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anti-Human PKC delta Antibodies:
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Human Polyclonal PKC delta Primary Antibody for WB - ABIN2802039
Aris, Basta, Holmes, Ballas, Moomaw, Rankl, Blobel, Loomis, Burns: Molecular and biochemical characterization of a recombinant human PKC-delta family member. in Biochimica et biophysica acta 1993
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Human PKC delta Primary Antibody for IHC - ABIN966837
Sakamoto, Aschenbach, Hirshman, Goodyear: Akt signaling in skeletal muscle: regulation by exercise and passive stretch. in American journal of physiology. Endocrinology and metabolism 2003
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Human Polyclonal PKC delta Primary Antibody for IHC - ABIN966838
Zhang, Keane, Zhu, Sharma, Rozengurt, Strieter, Dubinett, Huang: Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis. in The Journal of biological chemistry 2004
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Human Monoclonal PKC delta Primary Antibody for IF, ELISA - ABIN562385
Chen, Nguyen, Shively: Role of calpain-9 and PKC-delta in the apoptotic mechanism of lumen formation in CEACAM1 transfected breast epithelial cells. in Experimental cell research 2010
Human Polyclonal PKC delta Primary Antibody for IHC, WB - ABIN362384
Van Kolen, Slegers: Atypical PKCzeta is involved in RhoA-dependent mitogenic signaling by the P2Y(12) receptor in C6 cells. in The FEBS journal 2006
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Human Polyclonal PKC delta Primary Antibody for WB - ABIN3043360
Gan, Wang, Zhao, Wu, Yang, Peng: 5-(Bis(3-(2-hydroxyethyl)-1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHIMHA): showing a strategy of designing drug to block lung metastasis of tumors. in Drug design, development and therapy 2016
Tumor suppressor activity of Protein kinase C-delta.[review]
Protein kinase C acts as a tumor suppressor.Cancer-associated mutations in protein kinase C are generally loss-of-function mutations.[review]
Data suggest a targeted therapy and early medical intervention for protein kinase C delta (PKCdelta) could be a useful option for breast cancer cases complicated with type 2 diabetes mellitus (T2DM) or hyperglycemia.
NSC606985 produced a dose-dependent subcellular activation of PKCdelta. The dose-dependent dual action of NSC is mediated at least in part through the differential subcellular activation of castration-resistant prostate cancer (CRPC) LAPC4 cells.
PKC-delta expression is associated with KIT expression and the prognosis of patients with adenoid cystic carcinomas (AdCCs), suggesting that PKC-delta may be a potential therapeutic target for AdCCs.
Taken together, our findings suggest that TM-PKCdelta interaction may contribute to cardiovascular disorders by affecting monocye differentiation, which may develop future therapeutic applications.
PKC-delta played as a protective role in squamous cell carcinomas partly by down-regulating p63 (show RPE65 Antibodies), leading to the suppression of squamous cell carcinomas cell proliferation
Activated PKCdelta interacts with the polymerase subunit PB2 and phospho-regulates NP oligomerization and RNP (show RNPC3 Antibodies) assembly during Influenza A virus infection.
NRF2 (show GABPA Antibodies) Ser40 phosphorylation was inhibited in Crif1 (show GADD45GIP1 Antibodies)-deficient bone marrow multipotent mesenchymal stromal cells even in the presence of three kinds of PKC (show PRRT2 Antibodies) agonists, suggesting that CRIF1 (show GADD45GIP1 Antibodies) might co-activate PKC-delta to phosphorylate NRF2 (show GABPA Antibodies) Ser40.
PKCdelta has an overall negative influence on platelet function in response to collagen, while, following PAR (show JTB Antibodies) stimulation, PKCdelta has a positive effect on platelet function. PKCdelta has different roles in platelet activation, aggregation and thrombus formation. Review.
These results suggest that CD40-activated CD40L reverse signalling has striking and opposite effects on the growth and elaboration of dendrites among major classes of brain neurons by PKC-dependent mechanisms.
Our key findings provide novel insights into the mechanism of action of heterotrimeric complex (PKCdelta-TIRAP (show TIRAP Antibodies)-p38 (show CRK Antibodies)) in proinflammatory cytokine expression, which controls the development of the inflammatory trigger in stimulated macrophages.
sustained PKCdelta activation drives sustained microglial inflammatory responses and concomitant dopaminergic neurotoxicity consequently leading to neurobehavioral deficits
spinal PKCdelta has a role in the development of chronic pain in SCD (show SCD Antibodies), which may become a potential target for pharmacological interventions
K8/K18 (show KRT18 Antibodies)-dependent PKCdelta- and ASMase (show SMPD1 Antibodies)-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 (show KRT18 Antibodies) loss.
MALAT1 recruits splice factor serine-arginine-rich splice factor 2 (SRSF2 (show SRSF2 Antibodies)) to promote alternative splicing of PKCdeltaII.
SphK1 (show SPHK1 Antibodies) dependent PKC-delta activation plays an important role in promoting NF-kappaB (show NFKB1 Antibodies) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta activation might be a potential therapeutic strategy for this disease.
PKCdelta activity exerts a dual role through the autophagy mechanism, decreasing proliferative capacity of mammary tumor cells but also regulating tumor stem cell self-renewal.
alpha(1)-AR activation is anti-apoptotic and protective during cardiac ischemia due to glucose deprivation and not hypoxia by enhancing glucose uptake into the heart via PKCdelta-mediated GLUT (show SLC1A3 Antibodies) translocation that may be specific to the alpha(1A)-AR subtype.
Study shows that PRKCD influences corticotroph cell viability, POMC (show POMC Antibodies) and ACTH (show POMC Antibodies) expression suggesting that PRKCD plays an important role in restraining corticotroph cell proliferation and function.
Report PRKCD-dependent regulation of bovine embryonic development, gene expression and post-hatching events.
investigation of signaling mechanism used by fibroblast growth factor-2 (FGF2 (show FGF2 Antibodies)) to regulate interferon-tau (IFNT) production in trophoblasts: several lines of evidence suggest that FGF2 (show FGF2 Antibodies) regulates IFNT production in trophoblasts by acting through PRKCD
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS (show NOS3 Antibodies) post-translational modification
stimulation of bovine theca cells with lysophosphatidic acid leads to redistribution of protein kinase C delta from the cytosol to the perinuclear area and in the presence of LH, complete nuclear translocation of protein kinase C delta is induced
Protein kinase (show CDK7 Antibodies) Cdelta-dependent phosphorylation of syndecan-4 (show SDC4 Antibodies) regulates cell migration.
Activation of PKC induces the translocation of Nrf2 (show NFE2L2 Antibodies) and the enhancement of endogenous antioxidant defenses in ischemic preconditioned rabbit heart.
PKC-delta (show PRKCG Antibodies) mediates the apoptotic processes through ROS (show ROS1 Antibodies)-dependent caspase-3 (show CASP3 Antibodies) activation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed.
protein kinase C delta VIII
, protein kinase C delta type
, tyrosine-protein kinase PRKCD
, protein kinase C delta variant IX
, protein kinase C, delta IV
, protein kinase C, delta V
, protein kinase C[d]
, protein kinase-delta2
, protein kinase C, delta
, protein kinase C delta type-like
, protein kinase C delta