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We found no significant influence of the PLA2G6 and PLA2G4C polymorphisms on mean age at first hospital admission (P > 0.05) and that the investigated polymorphisms significantly influenced the clinical psychopathology only in male patients. The PLA2G4C polymorphism accounted for approximately 12% of negative symptom severity.
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Five single-nucleotide polymorphisms (SNPs) (rs9226, rs1045376, rs251684, rs2307279, and rs156631) in PLA2G4C and four SNPs (rs6533451, rs2285714, rs2285713, and rs11728699) in PLA2G12A were selected and genotyped. Our results showed a significant association between ASD and the rs251684 variant of PLA2G4C. The rs251684 polymorphism of PLA2G4C may be associated with Autism Spectrum Disorder risk.
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The A allele in PLA2G4C single nucleotide polymorphism (rs1549637) is associated with a worse prognosis in patients with colorectal cancer, especially in stage II.
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Results demonstrated no significant impact of PLA2G6 and PLA2G4C gene polymorphisms on attenuated niacin skin flushing in schizophrenia patients.
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site-specific cytosine methylation of the CpT of PLA2G4C may play a role in the pathogenesis of schizophrenia.
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These findings suggest that IVC-PLA(2) is involved in regulations of macrophage differentiation and macrophage polarization.
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these results suggest that cPLA(2)gamma plays an important role in cancer cell chemotaxis.
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Findings suggest that variation in PLA2G4C may influence preterm birth risk by increasing levels of prostaglandins, which are known to regulate labor.
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cPLA(2) has a role in the induction of cell autonomous cellular immunity to Chlamydia
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locus showed a weak association with schizophrenia in a Chinese population
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Novel PLA2G4C polymorphism as a molecular diagnostic A minisatellite polymorphism in the untranslated region of exon 1, with allelic variants that have one, two or three 27-bp repeats
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enzymatic properties
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TNF-alpha & IFN-gamma induce gene expression of a novel cytosolic PLA(2) IVC in human airway epithelial cells. The possibility that it is involved in cytokine-mediated inflammation in the respiratory tract is inferred.
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Down-regulation of Phospholipase A2 is associated with colon tumorigenesis
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identification of its remarkable substrate selectivity that results in the highly selective generation of 2-arachidonoyl lysophosphatidylcholine
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results indicate that complete C-terminal processing is important for the functional expression of cPLA2, although not for its membrane localization
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Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells
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iPLA2gamma has roles in the lipid plasticity of myocardium, in generating signaling metabolites, and in modulating energy storage and utilization in myocardium in different metabolic contexts
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Single nucleotide polymorphism is asociated with schizzophrenia in a Chinese population.
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endometrial cell PGE2 biosynthesis was associated with PLA2G4C expression and activity
