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tissue-specific steroid concentrations may have a strong impact on CYP7B1-dependent catalysis and thus on the levels of different CYP7B1-related steroids that can influence estrogen receptor beta (show ESR2 Proteins) signaling
SPG11 and CYP7B1 were the most common cause of autosomal recessive hereditary spastic paraplegia in Greece.
miR17 induces epithelial-mesenchymal transition consistent with the cancer stem cell phenotype by regulating CYP7B1 expression in colon cancer.
Data indicate two novel homozygous mutations (one frameshift and one missense mutation) detected in CYP7B1 (SPG5A), while no disease-causing mutation was identified for PNPLA6 (SPG39 (show PNPLA6 Proteins)) and C19orf12 (SPG43).
Data indicated that the two GWAS-defined variants in the CYP7B1 region do not strongly influence HIV-1 infection susceptibility.
Using an agnostic omics approach to focus on the association of CWP with body mass index, we have confirmed a steroid hormone association and identified a genetic variant upstream of the CYP (show PPIG Proteins) genes, which likely controls this response.
Spastic paraplegia type 5 has a higher frequency in Taiwanese than in other ethnic groups, associated with a CYP7B1 founder mutation and its phenotype is characterized by pronounced dorsal column sensory loss, with cerebellar ataxia in some patients.
The patient was homozygous for a mutation (c.1249C>T) in CYP7B1 that alters a highly conserved residue in oxysterol 7 alpha-hydroxylase previously reported in a family with hereditary spastic paraplegia type 5
enduring sensory ataxia can be a pivotal sign in SPG5, and expands the phenotypic spectrum associated with mutations in CYP7B1
21-hydroxy-pregnenolone was identified as a new substrate, and overall low activity toward pregnanes could be related to the increased potency of 7-hydroxy derivatives produced by CYP7B1.
investigation of CYP7B1-substrate binding modes
Findings indicate that CYP7B1 and HSD3B7 (show HSD3B7 Proteins), as well as CH25H (show CH25H Proteins), have essential roles in controlling oxysterol production in lymphoid tissues.
Because CYP7B1 represents the major pathway for inactivating 3betaAdiol in the prostate, we suggest that ERbeta (show ESR2 Proteins), 3betaAdiol, and CYP7B1 are the components of a pathway that regulates growth of the rodent ventral prostate.
Identification of Cyp7b1 as a novel RORalpha (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3).
Data show that ten genes (Fsp27 (show CIDEC Proteins), Aqp4 (show AQP4 Proteins), Cd36 (show CD36 Proteins), Ly6d (show LY6D Proteins), Scd1 (show SCD Proteins), Hsd3b5, Syt1 (show SYT1 Proteins), Cyp7b1, and Tff3 (show TFF3 Proteins)) showed significant associations among their expressions and the degree of hepatic steatosis.
CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis.
, cytochrome P450, family 7, subfamily B, polypeptide 1
, 25-hydroxycholesterol 7-alpha-hydroxylase
, cytochrome P450 7B1
, cytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1
, oxysterol 7-alpha-hydroxylase
, cytochrome P450, 7b1
, hippocampal transcript 1 protein
, cytochrome P450, subfamily 7B, polypeptide 1