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Here, the authors report that the zebrafish/human phosphatidylinositol transfer protein Sec14l3/SEC14L2 act as GTPase proteins to transduce Wnt signals from Frizzled to phospholipase C (PLC).
PLCdelta(1) and PLCdelta(4) are probably differentially regulated in distinct cellular compartments by PI(4,5)P(2) and the PH domain of PLCdelta(4) does not act as a localization signal
Serial deletion analysis identified the core PLC-delta4 promoter region as being between -402 and -67, in which an E-box and an AP-1 binding site played important roles in the promoter activity.
We identify PLCdelta4 as a PLC isoform important in the regulation of TRPM8 both at the cellular level and in vivo
These findings highlight a novel pathway by which nuclear PLCs affect insulin secretion and identify PPARgamma as a novel molecular target of nuclear PLCs.
PLCd4 has a role in the zona pellucida-induced acrosome reaction in mice
It is concluded that PLC delta4 regulates the liver regeneration in cooperation with nuclear PKC alpha and epsilon
PLCd4 is required for the acrosome reaction in fertilization.
This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer.
phospholipase C, eta 1
, phospholipase C-like 3
, phospholipase C, delta 4
, phospholipase C delta 4
, DrPLC-delta 4A
, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4
, phosphoinositide phospholipase C-delta-4
, phospholipase C-delta-4
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4-like
, PLC delta4
, phosphoinositide phospholipase C delta-4
, phospholipase C-delta-2
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 4