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anti-Human OAS2 Antibodies:
anti-Mouse (Murine) OAS2 Antibodies:
anti-Rat (Rattus) OAS2 Antibodies:
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Epigenetic regulation of OAS2 shows disease-specific DNA methylation (show HELLS Antibodies) profiles at individual CpG sites.
we characterized the functional consequences of the Neandertal haplotype in the transcriptional regulation of OAS (show SMOC1 Antibodies) genes at baseline and infected conditions. We found that cells from people with the Neandertal-like haplotype express lower levels of OAS3 (show OAS3 Antibodies) upon infection, as well as distinct isoforms of OAS1 (show OAS1 Antibodies) and OAS2
Suggest 2'5'-oligoadenylate synthetase 2 mediates T-cell receptor CD3-zeta (show CD247 Antibodies) chain down-regulation via caspase-3 (show CASP3 Antibodies) activation in oral cancer.
Data obtained suggest that the OAS2 rs1293762 and CD209 (show CD209 Antibodies) rs2287886 SNPs are associated with predisposition to chronic hepatitis C in Russian population.
Primary mononuclear cells from patients with systemic sclerosis have increased basal levels of OASL (show OASL Antibodies) and OAS2 genes.
The results suggest that OAS1 (show OAS1 Antibodies)-OAS3 (show OAS3 Antibodies)-OAS2 haplotypes are associated with differential susceptibility to clinical outcomes of dengue infection.
The data suggest a possible association between OAS2 and OAS3 (show OAS3 Antibodies) single nucleotide polymorphisms and the outcome of tick-borne encephalitis virus infection in a Russian population.
2'-5'-oligoadenylate synthetase type 2 (OAS2), a dsRNA binding protein involved in the pathway that activates RNase-L (show RNASEL Antibodies), is identified as a new binding partner for NOD2 (show NOD2 Antibodies).
A non-synonymous mutation in Oas2 (I405N) in the viral sensor Oas2 was found and the mutation caused post-partum failure of lactation in healthy mice with otherwise normally developed mammary glands, characterized by greatly reduced milk protein synthesis coupled with epithelial cell death, inhibition of proliferation and a robust interferon (show IFNA Antibodies) response. The mutation activates the OAS2 pathway.
Endogenous expression of the porcine OAS2 gene could be promoted by interferon (show IFNA Antibodies) (IFN)-beta (show IFNB1 Antibodies) or PRRSV infection in porcine alveolar macrophages. Knockdown of porcine OAS2 led to increases in PRRSV replication, and OAS2 expression suppressed replication of PRRSV in a retinoic acid inducible gene I (RIG-I (show DDX58 Antibodies))-dependent manner, anti-PRRSV activity of porcine OAS2 would be lost if RNase L (show RNASEL Antibodies) and OAS2 were both silenced.
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.
(2'-5')oligo(A) synthetase 2
, 2'-5'-oligoadenylate synthase 2
, 2-5A synthase 2
, p69 OAS / p71 OAS
, (2-5')oligo(A) synthase 2
, 2',5'-oligoadenylate synthetase-like 11
, 2'-5' oligoadenylate synthetase-like 11
, 2,5-oligoadenylate synthetase-like 11
, 2'-5'-oligoadenylate synthetase 2, 69/71kDa
, 2'-5' oligoadenylate synthetase 2
, 2',5'-oligoadenylate synthetase 2
, 2'-5'-oligoadenylate synthetase 2-like
, 2'-5'-oligoadenylate synthase 2-like