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Full name:: Phosphatidylinositol 4-Kinase, Catalytic, alpha Proteins (PI4KA)

On www.antibodies-online.com are 4 Phosphatidylinositol 4-Kinase, Catalytic, alpha (PI4KA) Proteins from 3 different suppliers available. Additionally we are shipping PI4KA Kits (15) and PI4KA Antibodies (11) and many more products for this protein. A total of 30 PI4KA products are currently listed.

Synonyms:: PI4-kinase alpha, PI4K-alpha, pi4K230, pi4ka, pik4ca, PtdIns-4-kinase alpha, zgc:172062

list all proteins	Gene Name	GeneID	UniProt
	PI4KA	5297	P42356
Rat PI4KA	PI4KA	64161
Mouse PI4KA	PI4KA	224020	E9Q3L2
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PI4KA Proteins (PI4KA) by Origin

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Relevant Pathways for PI4KA Proteins

Inositol Metabolic Process

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Human Phosphatidylinositol 4-Kinase, Catalytic, alpha (PI4KA) interaction partners

Blockade of IQGAP1 (show IQGAP1 Proteins) interaction with PIPKIalpha or PI(3 (show PI3 Proteins))K inhibited PtdIns(3,4,5)P3 generation and signalling, and selectively diminished cancer cell survival.
The results showed that, in contrast to the enteroviruses and the cardioviruses, foot-and-mouth disease virus replication does not require PI4KIII (PI4KIIIalpha and PI4KIIIbeta (show PI4KB Proteins)), and phosphatidylinositol 4-phosphate levels do not increase in foot-and-mouth disease virus-infected cells and phosphatidylinositol 4-phosphate is not seen at replication organelles.
Missense mutations in PI4KA are associated with perisylvian polymicrogyria, cerebellar hypoplasia and arthrogryposis.
PI4KA and GRM3 (show GRM3 Proteins) polymorphisms have potential to jointly modulate antipsychotic response
PI4KA mRNA could be used as a new molecular marker to improve established prognostic models for hepatocellular carcinoma.
Descriptive Statement The genetic interactions associated with ILVatrophy rate in this study may be mapping variants inSYNJ2andPI4KAthat interact to decrease synthesisof PIP (show PIP Proteins).
PI4KA is essential for the maintenance of plasma membrane phosphatidylinositol 4,5-bisphosphate pools but only during strong stimulation of receptors coupled to phospholipase C (show PLC Proteins) activation.
Cell culture studies with Phosphatidylinositol-4-kinase IIIalpha inhibitors demonstrated that the kinase activity was essential for hepatitis C virus RNA replication.
Phosphatidylinositol 4-kinase IIalpha is palmitoylated by Golgi-localized palmitoyltransferases in cholesterol-dependent manner
PI4KA is necessary for the local enrichment of PI 4-phosphate at the hepatitis c virus membranous web.

Mouse (Murine) Phosphatidylinositol 4-Kinase, Catalytic, alpha (PI4KA) interaction partners

PI4KA is essential for the maintenance of plasma membrane phosphatidylinositol 4,5-bisphosphate pools but only during strong stimulation of receptors coupled to phospholipase C (show PLC Proteins) activation.
Loss of phosphatidylinositol 4-kinase (show PI4KB Proteins) 2alpha activity causes late onset degeneration of spinal cord axons.

PI4KA Protein Profile

Protein Summary

This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Two transcript variants encoding different isoforms have been described for this gene.

Alternative names and synonyms associated with PI4KA

phosphatidylinositol 4-kinase alpha (PI4KA)
phosphatidylinositol 4-kinase alpha (Pi4ka)
phosphatidylinositol 4-kinase, catalytic, alpha b (pi4kab)
phosphatidylinositol 4-kinase, catalytic, alpha S homeolog (pi4ka.S)

PI4-kinase alpha protein
PI4K-alpha protein
pi4K230 protein
pi4ka protein
pik4ca protein
PtdIns-4-kinase alpha protein
zgc:172062 protein

Protein level used designations for PI4KA

PI4-kinase alpha , phosphatidylinositol 4-kinase 230 , phosphatidylinositol 4-kinase alpha , phosphatidylinositol 4-kinase, type III, alpha , ptdIns-4-kinase alpha , PI4K-alpha , phosphatidylinositol 4-kinase type 3 alpha , phosphatidylinositol 4-kinase, catalytic, alpha polypeptide , leuserpin 2 , phosphatidylinositol 4-kinase a , phosphatidylinositol 4-kinase, catalytic, alpha , LOW QUALITY PROTEIN: phosphatidylinositol 4-kinase alpha

GENE ID	SPECIES
5297	Homo sapiens
282309	Bos taurus
64161	Rattus norvegicus
416767	Gallus gallus
101117020	Ovis aries
224020	Mus musculus
793349	Danio rerio
446720	Xenopus laevis
100343247	Oryctolagus cuniculus
100157143	Sus scrofa
486443	Canis lupus familiaris

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