Browse our DAB2 Proteins (DAB2)

Human Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) interaction partners

1. DAB2 might be involved in excessive aldosterone biosynthesis and correlate with specific clinical characteristics of aldosterone-producing adenoma patients.

2. the results indicated that substrate stiffness could regulate EMT (show ITK Proteins) of cervical cancer cell lines HeLa and SiHa at least partially through miR (show MLXIP Proteins)-106b and its downstream target DAB2.

3. DAB2 can suppress the ERK (show EPHB2 Proteins) signaling, but correlate to have TGF-beta (show TGFB1 Proteins)-induced epithelial-to-mesenchymal transition (EMT (show ITK Proteins)) in esophageal squamous cell carcinomas (ESCCs).

4. The various novel mechanisms are described by which Dab2 mediates an array of signaling events with vast physiological consequences.

5. In conclusion, DAB2 and Intelectin-1 (show ITLN1 Proteins) are newly identified positive markers of mesothelioma and have potential to be included in future immunohistochemical marker panels for differentiation of epithelioid mesothelioma from pulmonary adenocarcinoma

6. cathepsin B (CTSB (show CTSB Proteins)) inhibition or expression of a CTSB (show CTSB Proteins)-resistant Dab2 mutant maintains Dab2 expression and shifts long-term TGF-beta (show TGFB1 Proteins)-treated cells from autophagy to apoptosis

7. abundances of megalin (show LRP2 Proteins) and Dab2 (p = 0.046) were reduced in infected placentas from women with LBW deliveries

8. Data show that miR106b was frequently up-regulated in human cervical carcinoma tumors and cell lines and inversely correlated with DAB2 expression. Its regulation in under TGF-beta1 (show TGFB1 Proteins) which contributes to cell migration by targeting DAB2 in cervical carcinoma.

9. these findings reveal that DAB2 is critical for controlling inflammatory signaling during phenotypic polarization of macrophages

10. inhibition of WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling by DAB2 is essential for establishing the correct number of cardiomyocytes in the developing heart.

Mouse (Murine) Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) interaction partners

1. The various novel mechanisms are described by which Dab2 mediates an array of signaling events with vast physiological consequences.

2. The combination of Arh (show LDLRAP1 Proteins) and Dab2 is responsible for the majority of adaptor function in LDLR (show LDLR Proteins) endocytosis and LDLR (show LDLR Proteins)-mediated cholesterol homeostasis.

3. cathepsin B (CTSB (show CTSB Proteins)) inhibition or expression of a CTSB (show CTSB Proteins)-resistant Dab2 mutant maintains Dab2 expression and shifts long-term TGF-beta (show TGFB1 Proteins)-treated cells from autophagy to apoptosis

4. Results identified a novel activation marker, DAB2, which expression is significantly different between microglia activation stages M2a and either M1 or M2b.

5. these findings reveal that DAB2 is critical for controlling inflammatory signaling during phenotypic polarization of macrophages

6. Dab2 expression is induced by hormones

7. Results suggest that endogenous Dab2 exacerbates central nervous system inflammation, potentially acting to up-regulate reactive oxygen species expression in macrophages and microglia, and that it is of potential pathogenic relevance in multiple sclerosis

8. Disabled-2 is required for efficient hemostasis and platelet activation by thrombin (show F2 Proteins) in mice.

9. Akt1 (show AKT1 Proteins) and Akt2 (show AKT2 Proteins) are involved in albumin (show ALB Proteins) endocytosis, and phosphorylation of Dab2 by Akt (show AKT1 Proteins) induces albumin (show ALB Proteins) endocytosis in proximal tubule epithelial cells.

10. Study of dab2 mutant allele in embryos and embryoid bodies confirms a role for Dab2 in extraembryonic endoderm development and epithelial organization. Also, Dab2 has a physiological role in the endocytosis of lipoproteins and cholesterol metabolism.

Cow (Bovine) Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2) interaction partners

1. Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2, and NR3C1 (show NR3C1 Proteins). TNF (show TNF Proteins) and IL6 (show IL6 Proteins) levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.