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In plants, Dol-P-Man is synthesized when Dol-P-Man synthase1 (DPMS1), the catalytic core, interacts with two binding proteins, DPMS2 and DPMS3, that may serve as membrane anchors for DPMS1 or provide catalytic assistance.
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex.
dolichol-phosphate mannosyltransferase subunit 3
, dolichyl-phosphate mannosyltransferase polypeptide 3
, prostin 1
, DPM synthase complex subunit 3
, MPD synthase subunit 3
, dolichol-phosphate mannose synthase subunit 3
, dolichyl-phosphate beta-D-mannosyltransferase subunit 3
, mannose-P-dolichol synthase subunit 3