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Blockade of IQGAP1 (show IQGAP1 Proteins) interaction with PIPKIalpha or PI(3 (show PI3 Proteins))K inhibited PtdIns(3,4,5)P3 generation and signalling, and selectively diminished cancer cell survival.
The results showed that, in contrast to the enteroviruses and the cardioviruses, foot-and-mouth disease virus replication does not require PI4KIII (PI4KIIIalpha and PI4KIIIbeta (show PI4KB Proteins)), and phosphatidylinositol 4-phosphate levels do not increase in foot-and-mouth disease virus-infected cells and phosphatidylinositol 4-phosphate is not seen at replication organelles.
Missense mutations in PI4KA are associated with perisylvian polymicrogyria, cerebellar hypoplasia and arthrogryposis.
PI4KA and GRM3 (show GRM3 Proteins) polymorphisms have potential to jointly modulate antipsychotic response
PI4KA mRNA could be used as a new molecular marker to improve established prognostic models for hepatocellular carcinoma.
Descriptive Statement The genetic interactions associated with ILVatrophy rate in this study may be mapping variants inSYNJ2andPI4KAthat interact to decrease synthesisof PIP (show PIP Proteins).
PI4KA is essential for the maintenance of plasma membrane phosphatidylinositol 4,5-bisphosphate pools but only during strong stimulation of receptors coupled to phospholipase C (show PLC Proteins) activation.
Cell culture studies with Phosphatidylinositol-4-kinase IIIalpha inhibitors demonstrated that the kinase activity was essential for hepatitis C virus RNA replication.
Phosphatidylinositol 4-kinase IIalpha is palmitoylated by Golgi-localized palmitoyltransferases in cholesterol-dependent manner
PI4KA is necessary for the local enrichment of PI 4-phosphate at the hepatitis c virus membranous web.
Loss of phosphatidylinositol 4-kinase (show PI4KB Proteins) 2alpha activity causes late onset degeneration of spinal cord axons.
This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Two transcript variants encoding different isoforms have been described for this gene.
, phosphatidylinositol 4-kinase 230
, phosphatidylinositol 4-kinase alpha
, phosphatidylinositol 4-kinase, type III, alpha
, ptdIns-4-kinase alpha
, phosphatidylinositol 4-kinase type 3 alpha
, phosphatidylinositol 4-kinase, catalytic, alpha polypeptide
, leuserpin 2
, phosphatidylinositol 4-kinase a
, phosphatidylinositol 4-kinase, catalytic, alpha
, LOW QUALITY PROTEIN: phosphatidylinositol 4-kinase alpha