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anti-Human MBOAT7 Antibodies:
anti-Mouse (Murine) MBOAT7 Antibodies:
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Dog (Canine) Polyclonal MBOAT7 Primary Antibody for WB - ABIN2783918
Blanchard, Taha, Cheon, Kim, Turk, Rapoport: iPLA2β knockout mouse, a genetic model for progressive human motor disorders, develops age-related neuropathology. in Neurochemical research 2014
Human Polyclonal MBOAT7 Primary Antibody for WB - ABIN4231381
Robichaud, Boulay, Munganyiki, Surette: Fatty acid remodeling in cellular glycerophospholipids following the activation of human T cells. in Journal of lipid research 2013
Data imply an upregulated expression of PTGER4 and PSCA as well as a downregulated expression of MBOAT7 in gastric tissue as risk-conferring gastric cancer patho-mechanisms.
the variant MBOAT7 rs641738 genotype is not associated with spontaneous clearance of HBV and HCV infections or with the progression of liver disease in chronic hepatitis B or C in a genetic context of Mediterranean patients
The MBOAT7 rs641738 variant influences alanine transaminase levels and exerts an additive effect with patatin-like phospholipase domain-containing 3 and transmembrane 6 superfamily member2 variants on nonalcoholic fatty liver disease risk in obese children.
This study explored the role of rs641738 C/T located in TMC4 exon 1 (p.Gly17Glu) and 500 bases- downstream of MBOAT7 gene (TMC4/MBOAT7), in the genetic risk for developing nonalcoholic fatty liver disease (NAFLD). No evidence was found of association between rs641738 and either NAFLD. Low levels of MBOAT7 protein expression were found in the liver of patients with NAFLD, which were unrelated to the rs641738 genotypes.
Carriage of TM6SF2 rs58542926 is an additional risk factor for the development of hepatocellular carcinoma (HCC) in people with alcohol-related cirrhosis. Carriage of both PNPLA3 rs738409 and TM6SF2 rs58542926 accounts for half of the attributable risk for HCC in this population. The risk associated with carriage of MBOAT7 rs641738 was not significant.
Results show that MBOAT7 rs641738 is not linked to hepatic fibrosis, alcohol or hepatitis C virus induced liver cirrhosis in an Eastern European population.
The rs626283 variant in the MBOAT7 gene is associated with NAFLD and may affect glucose metabolism by modulating intra-hepatic fat content in Caucasian obese children and adolescents.
Variants with moderate effect size in MBOAT7 have been shown to have a significant contribution to the Non-alcoholic fatty liver disease development.
The variant MBOAT7 rs641738 genotype is not associated with hepatic steatosis and serum levels of CK-18 fragment in obese Taiwanese children.
the MBOAT7 rs641738 T allele is associated with reduced MBOAT7 expression and may predispose to HCC in European individuals without cirrhosis, suggesting it should be evaluated in future prospective studies aimed at stratifying NAFLD-HCC risk.
rs641738 polymorphism is a novel risk variant for liver inflammation in hepatitis C, and thereby for liver fibrosis
Children carrying the T allele of the MBOAT7 polymorphism had higher plasma alanine aminotransferase than the noncarriers; children with the MBOAT7, PNPLA3, and TM6SF2 variants had the highest plasma ALT
MBOAT7 polymorphism contributes to hepatic inflammation and liver fibrosis in patients with chronic hepatitis B.
Fibrosis stages were affected by the PNPLA3 (P = 0.042) and MBOAT7 (P = 0.021) but not by the TM6SF2 polymorphism (P > 0.05). The PNPLA3, TM6SF2, and MBOAT7 variants are associated with increased liver injury. The TM6SF2 variant seems to modulate predominantly hepatic fat accumulation, whereas the MBOAT7 polymorphism is linked to fibrosis. The PNPLA3 polymorphism confers risk of both increased steatosis and fibrosis
identification of six consanguineous families harboring homozygous inactivating variants in MBOAT7, encoding lysophosphatidylinositol acyltransferase (LPIAT1); subjects presented with intellectual disability frequently accompanied by epilepsy and autistic features
Report an association between the MBOAT7 rs641738 variant and the development and severity of NAFLD in individuals of European descent.
Variants in the MBOAT7 gene is associated with alcohol-related cirrhosis.
ssSPTa is identified as an LPIAT1-interacting protein.
MBOAT5 and MBOAT7 in arachidonate recycling, thus regulating free arachidonic acid levels and leukotriene synthesis in neutrophils
reviews members of the MBOAT family
LPIAT1-deficient RAW264.7 cells showed prolonged oscillations of intracellular calcium.
These results suggest that LPEAT1/MBOAT1 plays an important role in neurite outgrowth and function.
LPIAT1 has an essential role in maintaining physiological levels of PtdIns and PtdInsP(2) in the mouse
Data show that lysophosphatidylinositol acyltransferase 1 (LPIAT1, also known as MBOAT7) plays a crucial role in brain development in mice.
Congenital hydrocephalus in Mboat 7 null mice
Knockdown of class III PI 3-kinase causes growth defects in mboa-7 mutants.
mboa-7 encodes a member of the membrane-bound O-acyltransferase family, suggesting that mboa-7 is lysoPI acyltransferase.
This gene encodes a member of the membrane-bound O-acyltransferases family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the reacylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle. Alternative splicing results in multiple transcript variants.
, LPLAT 7
, bladder and breast carcinoma-overexpressed gene 1 protein
, leukocyte receptor cluster (LRC) member 4
, lyso-PI acyltransferase
, lysophosphatidylinositol acyltransferase
, lysophospholipid acyltransferase 7
, malignant cell expression-enhanced gene/tumor progression-enhanced
, O-acyltransferase domain-containing protein 7
, leukocyte receptor cluster member 4
, membrane-bound O-acyltransferase domain-containing protein 7