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The mechanism by which GLI1 loss of function sensitized tumor cells to vorinostat-induced apoptosis is at least in part through interactions with vorinostat to alter gene expression in a manner that favored apoptosis.
these findings propose that A3AR (show ADORA3 ELISA Kits) agonist induces cell cycle arrest and apoptosis in breast cancer stem cells by inhibition of ERK1/2 (show MAPK1/3 ELISA Kits) and GLI-1 cascade.
Gli1 could be a stem cell marker and an indicator of poor prognosis in patients with ductal breast carcinoma.
Expression of SHH (show SHH ELISA Kits) and GLI1 may be useful prognostic markers of Merkel cell carcinoma because increased expression was associated with better prognosis. Report high rate of silent mutations in GLI1 exon 5.
Results show that Gli1 and FoxM1 (show FOXM1 ELISA Kits) expression levels are consistently elevated in human colorectal cancer (CRC (show CALR ELISA Kits)) tissues. Moreover, Gli1 regulates the transcription of FoxM1 (show FOXM1 ELISA Kits) by directly binding to the promoter of FoxM1 (show FOXM1 ELISA Kits), which contributes to the proliferation of CRC (show CALR ELISA Kits) cells.
Results found that GLI1 expression is regulated by GAL1 (show LGALS1 ELISA Kits) in gastric cancer tissue specimen and cell lines.
Results indicated that GLI1 activation in TN-IBC as in TNBC, plays a vital role in promoting cell proliferation, motility, tumor growth, and formation of tumor emboli.
High gli1 expression is associated with Small Cell Lung Cancer.
This inhibitory effect on cell growth was partially rescued by exogenous KRT17 (show KRT17 ELISA Kits) expression. In the KRT17 (show KRT17 ELISA Kits)-positive regions in OSCCs, GLI-1 or GLI-2 (show GLI2 ELISA Kits) was frequently detected, and the number of cells with cleaved caspase-3 (show CASP3 ELISA Kits) positive was decreased. CONCLUSIONS: KRT17 (show KRT17 ELISA Kits) promotes tumor cell growth, at least partially, through its anti-apoptotic effect as a result of the KRT17 (show KRT17 ELISA Kits) overexpression by GLIs in OSCC
Results indicate that GLI1 is important for maintaining the invasive and mesenchymal-like properties of melanoma cells independent of MITF (show MITF ELISA Kits).
Data indicate that the expression levels of transcription factors Gli1 and Gli2 (show GLI2 ELISA Kits) in muscle were the lowest of the 13 tissues.
Dzip1-dependent stabilization of Spop (show SPOP ELISA Kits)/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway.
Zyxin (show ZYX ELISA Kits) inhibits Shh (show SHH ELISA Kits) signaling during the CNS patterning in Xenopus laevis through interaction with Gli1
Mutation of hmgcs1 (show HMGCS1 ELISA Kits) had no effect on Shh (show SHH ELISA Kits) signaling at 2 and 3 days post fertilization (dpf), but did result in a decrease in the expression of gli1, a known Shh (show SHH ELISA Kits) target gene, at 4 dpf, after morphological deficits in craniofacial development and chondrocyte differentiation were observed in hmgcs1 (show HMGCS1 ELISA Kits) mutants.
a new mechanism of Gli transcription factor activation and implicate ARHGAP36 (show ARHGAP36 ELISA Kits) dysregulation in the onset and/or progression of GLI-dependent cancers.
We show that Kif7 (show KIF7 ELISA Kits) interacts with both Gli1 and Gli2a and suggest that it functions to sequester Gli proteins in the cytoplasm, in a manner analogous to the regulation of Ci by Cos2 (show KIF7 ELISA Kits) in Drosophila.
Gli1 has a Hh-independent role in many motoneurons and V3 domain cells in embryos that lack Hh signalling, but removal of Gli1 activity does not affect more dorsal neurons.
These results reveal divergent requirements for Gli1 and Gli2 (show GLI2 ELISA Kits) in mouse and zebrafish and indicate that zebrafish Gli1 is an activator of Hh-regulated genes, while zebrafish Gli2 (show GLI2 ELISA Kits) has minor roles as a repressor or activator of Hh targets.
Gli1 regulates the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl (show SGPL1 ELISA Kits)) factor activity.
Shh (show SHH ELISA Kits) production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma
Gli1-expressing bone marrow cells are responsible for primary myelofibrosis in a transgenic mouse model.
USP21 (show USP21 ELISA Kits) recruits and stabilises Gli1 at the centrosome.
High Gli1 expression is associated with leukemia.
Sufu (show SUFUH ELISA Kits) is upregulated in active Shh (show SHH ELISA Kits) responding tissues and accompanies Gli activators translocating into and Gli repressors out of the nucleus.
Gli1 and Gli2 exhibited different functions in the regulation of p63 expression or proliferation of p63(+) cells in Kras-AR driven tumors.
NANOG (show NANOG ELISA Kits) binds to GLI1 and GLI3 (show GLI3 ELISA Kits) proteins and represses Hedgehog (show SHH ELISA Kits)-mediated transcription.
characterization of the contribution to remyelination of a subset of adult neural stem cells, identified by their expression of Gli1, a transcriptional effector of the sonic hedgehog (show SHH ELISA Kits) pathway
the three GLI factors(GLI1, GLI2 (show GLI2 ELISA Kits), and GLI3 (show GLI3 ELISA Kits)) in mature hepatocytes form an interactive transcriptional network that is involved in the control of target genes associated with metabolic zonation as well as with lipid and drug metabolism
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.
glioma-associated oncogene 1
, glioma-associated oncogene homolog 1 (zinc finger protein)
, oncogene GLI
, zinc finger protein GLI1
, GLI-Kruppel family member GLI1
, GLI family zinc finger 1, gene 1
, zinc finger DNA binding protein Gli-1
, glioma-associated oncogene homolog
, zinc finger protein 5