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Human Arrestin 3 Protein expressed in Wheat germ - ABIN1345726
Quack, Woznowski, Potthoff, Palmer, Königshausen, Sivritas, Schiffer, Stegbauer, Vonend, Rump, Sellin: PKC alpha mediates beta-arrestin2-dependent nephrin endocytosis in hyperglycemia. in The Journal of biological chemistry 2011
These results show that b-arrestin1 (show SAG Proteins) and b-arrestin2 exert differential actions on PAC1R (show ADCYAP1R1 Proteins) internalization and PAC1R (show ADCYAP1R1 Proteins)-dependent ERK1/2 activation, and suggest that the two b-arrestin (show SAG Proteins) isoforms may be involved in fine and precise tuning of the PAC1R (show ADCYAP1R1 Proteins) signaling pathways.
overexpression of beta-arrestin2 can inhibit the growth of renal cell carcinoma (show MOK Proteins) (RCC (show XRCC1 Proteins)) cells in vitro, and beta-arrestin2 acts as a tumor suppressor gene in RCC (show XRCC1 Proteins); the main mechanism may directly suppress the phosphorylation of IkBa (show NFKBIA Proteins) and indirectly suppress NFkB
Study investigated the association between five ARRB2 single nucleotide polymorphisms (SNPs): rs1045280, rs2036657, rs4790694, rs3786047 and rs452246, and response to antidepressant treatment in a sample of 569 patients with a major depressive episode treated for 6months: GG/GT patients for rs4522461 and AA/AC patients for rs4790694 had a lower response.
Itch/beta-arrestin2 complex binds SuFu and induces its Lys63-link (show SUFUH Proteins)ed polyubiquitylation without affecting its stability.
These data highlight a novel arrestin (show SAG Proteins)-mediated modulation of CREB (show CREB1 Proteins) signalling, suggesting a reciprocal relationship between arrestin2 and arrestin3, wherein recruitment of arrestin3 restricts the ability of beta2AR (show ADRB2 Proteins) to activate prolonged CREB (show CREB1 Proteins) phosphorylation by precluding recruitment of an arrestin2/Src (show SRC Proteins)/p38 (show CRK Proteins) complex.
A novel regulatory role of GRK2 was proposed for the ubiquitination of beta-arrestin in the context of the PKC-mediated heterologous regulation of GPCRs.
USP33 (show USP33 Proteins) may indirectly regulate the degradation and recycling of CXCR4 (show CXCR4 Proteins) through deubiquitinating beta-arrestin2, promoting colorectal tumor cell metastasis.
Antihistamines displayed similar kinetic signatures on antagonizing histamine-induced beta-arrestin2 recruitment as compared to displacing radioligand binding from the H1R (show HRH1 Proteins).
the internalization motif for the human neuropeptide Y4 receptor, which regulates arrestin-3 recruitment and receptor endocytosis, was identified.
Collectively, these data show that beta-arrestin2 phosphorylation at Thr(383) underlies beta-arrestin-dependent Erk1/2 activation by G protein-coupled receptors.
The fraction of arrestin2 molecules found in clusters larger than 100nm correlates with the magnitude of ligand-induced CCR5 internalization.
K2A mutations in arrestin-1 (show SAG Proteins), -2, and -3 significantly reduced their binding to active phosphorhodopsin.
Results reveal that multiple intramolecular interactions coordinately regulate arrestin2 interaction with clathrin, highlighting this interaction as a critical step in regulating receptor trafficking.
Spinal Arrb2 may serve as an intracellular gate for acute to chronic pain transition via desensitization of NMDAR (show GRIN1 Proteins).
Knockout of mice beta-arrestin2, but not beta-arrestin1 (show ARRB1 Proteins), results in deficits in plasticity mediated by mGlu1 (show GRM1 Proteins) receptors in CA3 (show CA3 Proteins) pyramidal neurons and by mGlu5 (show GRM5 Proteins) receptors in CA1 (show CA1 Proteins) pyramidal neurons.
beta-arrestin 2 can protect liver tissue from LPS (show TLR4 Proteins)-induced injury via inhibition of TLR4 (show TLR4 Proteins)/NF-kappaB (show NFKB1 Proteins) signaling pathway-mediated inflammation.
Non-visual arrestins regulate the focal adhesion formation via small GTPases RhoA and Rac1 independently of G-protein-coupled receptors.
Arrb2 induces cardiomyocyte death by interacting with the p85 subunit of PI3K, and negatively regulating the formation of p85-PI3K/CaV3 survival complex, thus blocking activation of PI3K-Akt-GSK3beta cell survival signalling pathway in cardiac ischemia-reperfusion.
these results suggest that beta-arrestin2 down-regulation increases hepatocellular carcinoma cell migration and invasion ability
beta-Arrestin2 increases the Itch-mediated ubiquitylation of SuFu (show SUFUH Proteins)
Our data reveal beta-arrestin 1 (show ARRB1 Proteins), beta-arrestin 2, and AT1R (show AGTRAP Proteins) as key regulatory molecules in the Frank-Starling mechanism, which involves length-dependent enhancement of cardiac myofilament Ca(2 (show CA2 Proteins)+) sensitivity.
Arrestin (show SAG Proteins) beta2 deficiency-mediated intestinal progenitor/stem cell radioprotection relied on protracted NF-kappaB (show NFKB1 Proteins) activation and subsequent suppression of PUMA (show BBC3 Proteins) induction.
GIP stimulation induces a switch in GIPR recycling from a rapid endosomal to a slow trans-Golgi network (TGN) pathway. GPCR kinases and b-arrestin2 are required for this switch in recycling.
Arrb2 physically interacts with the beta subunit (show POLG Proteins) of trimeric G-proteins and Dishevelled (show DVL2 Proteins), the interaction between arrb2 and Dishevelled (show DVL2 Proteins) is promoted by the beta/gamma subunits of trimeric G-proteins.
results suggest that a functional interaction between beta-arrestin 2 and Smoothened may be critical to regulate hedgehog (show SHH Proteins) signaling in zebrafish development
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
arrestin beta 2
, arrestin, beta 2
, arrestin 2
, beta-Arrestin 2
, arrestin beta-2
, arrestin 3
, beta arr2
, beta-arrestin 2