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These studies indicate a functional negative correlation between elevated levels of PIP5KL1 and the development of human gastric cancer.
PIPKH acts as a scaffold to localize and regulate type I PI(4)P 5-kinases and the synthesis of PI(3,4,5)P(3)
PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs (see PIP5K1A\; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004
PI(4)P 5-kinase-like protein 1
, phosphatidylinositol 4-phosphate 5-kinase-like protein 1
, phosphatidylinositol phosphate kinase homolog
, phosphatidylinositol-4-phosphate 5-kinase-like protein 1
, ptdIns(4)P-5-kinase-like protein 1