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Human Arrestin 3 Protein expressed in Wheat germ - ABIN1345726
Quack, Woznowski, Potthoff, Palmer, Königshausen, Sivritas, Schiffer, Stegbauer, Vonend, Rump, Sellin: PKC alpha mediates beta-arrestin2-dependent nephrin endocytosis in hyperglycemia. in The Journal of biological chemistry 2011
A novel regulatory role of GRK2 was proposed for the ubiquitination of beta-arrestin in the context of the PKC-mediated heterologous regulation of GPCRs.
USP33 (show USP33 Proteins) may indirectly regulate the degradation and recycling of CXCR4 (show CXCR4 Proteins) through deubiquitinating beta-arrestin2, promoting colorectal tumor cell metastasis.
Antihistamines displayed similar kinetic signatures on antagonizing histamine-induced beta-arrestin2 recruitment as compared to displacing radioligand binding from the H1R (show HRH1 Proteins).
the internalization motif for the human neuropeptide Y4 receptor, which regulates arrestin-3 recruitment and receptor endocytosis, was identified.
Collectively, these data show that beta-arrestin2 phosphorylation at Thr(383) underlies beta-arrestin-dependent Erk1/2 activation by G protein-coupled receptors.
Data indicate that a constitutively monomeric CXCL12 (show CXCL12 Proteins) variant reproduced the G protein-dependent and beta-arrestin-dependent responses that are associated with normal CXCR4 (show CXCR4 Proteins) signaling and lead to cell migration.
This work demonstrates that the expression of FSHR (show FSHR Proteins) and LHCGR (show LHCGR Proteins) can be induced in hGL5 cells but that the FSHR (show FSHR Proteins)-dependent cAMP/PKA pathway is constitutively silenced, possibly to protect cells from FSHR (show FSHR Proteins)-cAMP-PKA-induced apoptosis.
Lowering the level of cellular FLNA caused an elevation in RalA activity and resulted in selective interference with the normal intracellular trafficking and signaling of D3R through beta-arrestins.
This study reveals contrasting abilities of IGF-1R (show IGF1R Proteins) to interact with each b-arrestin (show SAG Proteins) isoform, depending on the presence of the ligand and demonstrates the antagonism between the two b-arrestin (show SAG Proteins) isoforms in controlling IGF-1R (show IGF1R Proteins) expression and function, which could be developed into a practical anti-IGF-1R (show IGF1R Proteins) strategy for cancer therapy.
Results demonstrate that GPR3 (show GPR3 Proteins) signals at the plasma membrane and can be silenced by GRK2 (show ADRBK1 Proteins)/beta-arrestin overexpression. These results also strongly implicate the serine and/or threonine residues in the third intracellular loop in the regulation of GPR3 (show GPR3 Proteins) activity.
The fraction of arrestin2 molecules found in clusters larger than 100nm correlates with the magnitude of ligand-induced CCR5 internalization.
K2A mutations in arrestin-1 (show SAG Proteins), -2, and -3 significantly reduced their binding to active phosphorhodopsin.
Results reveal that multiple intramolecular interactions coordinately regulate arrestin2 interaction with clathrin, highlighting this interaction as a critical step in regulating receptor trafficking.
Our data reveal beta-arrestin 1 (show ARRB1 Proteins), beta-arrestin 2, and AT1R (show AGTRAP Proteins) as key regulatory molecules in the Frank-Starling mechanism, which involves length-dependent enhancement of cardiac myofilament Ca(2 (show CA2 Proteins)+) sensitivity.
Arrestin (show SAG Proteins) beta2 deficiency-mediated intestinal progenitor/stem cell radioprotection relied on protracted NF-kappaB (show NFKB1 Proteins) activation and subsequent suppression of PUMA (show BBC3 Proteins) induction.
GIP stimulation induces a switch in GIPR recycling from a rapid endosomal to a slow trans-Golgi network (TGN) pathway. GPCR kinases and b-arrestin2 are required for this switch in recycling.
beta-arrestin2-biased negative modulators of mGlu5 (show GRM5 Proteins) offer significant advantages over first-generation inhibitors for the treatment of fragile X (show FMR1 Proteins) and related disorders.
selective inactivation of the GPCR (show GPBAR1 Proteins)-associated protein beta-arrestin 2 in hepatocytes of adult mice results in greatly increased hepatic GCGR (show GCGR Proteins) signaling, leading to striking deficits in glucose homeostasis
AT1R (show AGTRAP Proteins)-beta-arrestin-2 pathway signaling plays an important role in renal fibrosis.
These data suggest that one allele of arrestin-2 (show ARRB1 Proteins) is unable to support normal locomotor behavior due to signaling and/or developmental defects.
Beta-arrestin-2 with beta-arrestin-1 shared common mechanisms to suppress podocyte autophagy by negative regulation of ATG12-ATG5 conjugation.
[beta]-arrestin2 regulates intestinal mucosal inflammation under both homeostatic and colitic conditions. Its mode of action involves negative regulation of T-cell activation and its requirement for induction of regulatory T cells.
Results suggest that the antipruritic effects of kappa opioid receptor (show OPRK1 Proteins) agonists may not require betaarrestin2
Arrb2 physically interacts with the beta subunit (show POLG Proteins) of trimeric G-proteins and Dishevelled (show DVL2 Proteins), the interaction between arrb2 and Dishevelled (show DVL2 Proteins) is promoted by the beta/gamma subunits of trimeric G-proteins.
results suggest that a functional interaction between beta-arrestin 2 and Smoothened may be critical to regulate hedgehog (show SHH Proteins) signaling in zebrafish development
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
arrestin beta 2
, arrestin, beta 2
, arrestin 2
, beta-Arrestin 2
, arrestin beta-2
, arrestin 3
, beta arr2
, beta-arrestin 2