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Human IGF2 Protein expressed in Escherichia coli (E. coli) - ABIN413415
Wang, Rayes, Elahi, Lu, Hancock, Massie, Rowe, Aomari, Hossain, Durocher, Pinard, Tabariès, Siegel, Brodt: The IGF-Trap: Novel Inhibitor of Carcinoma Growth and Metastasis. in Molecular cancer therapeutics 2015
Results showed that IGF-2 was persistently expressed in oculomotor neurons in health and amyotrophic lateral sclerosis (ALS) and thus could play a role in oculomotor resistance in this disease.
Studies indicate that miR (show MLXIP Proteins)-663b is epigenetically repressed by long non-coding RNA HOTAIR and exerts its tumor-suppressive function via targeting insulin-like growth factor 2 (IGF2) in pancreatic cancer.
IGF-II-mediated loss of E-cadherin (show CDH1 Proteins) is central in developing hepatomegaly in mice and abnormal cell growth in the hepatoma cell line
Aberrant IGF2 imprinting may be an intrinsic epigenetic control mechanism that enhances stemness, self-renewal and chemo/radiotherapy resistance in cancer stem cells.
DNMT1 (show DNMT1 Proteins)-mediated transcriptional upregulation of IGF2 is a novel mechanism of resistance to HDIs, highlighting the role of epigenetic deregulation of IGF2 in HDI resistance and the potential value of the H19 (show NCKAP1 Proteins)/IGF2 ICR hypermethylation and DNMT1 (show DNMT1 Proteins) expression as predictive biomarkers in HDI-based anticancer therapies.
Human H19/Igf2 imprinting control regions can functionally replace mouse H19/Igf2 imprinting control regions on the maternal allele.
IGF2 gene overexpression in a series of children diagnosed with adrenocortical tumors was not related to any clinical or biological features analyzed here, while IGF1R (show IGF1R Proteins) gene expression was significantly higher in children who presented tumor relapse and metastasis, which was not true for the IGF1R (show IGF1R Proteins) protein expression analyzed by immunohistochemistry. IGF1R (show IGF1R Proteins) overexpression could be indicative of aggressive ACTs in children.
IGF2 may exert its oncofunction, at least partly, through its parasitic miR-483 which suppressed DLC-1 in colorectal cancer cells.
We report here the first deletions of ICR1 associated with hypomethylation of the IGF2/H19 (show NCKAP1 Proteins) domain leading to SRS (show SMS Proteins).
Methylation patterns of IGF2 regulatory regions can discriminate adrenocortical carcinomas from adrenocortical adenomas with high diagnostic accuracy.
ith respect to the different IGFs produced locally, a decrease in igf1a (show IGF1 Proteins) expression and a significant increase in both igf2a and igf2b expression was observed, suggesting that igf1a (show IGF1 Proteins) is not directly involved in fin regeneration. Overall, the results revealed that excess GH enhances fin regeneration in zebrafish through igf2a and igf2b expression, acting indirectly on this major physiological process.
Igf2 regulates early neural and cardiovascular development in zebrafish embryos.
The IGF2 expression has also been reported at earlier stages in fish.
zebrafish orthologs of IGF2 function in dorsal midline development during segmentation/neurulation, whereas one paralog, igf2b, has evolved additional, distinct functions during subsequent organogenesis.
IGF2 is silenced in mouse embryos by the zinc finger protein ZFP568
Loss of imprinting at the Igf2/H19 (show NCKAP1 Proteins) locus disrupts in vitro differentiation of primary myoblasts.
Epithelial IGF1R is dispensable for IGF2-mediated enhanced intestinal adaptation after small bowel resection in retinoblastoma-deficient mice.
These findings indicate that IGF-II reduces PGC-1alpha expression in skeletal muscle cells through a mechanism involving PI3K-Akt (show AKT1 Proteins)-FoxO1 (show FOXO1 Proteins) but not p38 MAPK (show MAPK14 Proteins) or Erk1/2 MAPK (show MAPK1 Proteins) pathways.
Here the authors show that fibroblast growth factor 22 (FGF22 (show FGF22 Proteins)), a target-derived presynaptic organizer in the mouse hippocampus, induces the expression of insulin-like growth factor 2 (IGF2) for the stabilization of presynaptic terminals.
Loss of Igf2 Gene Imprinting is associated with Prostate Cancer.
IGF2 controls bone growth by regulating glucose metabolism in chondrocytes.
These results demonstrate that overexpressed IGF-2 is the major tumorigenic driver in a subset of CRCs and encourage testing of MEDI-573, alone and in combinations, in IGF2-overexpressing CRC patients.
results demonstrate that the H19 (show NCKAP1 Proteins)-Igf2 axis is negatively regulated by CTCF (show CTCF Proteins)-PHB1 (show PHB Proteins) cooperation and that H19 (show NCKAP1 Proteins) is involved in modulating the growth-suppressive effect of PHB1 (show PHB Proteins) in the liver.
trans-associations occur between three imprinted genes IGF2, DLK1 and MEG3 both in fetal liver and muscle cells.
A single nucleotide polymorphism in a regulatory region of intron 3 within the porcine IGF2 gene is associated with increased lean deposition and decreased fat deposition in pigs with paternal A alleles compared with pigs with paternal G alleles.
These findings indicated that the mRNA of H19 (show NCKAP1 Proteins) and IGF2 genes is susceptible to in vitro environments during the process of ES cell derivation from blastocysts but DNA methylation (show HELLS Proteins) status at this region was well maintained.
study did not find any significant associations for polymorphisms in insulin (show INS Proteins)-like grwoth factor 2, GTP Binding Protein (show RND1 Proteins) alpha Subunits, Gs and melanocortin receptor 4 (show MC4R Proteins) genes with reproductive traits of Polish Landrace and Large White pigs
The results suggested that IFG (show IFNG Proteins)-1 and -2 and their receptors are differentially expressed at the maternal and fetal components of the attachment site.
Genetic variation in the promoter region of the IGF2 gene is associated with intramuscular fat content in porcine skeletal muscle.
The IGF2 G allele has strong adipogenic effects at the subcutaneous adipose tissue level and enhances the intermuscular fat content in ham.
IGF-I (show IGF1 Proteins), IGF-II, and IGFBP-3 (show IGFBP3 Proteins) mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
The imprinting status in adult liver, muscle and kidney tissues were also not reflected in the methylation patterns of IGF2 DMRs 1 and 2.
The expression of IGF-I and IGF-II in native growth plates of prepubertal piglets and under different cell culture conditions, was compared.
Methylation pattern in a CpG island of the IGF2 gene in cumulus cells from 1-3 mm and >/= 8.0 mm follicles and the effects of in vitro maturation on this pattern.
Our results provide evidence that polymorphisms in the IGF2 gene are associated with growth traits, and may be used for marker-assisted selection in beef cattle breeding program
The identification of the polymorphisms in the IGF2 gene that were significantly associated with growth traits in cattle.
Polymorphisms in the IGF2 gene are associated with cattle growth traits.
The LEP (show LEP Proteins), IGF2 and CCL2 (show CCL2 Proteins) genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.
Sex-sorting procedure by flow cytometry did not affect the overall DNA methylation (show HELLS Proteins) patterns of the IGF2 and IGF2R (show IGF2R Proteins) genes, although individual variation in their methylation patterns among bulls was observed.
The reduction in IGFs mRNA level after 5 days of life in the duodenum (IGF-1 (show IGF1 Proteins) and IGF-2) and in the jejunum (IGF-1 (show IGF1 Proteins)) was associated with reduction in villi length (duodenum and jejunum) and the increase of crypt depth (duodenum).
Changes in the methylation pattern of IGF2 during in vitro maturation were different between incompetent and competent oocytes, and this characteristic may be useful as a molecular marker in studies of oocyte competence in cattle.
Data describes the long-term changes to skeletal muscle growth and IGF1 (show IGF1 Proteins), 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.
findings support work which suggests that the insulin-like growth factor 2 locus is an important biological regulator of milk production in dairy cattle
increased endogenous IGF1 (show IGF1 Proteins) and IGF2 expression by the blastocyst compensates for the loss of systemic insulin (show INS Proteins) and IGF.
Data suggest that metabolism of IGF1 (show IGF1 Proteins), IGF2, and IGFBP3 (insulin-like growth factor binding protein-3 (show IGFBP3 Proteins)) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
Methylation of three selected CpG islands of promoter of equine IGF2 gene was comparable between young and old horses, suggesting that aging could not be considered as a factor modulating methylation status of selected CpG islands within equine IGF2 gene.
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
insulin-like growth factor II
, insulin-like growth factor type 2
, insulin-like growth factor 2
, insulin-like growth factor 2b
, insulin-like growth factor 2-A
, insulin-like growth factor II-A
, multiplication-stimulating polypeptide
, Insulin-like growth factor II (somatomedin A)
, insulin-like growth factor II (IGF-II)
, insulin-like growth factor II isoform 2 variant 4 preprotein
, multiplication-stimulating activity
, insulin growth factor 2
, insulin-like growth factor-II
, prepro-insulin-like growth factor-II
, Insulin-like growth factor 2-B
, insulin-like growth factor 2 (somatomedin A)
, insulin-like growth factor 2-B
, insulin-like growth factor II-B
, Insulin-like growth factor II-B