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Here, the authors report that the zebrafish/human phosphatidylinositol transfer protein (show PITPNA Proteins) Sec14l3 (show SEC14L3 Proteins)/SEC14L2 (show SEC14L2 Proteins) act as GTPase (show RACGAP1 Proteins) proteins to transduce Wnt (show WNT2 Proteins) signals from Frizzled to phospholipase C (PLC (show PLC Proteins)).
Serial deletion analysis identified the core PLC-delta4 promoter region as being between -402 and -67, in which an E-box and an AP-1 (show FOSB Proteins) binding site played important roles in the promoter activity.
We identify PLCdelta4 as a PLC (show HSPG2 Proteins) isoform important in the regulation of TRPM8 (show TRPM8 Proteins) both at the cellular level and in vivo
These findings highlight a novel pathway by which nuclear PLCs affect insulin (show INS Proteins) secretion and identify PPARgamma (show PPARG Proteins) as a novel molecular target of nuclear PLCs.
PLCd4 has a role in the zona pellucida-induced acrosome reaction in mice
It is concluded that PLC delta4 regulates the liver regeneration in cooperation with nuclear PKC alpha (show PKCa Proteins) and epsilon
PLCd4 is required for the acrosome reaction in fertilization.
This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer.
phospholipase C, eta 1
, phospholipase C-like 3
, phospholipase C, delta 4
, phospholipase C delta 4
, DrPLC-delta 4A
, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4
, phosphoinositide phospholipase C-delta-4
, phospholipase C-delta-4
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4-like
, PLC delta4
, phosphoinositide phospholipase C delta-4
, phospholipase C-delta-2
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 4