone disorder. (Review)

8. TGFbetaR1 rs10739778 was associated with blood pressure in healthy pregnant women.

9. Treatment of T. cruzi-infected cardiac spheroids with SB 431542, a selective inhibitor of TGF-b type I receptor, resulted in a reduction in the size of spheroids, which was accompanied by a decrease in parasite load and in fibronectin expression.

10. TGFBR1/2 genetic variants (in particular when evaluated as a burden by score) might play a role in modulating the severity of cardiovascular manifestation in Marfan syndrome.

11. Inhibition of each TGFbeta receptor-I, glucocorticoid receptor or JNK signaling partially reversed the dexamethasone-mediated effects, suggesting a complex signaling network. These data reveal that dexamethasone mediates progression by membrane effects and binding to glucocorticoid receptor

12. DZNep induced miR-202-5p to target both TGFbeta receptors, TGFBR1 and TGFBR2...transfection of anti-miRNAs against miR-202-5p resulted in increased TGFBR1 and TGFBR2 protein expressions and induced EMT characteristics in these cells. In stellate pancreatic cells, miR-202 overexpression slowed growth as well as reduced stromal extracellular membrane matrix protein expression

13. Findings provide evidence that TGFBR-1 expression is regulated by SLC35F2 which exerts its oncogenic effect on papillary thyroid carcinoma progression through activation of TGFBR-1 and ASK-1.

14. rs334348 polymorphism may influence individual's susceptibility to endometriosis and its severity

15. miR-130a-3p might play a critical role in negatively regulating hepatic stellate cell activation and proliferation in the progression of nonalcoholic fibrosing steatohepatitis by directly targeting TGFBR1 and TGFBR2 via the TGF-beta/SMAD signaling pathway.

16. TGFbetaR1 signaling was involved in 14-3-3zeta-mediated cell proliferation and metastasis of lung squamous cell carcinoma cells.

17. Mutational activation of BRAF confers sensitivity to TGFBR1 inhibitors in human melanoma cells.

18. Loeys-Dietz syndrome patients with confirmed mutations in TGFBR1 or TGFBR2 had an increased prevalence of inflammatory bowel disease

19. ALK5 is an important mediator of HTFs fibrosis. ALK5 is a potential therapeutic target to suppress scar formation after filtration surgery.

20. PAR2 is crucial for TGF-beta1-induced cell motility by its ability to sustain expression of ALK5. Therapeutically targeting PAR2 may thus be a promising approach in preventing TGF-beta-dependent driven metastatic dissemination in PDAC and possibly other stroma-rich tumour types.

Pig (Porcine) Transforming Growth Factor, beta Receptor 1 (TGFBR1) interaction partners

1. miR-181a promoted porcine preadipocyte differentiation by directly targeting TGFBR1.

2. The results indicate that the TGFBR1 gene polymorphism (SNP64) is significantly associated with growth rates including average daily gains between birth and 56 kg, between 5.5 and 56 kg, between 35 and 56 kg.

3. Report temporal regulation of TGFBR1 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.

4. TGFbeta is abundant in boar seminal plasma, thus TGFbeta may be a male-female signalling agent involved in immune changes in the female reproductive tract elicited by seminal fluid.

5. Porcine transforming growth factor beta receptor 1 has many polymorphisms, including two nonsynonymous substitutions in exons 1 and 7 and novel alternative splicing in exon 3.

6. isolation and molecular characterization; the full-length TGFBR1 cDNA 1813 bp contains an open reading frame (ORF) of 1512 bp encoding a TGFBR1 protein of 503 amino acids with a calculated molecular weight of 56.4 kDa.

Cow (Bovine) Transforming Growth Factor, beta Receptor 1 (TGFBR1) interaction partners

1. found in binucleate cells of placenta

2. Results show that ALK5 and ALK1 play antagonistic roles in TGF-beta-induced podosome formation in aortic endothelial cells.

3. This study showed that ubiquitinated ALK5 and phosphorylated heat shock protein 27 specifically accumulate in the cytoskeleton fraction, and ALK1 and ALK5 interact with heat shock protein 90.

4. GM-CSF induced airway smooth muscle cells to increase expression of transforming growth factor (TGF)-beta receptors type I, II, and III, but had no detectable effect on the release of TGF-beta1 by the same ASMC; corticosteroids were inhibitory

5. ALK5 and Smad4 have roles in TGF-beta1-induced pulmonary endothelial permeability

6. These results indicate that high plasma cholesterol levels may contribute to the pathogenesis of certain diseases (e.g., atherosclerosis) by suppressing TGF-beta responsiveness.

7. Transforming growth factor-beta1 protects against pulmonary artery endothelial cell apoptosis via ALK5.

8. ALK1 and ALK5 are both essential for correct regulation of VEGF, and that disruption of either pathway leads to disease.

9. TGF-beta1 downregulates caveolin-1 of cultured endothelial cells, involving ALK-5 receptor subtype

Mouse (Murine) Transforming Growth Factor, beta Receptor 1 (TGFBR1) interaction partners

1. GPR50 is a TbetaRI co-receptor with potential impact on cancer development

2. TGFBR1 is a target gene of miR-22 during C2C12 myoblast differentiation.

3. Postnatal cartilage-specific deletion of Alk5 induced an OA-like phenotype with degradation of articular cartilage, synovial hyperplasia, osteophyte formation, subchondral sclerosis, as well as enhanced chondrocyte apoptosis, overproduction of catabolic factors, and decreased expressions of anabolic factors in chondrocytes. In addition, the expressions of PRG4 mRNA and protein were decreased in Alk5 conditional KO mice.

4. Loss of ALK5 is associated with germinal matrix hemorrhage-intraventricular hemorrhage.

5. this study shows that tissue-specific differentiation of colonic macrophages requires TGFbeta receptor-mediated signaling

6. Taken together, these results indicate that eIF6 may be involved in external mechanical force-mediated murine dermal fibroblast function at least partly through the TGF-beta1/TGFBR1/TGFBR2 pathway.

7. expression induced by IL-6 in keratinocytes

8. Loss of smooth muscle cell-Tgfbr1 triggers multiple deleterious pathways, including abnormal TGFBR2, ERK, and AngII/AT1R signals that disrupt aortic wall homeostasis to cause aortic aneurysm formation

9. miR-130a-3p might play a critical role in negatively regulating hepatic stellate cell activation and proliferation in the progression of nonalcoholic fibrosing steatohepatitis by directly targeting TGFBR1 and TGFBR2 via the TGF-beta/SMAD signaling pathway.

10. Deletion of smooth muscle cell-specific Tgfbr1 inhibits arterial neointimal hyperplasia in short term, but promotes an undesired vascular phenotype for injured arteries.

11. TGFbetaR1 signalling is needed for development of CD103(+)CD11b(+) intestinal DCs from CD103(-)CD11b(+) cells and that they contribute to the generation of Th17 and regulatory T cells.

12. Overactivation of TGFBR1 drives gonadal tumor development. The TGFBR1 constitutively active mouse model phenocopies a number of morphological, hormonal, and molecular features of human granulosa cell tumors and are potentially valuable for preclinical testing of targeted therapies to treat granulosa cell tumors, a class of poorly defined ovarian malignancies.

13. results indicate that CD34+ cells and signaling through ALK5 play pivotal roles in the morphogenesis of interstitial-like, peritubular-like and cord-like structures

14. a novel role for SREBP-1 as a cell surface retention factor for TbetaRI in mesangial cells, is reported.

15. a surface population of Hsp90 extracellularly binds TGFbetaRI and this complex behaves as an active participant in collagen production in TGFbeta-activated fibroblasts.

16. Conditional deletion of Tgfbr1 in PTEN-inactivated endometrium leads to a disease that recapitulates invasive and lethal human endometrial cancer.

17. fluid shear stress induces autocrine TGF-beta/ALK5-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1/2-mediated signaling.

18. both GDF-15 and TGF-beta1 counteract chemokine-induced integrin activation on neutrophils via the ALK-5/TGF-betaRII heterodimer.

19. CD109 differentially regulates TGF-beta-induced ALK1-Smad1/5 versus ALK5-Smad2/3 pathways, leading to decreased extracellular matrix production in the skin; epidermal CD109 expression regulates dermal function through a paracrine mechanism

20. miR-27b is an anti-fibrotic microRNA that inhibits fibroblast activation by targeting TGFbeta receptor 1 and SMAD2.