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Treatment of T. cruzi-infected cardiac spheroids with SB 431542, a selective inhibitor of TGF-b type I receptor, resulted in a reduction in the size of spheroids, which was accompanied by a decrease in parasite load and in fibronectin (show FN1 Proteins) expression.
TGFBR1/2 genetic variants (in particular when evaluated as a burden by score) might play a role in modulating the severity of cardiovascular manifestation in Marfan syndrome.
Inhibition of each TGFbeta (show TGFB1 Proteins) receptor-I, glucocorticoid receptor (show NR3C1 Proteins) or JNK (show MAPK8 Proteins) signaling partially reversed the dexamethasone-mediated effects, suggesting a complex signaling network. These data reveal that dexamethasone mediates progression by membrane effects and binding to glucocorticoid receptor (show NR3C1 Proteins)
DZNep induced miR (show MLXIP Proteins)-202-5p to target both TGFbeta (show TGFB1 Proteins) receptors, TGFBR1 and TGFBR2 (show TGFBR2 Proteins)...transfection of anti-miRNAs against miR (show MLXIP Proteins)-202-5p resulted in increased TGFBR1 and TGFBR2 (show TGFBR2 Proteins) protein expressions and induced EMT (show ITK Proteins) characteristics in these cells. In stellate pancreatic cells, miR (show MLXIP Proteins)-202 overexpression slowed growth as well as reduced stromal extracellular membrane matrix protein expression
Findings provide evidence that TGFBR-1 expression is regulated by SLC35F2 (show SLC35F2 Proteins) which exerts its oncogenic effect on papillary thyroid carcinoma progression through activation of TGFBR-1 and ASK-1 (show MAP3K5 Proteins).
miR (show MLXIP Proteins)-130a-3p might play a critical role in negatively regulating hepatic stellate cell activation and proliferation in the progression of nonalcoholic fibrosing steatohepatitis by directly targeting TGFBR1 and TGFBR2 (show TGFBR2 Proteins) via the TGF-beta (show TGFB1 Proteins)/SMAD (show SMAD1 Proteins) signaling pathway.
TGFbetaR1 signaling was involved in 14-3-3zeta (show YWHAZ Proteins)-mediated cell proliferation and metastasis of lung squamous cell carcinoma cells.
Mutational activation of BRAF (show BRAF Proteins) confers sensitivity to TGFBR1 inhibitors in human melanoma cells.
Loeys-Dietz syndrome patients with confirmed mutations in TGFBR1 or TGFBR2 (show TGFBR2 Proteins) had an increased prevalence of inflammatory bowel disease
ALK5 is an important mediator of HTFs fibrosis. ALK5 is a potential therapeutic target to suppress scar formation after filtration surgery.
The results indicate that the TGFBR1 gene polymorphism (SNP64) is significantly associated with growth rates including average daily gains between birth and 56 kg, between 5.5 and 56 kg, between 35 and 56 kg.
Report temporal regulation of TGFBR1 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
TGFbeta (show TGFB1 Proteins) is abundant in boar seminal plasma, thus TGFbeta (show TGFB1 Proteins) may be a male-female signalling agent involved in immune changes in the female reproductive tract elicited by seminal fluid.
Porcine transforming growth factor beta receptor 1 has many polymorphisms, including two nonsynonymous substitutions in exons 1 and 7 and novel alternative splicing in exon 3.
isolation and molecular characterization; the full-length TGFBR1 cDNA 1813 bp contains an open reading frame (ORF) of 1512 bp encoding a TGFBR1 protein of 503 amino acids with a calculated molecular weight of 56.4 kDa.
Results show that ALK5 and ALK1 (show ACVRL1 Proteins) play antagonistic roles in TGF-beta (show TGFB1 Proteins)-induced podosome formation in aortic endothelial cells.
This study showed that ubiquitinated ALK5 and phosphorylated heat shock protein 27 specifically accumulate in the cytoskeleton fraction, and ALK1 (show ACVRL1 Proteins) and ALK5 interact with heat shock protein 90 (show HSP90 Proteins).
GM-CSF (show CSF2 Proteins) induced airway smooth muscle cells to increase expression of transforming growth factor (TGF)-beta (show TGFB1 Proteins) receptors type I, II, and III, but had no detectable effect on the release of TGF-beta1 (show TGFB1 Proteins) by the same ASMC; corticosteroids were inhibitory
ALK5 and Smad4 (show SMAD4 Proteins) have roles in TGF-beta1 (show TGFB1 Proteins)-induced pulmonary endothelial permeability
These results indicate that high plasma cholesterol levels may contribute to the pathogenesis of certain diseases (e.g., atherosclerosis) by suppressing TGF-beta (show TGFB1 Proteins) responsiveness.
Transforming growth factor-beta1 protects against pulmonary artery endothelial cell apoptosis via ALK5.
ALK1 (show ACVRL1 Proteins) and ALK5 are both essential for correct regulation of VEGF (show VEGFA Proteins), and that disruption of either pathway leads to disease.
TGF-beta1 (show TGFB1 Proteins) downregulates caveolin-1 (show CAV1 Proteins) of cultured endothelial cells, involving ALK-5 receptor subtype
TGFBR1 is a target gene of miR (show MLXIP Proteins)-22 during C2C12 myoblast differentiation.
Postnatal cartilage-specific deletion of Alk5 induced an OA-like phenotype with degradation of articular cartilage, synovial hyperplasia, osteophyte formation, subchondral sclerosis, as well as enhanced chondrocyte apoptosis, overproduction of catabolic factors, and decreased expressions of anabolic factors in chondrocytes. In addition, the expressions of PRG4 mRNA and protein were decreased in Alk5 conditional KO mice.
Loss of ALK5 is associated with germinal matrix hemorrhage-intraventricular hemorrhage.
this study shows that tissue-specific differentiation of colonic macrophages requires TGFbeta (show TGFB1 Proteins) receptor-mediated signaling
Taken together, these results indicate that eIF6 (show EIF6 Proteins) may be involved in external mechanical force-mediated murine dermal fibroblast function at least partly through the TGF-beta1 (show TGFB1 Proteins)/TGFBR1/TGFBR2 (show TGFBR2 Proteins) pathway.
expression induced by IL-6 (show IL6 Proteins) in keratinocytes
Loss of smooth muscle cell-Tgfbr1 triggers multiple deleterious pathways, including abnormal TGFBR2 (show TGFBR2 Proteins), ERK (show EPHB2 Proteins), and AngII/AT1R (show AGTRAP Proteins) signals that disrupt aortic wall homeostasis to cause aortic aneurysm formation
Deletion of smooth muscle cell-specific Tgfbr1 inhibits arterial neointimal hyperplasia in short term, but promotes an undesired vascular phenotype for injured arteries.
TGFbetaR1 signalling is needed for development of CD103 (show ITGAE Proteins)(+)CD11b (show ITGAM Proteins)(+) intestinal DCs from CD103 (show ITGAE Proteins)(-)CD11b (show ITGAM Proteins)(+) cells and that they contribute to the generation of Th17 and regulatory T cells.
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.
TGF-beta receptor type I
, TGF-beta receptor type-1
, TGF-beta type I receptor
, activin A receptor type II-like kinase, 53kD
, activin A receptor type II-like kinase, 53kDa
, activin A receptor type II-like protein kinase of 53kD
, activin receptor-like kinase 5
, serine/threonine-protein kinase receptor R4
, transforming growth factor beta receptor I
, transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD)
, transforming growth factor-beta receptor type I
, transforming growth factor, beta receptor 1 (activin A receptor type II-like kinase, 53kDa)
, transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)
, transforming growth factor beta type I receptor
, transforming growth factor, beta receptor 1
, transforming growth factor beta receptor 1
, activin A receptor type II-like kinase
, transforming growth factor beta receptor type I
, transforming growth factor beta, receptor 1
, type I serine/threonine kinase receptor
, TGF-beta receptor type-1-like
, transforming growth factor, beta receptor I
, transforming growth factor, beta receptor 1 a
, transforming growth factor, beta receptor I a
, transforming growth factor-beta receptor type I a