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ALK5 is an important mediator of HTFs fibrosis. ALK5 is a potential therapeutic target to suppress scar formation after filtration surgery.
PAR2 (show F2RL1 Proteins) is crucial for TGF-beta1 (show TGFB1 Proteins)-induced cell motility by its ability to sustain expression of ALK5. Therapeutically targeting PAR2 (show F2RL1 Proteins) may thus be a promising approach in preventing TGF-beta (show TGFB1 Proteins)-dependent driven metastatic dissemination in PDAC and possibly other stroma-rich tumour types.
results suggest a role for prostatic expression of TGF-B, IL-1a (show IL1A Proteins), TGFBRI and TGFBRII as prognostic markers for prostate cancer. The rational combination of novel agents directed toward the inactivation of TGF-B, IL-1a (show IL1A Proteins), TGFBRI and TGFBRII could disrupt complementary tumor cell proliferation pathways.
Data show that twist-related protein 1 (Twist1 (show TWIST1 Proteins)) requires TGF-beta type-I receptor (TGFBR1)-activation for activation for epithelial-mesenchymal transition (EMT (show ITK Proteins))-induction.
This study shows that TFAP2C (show TFAP2C Proteins) promoted lung tumor progression by upregulation of TGFBR1 and consequent activation of PAK1 (show PAK1 Proteins) signaling.
combined inhibition of ALK5 and CTGF (show CTGF Proteins) is required to prevent TGFbeta (show TGFB1 Proteins)-induced nodule formation in tri (show VANGL2 Proteins)-cellular cultures
Aortic diseases in patients with TGFBR1 or TGFBR2 (show TGFBR2 Proteins) mutations show the same prevalence of systemic features and the same global survival.
Results show that TGFBR1 expression is regulated in bladder cancer cell through its desumoylation by SENP2.
Low TGFBR1 expression is associated with oral cancer progression.
TGF-beta (show TGFB1 Proteins) type I, II, and III receptors were all identified in pregnant serum; all were substantially elevated in early-onset but not late-onset preeclampsia. Endoglin (show ENG Proteins) was increased in both subtypes.
The results indicate that the TGFBR1 gene polymorphism (SNP64) is significantly associated with growth rates including average daily gains between birth and 56 kg, between 5.5 and 56 kg, between 35 and 56 kg.
Report temporal regulation of TGFBR1 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
TGFbeta (show TGFB1 Proteins) is abundant in boar seminal plasma, thus TGFbeta (show TGFB1 Proteins) may be a male-female signalling agent involved in immune changes in the female reproductive tract elicited by seminal fluid.
Porcine transforming growth factor beta receptor 1 has many polymorphisms, including two nonsynonymous substitutions in exons 1 and 7 and novel alternative splicing in exon 3.
isolation and molecular characterization; the full-length TGFBR1 cDNA 1813 bp contains an open reading frame (ORF) of 1512 bp encoding a TGFBR1 protein of 503 amino acids with a calculated molecular weight of 56.4 kDa.
Results show that ALK5 and ALK1 (show ACVRL1 Proteins) play antagonistic roles in TGF-beta (show TGFB1 Proteins)-induced podosome formation in aortic endothelial cells.
This study showed that ubiquitinated ALK5 and phosphorylated heat shock protein 27 specifically accumulate in the cytoskeleton fraction, and ALK1 (show ACVRL1 Proteins) and ALK5 interact with heat shock protein 90 (show HSP90 Proteins).
GM-CSF (show CSF2 Proteins) induced airway smooth muscle cells to increase expression of transforming growth factor (TGF)-beta (show TGFB1 Proteins) receptors type I, II, and III, but had no detectable effect on the release of TGF-beta1 (show TGFB1 Proteins) by the same ASMC; corticosteroids were inhibitory
ALK5 and Smad4 (show SMAD4 Proteins) have roles in TGF-beta1 (show TGFB1 Proteins)-induced pulmonary endothelial permeability
These results indicate that high plasma cholesterol levels may contribute to the pathogenesis of certain diseases (e.g., atherosclerosis) by suppressing TGF-beta (show TGFB1 Proteins) responsiveness.
Transforming growth factor-beta1 protects against pulmonary artery endothelial cell apoptosis via ALK5.
ALK1 and ALK5 are both essential for correct regulation of VEGF, and that disruption of either pathway leads to disease.
TGF-beta1 (show TGFB1 Proteins) downregulates caveolin-1 (show CAV1 Proteins) of cultured endothelial cells, involving ALK-5 receptor subtype
Deletion of smooth muscle cell-specific Tgfbr1 inhibits arterial neointimal hyperplasia in short term, but promotes an undesired vascular phenotype for injured arteries.
TGFbetaR1 signalling is needed for development of CD103 (show ITGAE Proteins)(+)CD11b (show ITGAM Proteins)(+) intestinal DCs from CD103 (show ITGAE Proteins)(-)CD11b (show ITGAM Proteins)(+) cells and that they contribute to the generation of Th17 and regulatory T cells.
Overactivation of TGFBR1 drives gonadal tumor development. The TGFBR1 constitutively active mouse model phenocopies a number of morphological, hormonal, and molecular features of human granulosa cell tumors and are potentially valuable for preclinical testing of targeted therapies to treat granulosa cell tumors, a class of poorly defined ovarian malignancies.
results indicate that CD34 (show CD34 Proteins)+ cells and signaling through ALK5 play pivotal roles in the morphogenesis of interstitial-like, peritubular-like and cord-like structures
a novel role for SREBP-1 (show SREBF1 Proteins) as a cell surface retention factor for TbetaRI in mesangial cells, is reported.
a surface population of Hsp90 (show HSP90 Proteins) extracellularly binds TGFbetaRI and this complex behaves as an active participant in collagen production in TGFbeta (show TGFB1 Proteins)-activated fibroblasts.
Conditional deletion of Tgfbr1 in PTEN-inactivated endometrium leads to a disease that recapitulates invasive and lethal human endometrial cancer.
fluid shear stress induces autocrine TGF-beta (show TGFB1 Proteins)/ALK5-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1 (show MAP2K1 Proteins)/2-mediated signaling.
both GDF-15 (show GDF15 Proteins) and TGF-beta1 (show TGFB1 Proteins) counteract chemokine (show CCL1 Proteins)-induced integrin activation on neutrophils via the ALK-5/TGF-betaRII heterodimer.
CD109 (show CD109 Proteins) differentially regulates TGF-beta (show TGFB1 Proteins)-induced ALK1 (show ACVRL1 Proteins)-Smad1 (show SMAD1 Proteins)/5 versus ALK5-Smad2 (show SMAD2 Proteins)/3 pathways, leading to decreased extracellular matrix production in the skin; epidermal CD109 (show CD109 Proteins) expression regulates dermal function through a paracrine mechanism
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.
TGF-beta receptor type I
, TGF-beta receptor type-1
, TGF-beta type I receptor
, activin A receptor type II-like kinase, 53kD
, activin A receptor type II-like kinase, 53kDa
, activin A receptor type II-like protein kinase of 53kD
, activin receptor-like kinase 5
, serine/threonine-protein kinase receptor R4
, transforming growth factor beta receptor I
, transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD)
, transforming growth factor-beta receptor type I
, transforming growth factor, beta receptor 1 (activin A receptor type II-like kinase, 53kDa)
, transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)
, transforming growth factor beta type I receptor
, transforming growth factor, beta receptor 1
, transforming growth factor beta receptor 1
, activin A receptor type II-like kinase
, transforming growth factor beta receptor type I
, transforming growth factor beta, receptor 1
, type I serine/threonine kinase receptor
, TGF-beta receptor type-1-like
, transforming growth factor, beta receptor I