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results suggested that IFN-gamma (show IFNG Proteins) induces autophagy-associated apoptosis in CRC (show CALR Proteins) cells via inducing cPLA2-dependent mitochondrial ROS (show ROS1 Proteins) production.
These findings indicate the positive roles of cPLA2alpha in breast cancer cell growth, survival, migration and response to chemotherapy. Our work also highlights the therapeutic value of blocking cPLA2alpha to overcome chemoresistance in breast cancer.
These results indicate epigenetic regulation of cPLA2 and the potential of such regulation for treatment of chronic inflammation.
cPLA2alpha may play a key role in renal repair after injury through a PGE2-independent mechanism
This study indicates the potential role of cPLA2alpha in breast cancer metastasis and indicates that this molecule is a promising therapeutic target for breast cancer.
these studies suggests that cPLA2alpha expressed by neutrophils, but not epithelial cells, plays a significant role in infection-induced neutrophil transepithelial migration by mediating LTB4 (show PTGR1 Proteins) synthesis during migration, which serves to amplify the magnitude of neutrophil recruitment in response to epithelial infection
cPLA2alpha activates PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) and inhibits Smad2 (show SMAD2 Proteins)/3 during epithelial-mesenchymal transition of hepatocellular carcinoma cells.
Phospholipase activity is linked to energy metabolism, revealing cPLA2 as a central regulator of both lipidomics and energy flux.
present study indicates that among all cytosolic phospholipases A2, specific phospholipase A2 group IVA are the main enzymes involved in cigarette smoke induced anomalies in type I and type II lung epithelial cells
genetic association study in Quebec City population: Data suggest total plasma n-6 fatty acid phospholipid levels and C-reactive protein (show CRP Proteins) are modulated by SNPs in PLA2G4A and PLA2G6 (show PLA2G6 Proteins) alone or in combination with fish oil dietary supplementation.
result suggests that cPLAPgamma may act as a G protein, activating cPLA(2)alpha prior to reaching full intracellular Ca(2 (show CA2 Proteins) ) concentrations
Ovulation is associated with an LH/hCG (show CGA Proteins)-dependent induction of PLA2G4A in GC via the adenylyl cyclase/cAMP pathway.
Activation of cytosolic phospholipase A2 and fatty acid transacylase is essential but not sufficient for thrombin (show F2 Proteins)-induced smooth muscle cell proliferation.
The results indicate that PLA2 (show YWHAZ Proteins) activity in equine endometrium changes with the stage of the oestrous cycle and thus may be influenced by systemic hormone concentrations.
During pregnancy, PLA2 (show YWHAZ Proteins) expression may be sufficient to initiate the cascade for prostaglandin f2alpha secretion and does not play a direct role in maternal recognition of pregnancy.
the cytosolic phospholipase cPLA2alpha is activated through Gbetagamma downstream of Smo to release arachidonic acid. Arachidonic acid binds Smo and synergizes with CRD-binding agonists, promoting Smo ciliary trafficking and high-level signaling.
In microglia, cPLA2 up-regulates the expression of CD40 (show CD40 Proteins) protein.
LacCer alone simultaneously stimulates two processes to activate cPLA2 alpha: a phosphorylation signal and attachment of the enzyme to substrate membranes.
this study shows that cPLA2alpha contributes to immune surveillance and host defense in the lung to prevent infection by the commensal fungus Candida albicans and to dampen inflammation
Reduction of cPLA2alpha in the brainstem and spinal cord significantly attenuated the development of an animal model of amyotrophic lateral sclerosis.
Data suggest that the ability of pyrrophenone to block endoplasmic reticulum (ER) calcium release is an off-target effect since it occurs in fibroblasts lacking cytosolic phospholipase A2alpha (cPLA2alpha).
these results show that preadipocyte cPLA2alpha activation is a hitherto unrecognized factor for adipogenesis in vitro and in vivo.
The data emphasize the importance of the PLCeta2 EF-hand domain and articulation of PLCeta2 with LIMK-1 (show LIMK1 Proteins) in regulating neuritogenesis.
show that accumulation of Abeta (show APP Proteins) induced elevation of APP (show APP Proteins) protein expression mediated by cPLA2 alpha, PGE2 release, and CREB (show CREB1 Proteins) activation via protein kinase A pathway
Data show that glycation end products (AGE) increase PIP2 production, arachidonic acid release and reactive oxygen species via cytosolic phospholipase A2 activation, and inhibit Na+ K+ ATPase (show ATP1A1 Proteins) surface expression via PIP5Kgamma (show PIP5K1C Proteins).
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
, calcium-dependent phospholipid-binding protein
, cytosolic phospholipase A2
, phosphatidylcholine 2-acylhydrolase
, phospholipase A2 group IVA
, phospholipase A2 cytosolic
, Phospholipase A2 group IVA
, phospholipase A2, group IB (pancreas)
, Cytosolic phospholipase A2 (CPLA2)
, Type IV PLA2
, cytosolic PLA2
, phospholipase A2, group 4
, phospholipase A2, group IVA (cytosolic, calcium-dependent)