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CoCoA and CCAR1 appear to relay the GATA1 signal to MED1, and multiple modes of the GATA1-MED1 axis may help to fine-tune GATA1 function during GATA1-mediated homeostasis events.
Results report a novel human protein, calphoglin, which activates inorganic pyrophosphatase (IPP) and enhances phosphoglucomutase activity through the activated IPP.
CoCoA uses different combinations of functional domains in its synergistic coactivator function with beta-catenin or GRIP1
The N terminus of CoCoA contains another activation domain , which is necessary and sufficient for synergistic activation of LEF1-mediated transcription by CoCoA and beta-catenin.
May function as a coactivator for aryl hydrocarbon and nuclear receptors (By similarity).
calcium binding and coiled-coil domain 1
, coiled-coil transcriptional coactivator
, calcium-binding and coiled-coil domain-containing protein 1-like
, calcium-binding and coiled-coil domain-containing protein 1
, GRIP1-interacting protein
, coiled-coil coactivator protein
, granule cell antiserum positive 11
, coiled-coil leucine zipper coactivator 1
, inorganic pyrophosphatase activator
, sarcoma antigen NY-SAR-3