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The phosphorylation of p53 (show TP53 Antibodies) by CK1 (show CSNK1A1 Antibodies) is an isoform-specific reaction to the K(221)RQK(224) loop.
CK1gamma1 phosphorylates p65 and consequently promotes its degradation by ubiquitin E3 ligases CUL2 and COMMD1.
casein kinase 1 gamma 1 phosphorylates claspin (show CLSPN Antibodies)
A 1756 bp cDNA encoded human protein kinase (show CDK7 Antibodies) CK1 (show CSNK1A1L Antibodies) (438 AA, mol (show DUOXA1 Antibodies) wt 50.272 Da, isoelectric point of 9.37) mapping to chromosome 15q22.
CK1 regulates fast synaptic transmission by glutamate (show GRIN1 Antibodies) in brain. Activation of CK1 decreases NMDA receptor activity in the striatum via activation by this kinase of protein phosphatase 1 (show PPP1CB Antibodies) &/or 2A & increased dephosphorylation of NMDA receptors.
This gene encodes a member of the casein kinase I gene family. The encoded protein is a serine/threonine kinase that phosphorylates acidic proteins, and participates in pathways for cell growth.
casein kinase 1, gamma 1
, casein kinase 1 gamma 2
, CKI-gamma 1
, casein kinase I isoform gamma-1
, casein kinase I, gamma 1