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anti-Human PIP4K2A Antibodies:
anti-Mouse (Murine) PIP4K2A Antibodies:
anti-Rat (Rattus) PIP4K2A Antibodies:
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Human Polyclonal PIP4K2A Primary Antibody for IHC (p), WB - ABIN392598
Wilcox, Hinchliffe: Regulation of extranuclear PtdIns5P production by phosphatidylinositol phosphate 4-kinase 2alpha. in FEBS letters 2008
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Human Polyclonal PIP4K2A Primary Antibody for IHC (p), ELISA - ABIN544192
Loijens, Boronenkov, Parker, Anderson: The phosphatidylinositol 4-phosphate 5-kinase family. in Advances in enzyme regulation 1996
Show all 3 Pubmed References
Human Polyclonal PIP4K2A Primary Antibody for IHC (p), ELISA - ABIN543096
Boronenkov, Anderson: The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinases. in The Journal of biological chemistry 1995
Show all 3 Pubmed References
Fine-mapping at chromosome 10p12 identified rs4748812 variant in PIP4K2A which alters a RUNX1 binding motif and demonstrated chromosomal looping to the PIP4K2A promoter. This variant was found associated with childhood acute lymphoblastic leukemia.
Recombinant PIP4K2A has the RNA binding activity and can associate specifically with Plasmodium 3'UTR RNAs.
the rs7088318 (PIP4K2A) and rs2239633 (CEBPE) polymorphisms were not associated with ALL risk.
meta-analysis of association of SNPs rs7088318 and rs4748793 and acute lymphoblastic leukemia susceptibility
PIP5K2A is possibly involved in a mechanism protecting against tardive dyskinesia-inducing neurotoxicity.
The diplotype ATTGCT/ATTGCT of the PIP4K2A gene confers approximately three-times higher incomplete responsiveness towards antipsychotics in severely ill patients.
PIP4K2A to be essential for the clonogenic and leukemia-initiating potential of human AML cells, and for the clonogenic potential of murine MLL-AF9 AML cells.
We also showed that PIPKIIalpha silencing can induce alpha and gamma globin expression and decrease cell proliferation in K562 cells.
Overexpression of type 2A PI(4)P5-kinase (PIP5K 2A) significantly reduced tamoxifen inhibition of Kv7.2/Kv7.3 and Kv7.2 R463Q channels.
The data suggest that PI5P4Ka N251S does not significantly differ in activity from the wild-type enzyme, throwing a new light on its association with schizophrenia.
Knocking down PI5P4Kalpha and beta in a breast cancer cell line bearing an amplification of the gene encoding PI5P4K beta and deficient for p53 impaired growth on plastic and in xenografts.
Variation at 10p12.2 (PIP4K2A) and 10p14 (GATA3) influences risk of acute lymphoblastic anemia and tumor subtype. (Meta-analysis)
PIP5K2A variant influences susceptibility to schizophrenia in the Russian population of Siberia. Authors studied 355 patients with schizophrenic disorders from the Russian population of Siberia.
The present study demonstrated that expression of PIP4K2A mRNA is significantly increased in LCL derived from patients with schizophrenia
Studies indicate that the gene PIP5K2A was significantly elevated in stroma cells in distant metastasis group, compared to stroma in no distant metastasis group.
PIP4Kbeta interacts with and modulates nuclear localization of the PIP4Kalpha.
A homogeneous sample of 280 schizophrenia patients and 230 healthy controls of Hungarian, Caucasian descent were genotyped for polymorphisms in schizophrenia candidate genes NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A.
study supports a minor role for PIP4K2A in schizophrenia etiology in the Irish population
PIP5K2A is a novel signaling element in the regulation of EAAT3 activity
translocation by protein kinase C is required for platelet alpha-granule secretion
Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family.
1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha
, 1-phosphatidylinositol-4-phosphate kinase
, 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha
, PI(5)P 4-kinase type II alpha
, PtdIns(4)P-5-kinase B isoform
, diphosphoinositide kinase 2-alpha
, phosphatidylinositol 5-phosphate 4-kinase type II alpha
, phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
, phosphatidylinositol-4-phosphate 5-kinase, type II, alpha
, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha
, ptdIns(4)P-5-kinase C isoform
, ptdIns(5)P-4-kinase isoform 2-alpha
, type II phosphatidylinositol-4-phosphate 5-kinase 53 K isoform
, 1-phosphatidylinositol-5-phosphate 4-kinase A
, PIPK2 alpha
, phosphatidylinositol-4-phosphate 5-kinase type II alpha
, phosphatidylinositol-5-phosphate 4-kinase type II alpha
, phosphatidylinositol-5-phosphate 4-kinase, type II, alpha, genome duplicate a